Kathryn E. Hamilton, PhD
Locations: Main Building
About Kathryn E. Hamilton, PhD
Titles
Researcher
Assistant Professor Pediatrics, Division of Gastroenterology, Liver, and Nutrition, Perelman School of Medicine at the University of Pennsylvania
Awards and Honors
2024, American Gastroenterological Association Young Investigator Award
2022, American Physiological Society Gastrointestinal and Liver Section New Investigator Award
2022, Award for Excellence in Mentoring Research Trainees, Children's Hospital of Philadelphia
2019, Participant, Dr. Edward S. Cooper Leadership Development Program, University of Pennsylvania Perelman School of Medicine
2018, American Gastroenterological Association (AGA) Research Institute Research Policy Committee, Awards Panel Sub-Committee (nomination-based appointment)
2018-2020, American Gastroenterological Association (AGA) Institute Council Nominating Committee Member (elected position)
2016, American Gastroenterological Association (AGA) Women’s Leadership Conference, Dallas, TX
2015, American Society for Investigative Pathology (ASIP) Research Travel Award, Experimental Biology Meeting, Boston, MA
2014, American Physiological Society GI & Liver Section Takeda Travel Award, Experimental Biology Meeting, San Diego, CA
2014, American Gastroenterological Association/American Association for the Study of Liver Diseases Academic Skills Workshop, San Diego, CA
2012, American Gastroenterological Association Research Foundation Horizon Pharma Fellow Abstract Prize Recipient, Freston Conference, Chicago, IL
2010, University of North Carolina Graduate Education Advancement Board Impact Award, Chapel Hill, NC
2009, American Physiological Society GI & Liver Section Research Recognition Award, Experimental Biology Meeting, New Orleans, LA
2009, American Physiological Society GI & Liver Section Graduate Student Poster Competition Award, Experimental Biology Meeting, New Orleans, LA
Leadership and Memberships
Memberships in Professional Organizations
2014-present, Crohn's and Colitis Foundation (CCF)
- 2022-present, Research Training Award Committee
2014-present, Association for Women in Science
2012-present, American Gastroenterological Association
- 2018-present, Foundation Research Awards Panel (Study section member)
- 2017-present, Counsel Abstract Review Committee, Molecular Mechanisms of Growth and Development of the GI Tract, Liver and Pancreas
2009-present,American Physiological Society (APS) Gastrointestinal & Liver Section
- 2021-present, Steering Committee Member (elected position)
- 2017-present, Programming Committee Member
Editorial and Academic Positions
Editorial Positions
2024-present, Associate Editor, Cell and Molecular Gastroenterology and Hepatology
2023-present, Peer reviewer: mBio
2023-present, Peer reviewer: Cell Stem Cell
2019-present, Peer reviewer: Gastroenterology
2018-present, Peer reviewer: Experimental Cell Research
2018-present, Peer reviewer: Biochemistry Journal
2017-present, Peer-reviewer: Cell and Molecular Gastroenterology and Hepatology
2016-present, Peer-reviewer: JCI Insights
2015-present, Peer-reviewer: Molecular Cancer Research
2015-present, Peer-reviewer: Scientific Reports
2012-present, Peer reviewer: American Journal of Physiology, Gastrointestinal and Liver Physiology
2012-present, Editorial Board Member: American Journal of Physiology, Gastrointestinal and Liver Physiology
Academic and Institutional Committees
2020-present, Steering Committee Member, Diversity Postdoc Recruitment "Gateway" Program
2019-present, Office of Faculty Development Advisory Committee
Education & training
Undergraduate Degree
BA in Biology with concentration in Biotechnology - Assumption College, Worcester, MA
Graduate Degree
PhD in Cell and Molecular Physiology - University of North Carolina, Chapel Hill, NC
Fellowship
Postdoctoral Fellow - University of Pennsylvania, Philadelphia, PA
Publications
Publications
2019
Priya Chatterji, Patrick A. Williams, Kelly A. Whelan, Fernando C. Samper, Sarah F. Andres, Lauren A. Simon, Louis R Parham, Rei Mizuno, Emma T. Lundsmith, David S.M. Lee, Shun Liang, H.R. Sagara Wijeratne; Stefanie Marti, Lillian Chau, Veronique Giroux, Benjamin J. Wilkins, Gary D. Wu, Premal Shah, Gian G. Tartaglia, and Kathryn E. Hamilton: Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1. EMBO Reports 20(6): e47074, June 2019.
