Brittney Newby, MD, PhD
Locations: Main Building
About Brittney Newby, MD, PhD
Titles
Fellow
Awards and Honors
2022, Childhood Arthritis and Rheumatology Research Alliance (CARRA) Arthritis Foundation Pediatric Resident Program
2021, Academic Pediatric Societies New Century Scholar
2020, American College of Rheumatology (ACR) Convergence - Pediatric Rheumatology Residents Program
2019, AMSPDC Frontiers in Science Resident Scholar
2018, Gold Humanism Honor Society Inductee – UF Chapman Chapter
2006-2008, MEAC All-Academic Team, Mid-Eastern Athletic Conference
2007, Student Athlete of the Year, Florida A&M University
Leadership and Memberships
2022-present, Childhood Arthritis and Rheumatology Research Alliance (CARRA)
2020-present, Providers of Pride at CHOP, Founding Member
2020- present, American College of Rheumatology (ACR)
2019-present, University of Pennsylvania Alliance of Minority Physicians
2019-present, CHOP Multicultural Physician’s Alliance
2018-present, Gold Humanism Honor Society
2018-present, American Academy of Pediatrics
Research Interests
Immunology Immunopathogenesis of autoimmune and autoinflammatory diseases Interplay between environment and genetics in tissue specific immune responses
Education & training
Graduate Degree
PhD in Biomedical Sciences with a Concentration in Immunology - University of Florida College of Medicine, Gainesville, FL
Medical Degree
MD - University of Florida College of Medicine, Gainesville, FL
Residency
Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA (Chief Resident)
Fellowship
Pediatric Rheumatology - Children’s Hospital of Philadelphia, Philadelphia, PA
Publications
Publications
2021
Armitage LH, Stimpson SE, Santostefano KE, Sui L, Ogundare S, Newby BN, Casto-Gutierrez R, Huber ML, Taylor JP, Sharma P, Radichev IA, Perry DJ, Fredette NC, Savinove AY, Wallet MA, Terade N, Brusko TM, Russ HA, Chen J, Egli E, Mathews CE. Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes. Front. Endocrinol., 09 November 2021. doi.org/10.3389/fendo.2021.737276
Chen J, Lui C, Chernatynskaya A, Newby BN, Brusko TM, XuY, Morgan N, Santarlas CP, Reeves WH, Tse HM, Leiding JW, Mathews CE. NADPH Oxidase 2 Derived Reactive Oxygen Species Promote CD8+ T cell Effector Function. bioRxiv 2021.02.24.432756; doi: https://doi.org/10.1101/2021.02.24.432756
2020
Stimpson SE, Chen J, Newby BN, Khattri R, Chapman H, Angelini T, Merritt, M, Serreze D, Mathews CE (2020). Human CD8+ T-cells Require Glycolysis to Elicit Effector Function. 10.1101/2020.02.05.935627.
Dean JW, Peters LD, Fuhrman CA, Seay HR, Posgai AL, Stimpson SE, Brusko MA, Perry DJ, Yeh WI, Newby BN, Haller MJ, Muir AB, Atkinson MA, Mathews CE, Brusko TM. Innate inflammation drives NK cell activation to impair Treg activity. J Autoimmun. 2020 Feb 5:102417. doi: 10.1016/j.jaut.2020.102417.
2018
Jacobsen LM, Newby BN*, Perry DJ, Posgai AL, Haller, MJ, Brusko TM. Biomarkers, Mechanisms, and Pathways Targeted by Immunotherapies in Type 1 Diabetes. Current Diabetes Reports. 2018; 18(10):19 (*Indicates co-first author)
2017
Yeh WI, Seay HR, Newby B, Posgai AL, Moniz FB, Michels A, Mathews CE, Bluestone JA, Brusko TM. Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes. Front Immunol. 2017;8:1313.
Newby BN, Mathews CE. Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment. Front Endocrinol (Lausanne). 2017;8:232.
Newby BN, Brusko TM, Zou B , Atkinson MA, Clare-Salzler M, Mathews CE. Type 1 Interferons Potentiate Human CD8+ T cell Cytotoxicity Through a STAT4 and Granzyme B Dependent Pathway. Diabetes. 2017;66(12):3061-71.
Driver JP, Racine JJ, Ye C, Lamont DJ, Newby BN, Leeth CM, Chapman HD, Brusko TM, Chen YG, Mathews CE, Serreze DV. Interferon-γ Limits Diabetogenic CD8(+) T-Cell Effector Responses in Type 1 Diabetes. Diabetes. 2017;66(3):710-21.
2016
Delitto D, Delitto AE, DiVita BB, Pham K, Han S, Hartlage ER, Newby BN, Gerber MH, Behrns KE, Moldawer LL, Thomas RM, George T, Brusko T, Mathews CE, Liu C, Trevino JG, Hughes SJ, Wallet S. Human pancreatic cancer cells induce a MyD88-dependent stromal response to promote a tumor-tolerant immune microenvironment. Cancer Res. 2016.
2014
Newby BN, Terada N, Mathews CE. In search of a surrogate: engineering human beta cell lines for therapy. Trends Endocrinol Metab 2014;25:378-80.
2013
Hann, S., Kvenvold, L., Newby, BN, Hong, M. & Warman, M. L. (2013) A Wisp3 Cre-knockin Allele Produces Efficient Recombination in Spermatocytes during Early Prophase of Meiosis I. PLoS ONE 8, e75116. [PMCID: PMC3769254] [PMID: 24040393]
Adams A, McBratney-Owen B, Newby B, Bowen ME, Olsen BR, Warman ML. (2013) Presphenoidal synchondrosis fusion in DBA/2J mice. Mamm Genome. 24(1-2):54-62. [PMCID: PMC3560942]