Deborah G. Murdock, PhD
Deborah G. Murdock, PhD

Deborah G. Murdock, PhD

Deborah G. Murdock, PhD, is a Research Associate Professor of Pediatrics in the Perelman School of Medicine and co-scientific director of the Center for Mitochondrial and Epigenomic Medicine at the Children’s Hospital of Philadelphia.

Areas of expertise: Mitochondrial genetics, Primary mitochondrial disease, Mitochondrial fatty acid synthesis, Mouse models of mitochondrial dysfunction, Mitochondrial dysfunction in common disease

Locations: Colket Translational Research Building


215-590-2920

About Deborah G. Murdock, PhD

Deborah Murdock is an Associate Research Professor in the Perlman School of Medicine at the University of Pennsylvania, and the scientific director of the Center for Mitochondrial and Epigenomic Medicine at the Children’s Hospital of Philadelphia. She has been studying mitochondrial biology for over 25 years. Her main area of research is the mitochondrial fatty acid synthesis pathway, and mitochondrial dysfunction in common diseases. Most recently she has created experimental models of the mitochondrial fatty acid synthesis disorder MEPAN that can be used for testing therapeutics

Titles

Associate Research Professor

Co-Scientific Director, Center for Mitochondrial and Epigenomic Medicine

Education & training

Graduate Degree

PhD in biology - Carnegie Mellon University, Philadelphia, PA

Team affiliations

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Publications

Publications

2023

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts.

Guarnieri JW, Dybas JM, Fazelinia H, Kim MS, Frere J, Zhang Y, Soto Albrecht Y, Murdock DG, Angelin A, Singh LN, Weiss SL, Best SM, Lott MT, Zhang S, Cope H, Zaksas V, Saravia-Butler A, Meydan C, Foox J, Mozsary C, Bram Y, Kidane Y, Priebe W, Emmett MR, Meller R, Demharter S, Stentoft-Hansen V, Salvatore M, Galeano D, Enguita FJ, Grabham P, Trovao NS, Singh U, Haltom J, Heise MT, Moorman NJ, Baxter VK, Madden EA, Taft-Benz SA, Anderson EJ, Sanders WA, Dickmander RJ, Baylin SB, Wurtele ES, Moraes-Vieira PM, Taylor D, Mason CE, Schisler JC, Schwartz RE, Beheshti A, Wallace DC.Sci Transl Med. 2023 Aug 9;15(708):eabq1533. doi: 10.1126/scitranslmed.abq1533. Epub 2023 Aug 9.PMID: 37556555

2019

Host mitochondria influence gut microbiome diversity: A role for ROS.

Yardeni T, Tanes CE, Bittinger K, Mattei LM, Schaefer PM, Singh LN, Wu GD, Murdock DG, Wallace DC.Sci Signal. 2019 Jul 2;12(588):eaaw3159. doi: 10.1126/scisignal.aaw3159.PMID: 31266851

2017

Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity.

Morrow RM, Picard M, Derbeneva O, Leipzig J, McManus MJ, Gouspillou G, Barbat-Artigas S, Dos Santos C, Hepple RT, Murdock DG, Wallace DC.Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2705-2710. doi: 10.1073/pnas.1700997114. Epub 2017 Feb 21.PMID: 28223503 Free PMC article.

2016

Altering the Mitochondrial Fatty Acid Synthesis (mtFASII) Pathway Modulates Cellular Metabolic States and Bioactive Lipid Profiles as Revealed by Metabolomic Profiling.

Clay HB, Parl AK, Mitchell SL, Singh L, Bell LN, Murdock DG.PLoS One. 2016 Mar 10;11(3):e0151171. doi: 10.1371/journal.pone.0151171. eCollection 2016.PMID: 26963735 Free PMC article.

2013

The mitochondrial fatty acid synthesis (mtFASII) pathway is capable of mediating nuclear-mitochondrial cross talk through the PPAR system of transcriptional activation.

Parl A, Mitchell SL, Clay HB, Reiss S, Li Z, Murdock DG.Biochem Biophys Res Commun. 2013 Nov 15;441(2):418-24. doi: 10.1016/j.bbrc.2013.10.072. Epub 2013 Oct 23.PMID: 24161390 Free PMC article.