Sarah F. Andres, Kathy N. Williams, Rei Mizuno, Jeff Headd, Priya Chatterji, Kathryn E. Hamilton, Anil K. Rustgi: IMP1 3' UTR shortening enhances metastatic burden in colorectal cancer. Carcinogenesis 40(4): 569-579, June 2019.
2018
Yuta Kasagia, Prasanna M. Chandramouleeswarana, Kelly A. Whelan, Koji Tanaka, Veronique Giroux, Medha Sharma, Joshua Wang, Alain J. Benitez, Maureen DeMarshall, John W. Tobias, Kathryn E. Hamilton, Gary W. Falk, Jonathan M. Spergel, Andres J. Klein-Szanto, Anil K. Rustgi, Amanda B. Muirb, Hiroshi Nakagawa: The esophageal organoid system reveals functional interplay between Notch and cytokines in reactive epithelial changes. Cell and Molecular Gastroenterology 5(3): 333-352, January 2018.
Rei Mizuno, Priya Chatterji, Sarah F. Andres, Kathryn E. Hamilton, Lauren A. Simon, Shawn Foley, Arjun Jeganathan, Brian Gregory, Blair B. Madison, and Anil K. Rustgi: Differential regulation of LET-7 by LIN28B isoform-specific functions. Molecular Cancer Research 16(3): 403-416, March 2018.
Véronique Giroux, Julien Stephan, Priya Chatterji, Ben Rhoades, Andres J. Klein-Szanto, Christopher J. Lengner, Kathryn E. Hamilton, Anil K. Rustgi: Mouse intestinal krt15+ crypt cells are radio-resistant and tumor-initiating. Stem Cell Reports 10(6): 1947-1958, June 2018.
Priya Chatterji*, Kathryn E. Hamilton*, Shun Liang, Sarah F. Andres, H. R. Sagara Wijeratne, Rei Mizuno, Lauren A. Simon, Philip D. Hicks, Shawn W. Foley, Jason R. Pitarresi, Andres J. Klein-Szanto, Amanda T. Mah, Laurianne Van Landeghem, Brian D. Gregory, Christopher J. Lengner, Blair B. Madison, Premal Shah, and Anil K. Rustgi *co-first author: The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine. Genes and Development 32(15-16): 1020-1034, August 2018.
2017
Giroux V, Lento AA, Islam M, Kharbanda A, Pitaressi JR, Hamilton KE, Whelan KA, Long A, Rhoades B, Tang Q, Nakagawa H, Lengner CJ, Bass AJ, Wileyto EP, Klein-Szanto AJ, Wang TC, Rustgi AK Novel long-lived esophageal progenitor cells contribute to homeostasis and regeneration. Journal of Clinical Investigation. 2017, Jun 1;127(6):2378-2391.
Almohazey D, Lo Y, Vossler C, Simmons A, Hsieh J, Bucar E, Schumacher M, Hamilton KE, Lau K, Shroyer N, Frey M. The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1. Cell Death and Differentiation. 2017, May;24(5):855- 865.
Whelan KA, Merves JF, Giroux V, Tanaka K, Guo A, Chandramouleeswaran PM, Chang S, Benitez AJ, Dods K, Que J, Masterson JC, Fernando SD, Godwin BC, Klein-Szanto AJ, Chikwava K, Ruchelli ED, Hamilton KE, Muir AB, Wang ML, Furuta GT, Falk GW, Spergel JM and Nakagawa H: Autophagy mediates epithelial cytoprotection and redox homeostasis in Eosinophilic Esophagitis. Gut, 2017 Jul;66(7):1197-1207.
2015
Hamilton KE, Chatterji P, Lundsmith ET, Andres SF, Giroux V, Hicks PD, Noubissi FK, Spiegelman VS, Rustgi AK. Stromal loss of mRNA-binding protein Imp1 promotes a tumorigenic microenvironment in the colon. Molecular Cancer Research, 2015, Nov;13(11):1478-86.
Amaravadi RK, Hamilton KE, Ma X, Piao S, Del Portillo A, Nathanson KL, Carlino MS, Georgina V. Long GV, Puzanov I, Xu X, Morrissette JD, Tsai KY, Flaherty KT, Sosman JA, Goodman GR, McArthur GA, Rustgi AK, Metz DC, Schuchter LM, Chapman PB, Sepulveda AR. Multiple gastrointestinal polyps in patients treated with BRAF inhibitors. Clinical Cancer Research, 2015, Dec 1;21(23):5215-21.
Long A, Giroux V, Whelan KA, Hamilton KE, Tetreault MP, Tanaka K, Lee JS, Klein-Szanto AJ, Nakagawa H, Rustgi AK. WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma. Carcinogenesis, 2015 May;36(5)598-606.
2013
Hamilton KE, Noubissi FK, Katti PS, Hahn CM, Davey SR, Lundsmith ET, Klein-Szanto AJ, Rhim AD, Spiegelman VS, Rustgi AK. IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis, 2013, Nov;34(11):2647-54.
2011
Hamilton KE, Simmons JG, Ding S, Van Landeghem L, Lund PK. Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. Molecular Cancer Research, 2011 Dec;9(12):1718-31.
2010
Hamilton KE, Lund PK, Galanko JA, Sandler RS, Keku TO. Suppressor of Cytokine Signaling 3 (SOCS3) Is Not an Independent Biomarker of Colorectal Adenoma Risk. BMC Research Notes, 2010, May 25;3:144.
2006
Louis NA, Hamilton KE, Canny G, Shekels LL, Ho SB, and Colgan SP. Selective induction of Mucin-3 by hypoxia in intestinal epithelia. Journal of Cellular Biochemistry, 2006, Dec 15;99(6):1616-27.
2005
Eltzschig HK, Abdulla P, Hoffman E, Hamilton KE, Daniels D, Schonfeld C, Loffler M, Reyes G, Duszenko M, Karhausen J, Robinson A, Westerman KA, Coe IR, Colgan SP. HIF-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. Journal of Experimental Medicine, 2005, Dec 5;202(11):1493-505.
Louis NA, Hamilton KE, Kong T, and Colgan SP. HIF-dependent induction of apical CD55 coordinates epithelial clearance of neutrophils. FASEB Journal, 2005 Jun 1: 19: 950-959.
Abstracts (includes Posters and Scientific Presentations)
2023
Clara Morral Martinez, Jingya Qiu, Tatiana Karakasheva, Yusen Zhou, Joshua H. Rhoades, Yasin Uzun, Ning Li, Daniel Aleynick, Sarah Weinbrom, Chia-Hui Chen, MaryKate Fulton, Gloria E Soto, Anusha Thadi, Meenakshi Bewtra, Judith R Kelsen, Christopher J Lengner, Kai Tan, Kathryn E Hamilton, Andy J Minn: Deciphering the role of interferon signaling on the acquisition and maintenance of epigenetic memory and its impact on inflammatory bowel disease (Flash talk presentation by trainee) International Society for Stem Cell Research (ISSCR) 2023 Annual Meeting June 2023.
Kaitlyn NaughtonSangeevan VellapanKatharina HayerEmily McMillanYusen ZhouPremal ShahKate Hamilton: RNA methyltransferase METTL3 is essential for genomic integrity and survival of small intestinal stem progenitors (Poster presentation by trainee). International Society for Stem Cell Research (ISSCR) 2023 Annual Meeting June 2023.
2022
Danan C.H., Hayer K. E., Simon L.A., Weitzman, M.D., Hamilton K.E.: N6-Methyladenosine (m6A) Modifies Regenerative Transcripts in the Intestinal Epithelium. Experimental Biology Annual Meeting, Philadelphia, PA April 2022.
Kolcheva A., Karami A., Murray M., Parham L.R., Hamilton K.E., Whelan K.A.: High autophagic vesicle content identifies a novel slow-cycling esophageal basal cell population with stem-like properties (podium presentation by collaborator trainee). Experimental Biology Annual Meeting, Philadelphia, PA April 2022.
Parham L.R., Johnson N.M., Na J, Williams P.A., Whelan K.A., Li N., Lengner C.J., Hamilton K.E.: Autophagic State Confers Facultative Stem Cell Capacity in The Intestinal Epithelium. Experimental Biology Annual Meeting, Philadelphia, PA April 2022.
Charles H. Danan, Katharina E. Hayer, Matthew D. Weitzman, Kathryn E. Hamilton: Colonoids demonstrate RNA regulation by N6-Methyladenosine (m6A) and IMP1 during regeneration (Podium presentation by trainee). American Gastroenterological Associate Freston Conference: Gastrointestinal Organoids and Engineered Organ Systems October 2022.
Noor Nema, Daana M. Roach, Gloria E. Soto, Brooke E. Boyer , Tatiana Karakesheva, Judith R. Kelsen, Kathryn E. Hamilton: Colonoids derived from patients with Tricho-Hepatic-Enteric Syndrome (THES) exhibit atypical morphology and growth (Poster presentation by trainee). American Gastroenterological Associate Freston Conference: Gastrointestinal Organoids and Engineered Organ Systems October 2022.
Tatiana A. Karakasheva, Yusen Zhou, Hongbo M. Xie, Gloria E. Soto, Tiana D. Johnson, Madison Stoltz, Nicole Umeweni, Noor Nema, Louis Ghanem, Natalie Terry, Amanda B. Muir, Kathryn E. Hamilton: Patient derived organoids retain disease-specific transcriptomic signatures and recapitulate the systemic nature of Crohn's disease (Podium presentation by trainee). American Gastroenterological Associate Freston Conference: Gastrointestinal Organoids and Engineered Organ Systems October 2022.
Xianghui Ma, Noor Dawany, Ayano Kondo, Kelly Maurer, Tatiana Karakasheva, Brooke Boyer, Yusen Zhou, Rawan Shraim, Patrick A. Williams, Louis R. Parham, Lauren A. Simon, Maire A. Conrad, Charles H. Danan, Marcella Devoto, Kathleen E. Sullivan, Klaus Kaestner, Judith R. Kelsen, Kathryn E. Hamilton: Defining the role of a novel TNFSF13/APRIL variant in very early onset inflammatory bowel disease (VEO-IBD) (Podium presentation by trainee). American Gastroenterological Associate Freston Conference: Gastrointestinal Organoids and Engineered Organ Systems October 2022.
Nema, Noor; Roach, Daana; Soto, Gloria; Boyer, Brooke; Karakasheva, Tatiana; Kelsen, Judith Rachel; Hamilton, Kathryn E.: Colonoids derived from patients with tricho-hepatic-enteric syndrome (THES) exhibit atypical morphology and growth. North American Society For Pediatric Gastroenterology, Hepatology & Nutrition Annual Meeting, Orlando, FL November 2022.
2021
Madeline Kuhn, Ranjan Preet, Aurora Blucher, John Favate, Sukanya Das, Shun Liang, Louis R Parham, Priya Chatterji, Kathy N Williams, Sudheer Molugu, Wei Zhang, Jiegang Yang, Kathryn E Hamilton, Premal Shah, Gordon Mills, Dan A Dixon, Sarah F Andres: IMP1 Enhances Extracellular Vesicle Secretion in a Transformation-Dependent Manner (podium presentation by collaborator). Experimental Biology Annual Meeting, virtual April 2021.
Patrick A. Williams, Lauren A. Simon, Xianghui Ma, Charles H. Danan, Louis R. Parham, Kathryn E. Hamilton: IGF2BP1/IMP1 regulates translation of autophagy protein LC3 downstream of mTOR in intestinal epithelial cells (podium presentation by trainee). Experimental Biology Annual Meeting, virtual April 2021.
Louis R. Parham, Tatiana Karakasheva, Alena Klochkova, Patrick A. Williams, Xianghui Ma, Lauren A. Simon, Charles H. Danan, Brooke E. Boyer, Kelly A. Whelan, Kathryn E. Hamilton: Posttranscriptional regulation of the autophagy pathway in facultative stem cells contributes to epithelial regeneration (podium presentation by trainee). Digestive Diseases Week, virtual May 2021.
Xianghui Ma, Noor Dawany, Ayano Kondo, Kelly Maurer, Tatiana Karakasheva, Brooke Boyer, Rawan Shraim, Patrick A. Williams, Louis R. Parham, Lauren A. Simon, Maire A. Conrad, Charles H. Danan, Marcella Devoto, Kathleen E. Sullivan, Klaus Kaestner, Judith R. Kelsen, Kathryn E. Hamilton: Defining the role of a novel TNFSF13/APRIL variant in very early onset inflammatory bowel disease (VEO-IBD) (plenary presentation by trainee). Digestive Diseases Week, virtual May 2021.
Lectures by Invitation
2023
Kathryn E. Hamilton. "IMP-lications for cell plasticity in the regenerating intestine", Oregon Health Sciences University Bench to Bedside Seminar Series, Portland, OR. Oct 2023.
Kathryn E. Hamilton. "A Crohn's disease epithelial stem cell atlas reveals sustained inflammatory progenitor cell states", Helmsley Gut Cell Atlas Annual Convening, New York, NY. Sept 2023.
Kathryn E. Hamilton. "Autophagy as a way to identify intestinal stem cell populations", 2023 Digestive Diseases Week, Research Symposium Invited Presentation, Chicago, IL. May 2023.
Kathryn E. Hamilton. "Implicating autophagy in intestinal tissue plasticity", Lancaster University, United Kingdom, Department of Biomedical and Life Sciences, virtual. Feb 2023.
Kathryn E. Hamilton. "Implicating autophagy in intestinal tissue plasticity", Texas Medical Center/Baylor College of Medicine NIH P30 Digestive Diseases Research Center, Houston, TX. Feb 2023.
Kathryn E. Hamilton. "Implicating autophagy in intestinal tissue plasticity", University of Illinois, Chicago, Department of Medicine, Division of Gastroenterology and Hepatology, virtual. Jan 2023.
2022
Kathryn E. Hamilton. "Using Organoids to Study Pediatric Inflammatory Bowel Disease", 2022 James W. Freston Conference: Gastrointestinal Organoids and Engineered Organ Systems, Research Symposium Invited Presentation, Washington, DC. Oct 2022.
Kathryn E. Hamilton. "Understanding Intestinal Epithelial Stem Cells in Children and Adults with Crohn's Disease", Helmsley Charitable Trust Gut Cell Atlas Annual Convening, Research Symposium Invited Presentation, New York, NY. Sept 2022.
Kathryn E. Hamilton. "Dynamic Regulation of Intestinal Tissue Repair via RNA Binding Protein IMP1/IGF2BP1", Gordon Research Conference: Post-transcriptional Gene Regulation, Invited Presentation, Sunday River, ME. Jul 2022.
Kathryn E. Hamilton. "Understanding durable epithelial changes in pediatric inflammatory bowel disease", 2022 Digestive Diseases Week, Research Forum Invited Presentation, San Diego, CA. May 2022.
Kathryn E. Hamilton. "IMP-lications for post-transcriptional gene regulation in intestinal epithelial homeostasis", Experimental Biology Annual Meeting, Research Symposium Invited Presentation, Philadelphia PA. Apr 2022.
2021
Kathryn E. Hamilton. "IMP-licating RNA binding proteins in intestinal epithelial regeneration", RNA Society's RNA Collaborative Seminar Series, virtual. Dec 2021.