Dustin Flannery, DO, MSCE
Areas of expertise: Neonatal-perinatal medicine
Locations: Main Building, CHOP at Penn Medicine Pennsylvania Hospital
About Dustin Flannery, DO, MSCE
Dustin Daniel Flannery, DO, MSCE, is an attending neonatologist at the Children’s Hospital of Philadelphia (CHOP) and CHOP Newborn Care at Pennsylvania Hospital, an Assistant Professor of Pediatrics at the University of Pennsylvania Perelman School of Medicine, and a core faculty member in CHOP Clinical Futures. He received a Doctor of Osteopathic Medicine degree from the Philadelphia College of Osteopathic Medicine and a Bachelor of Science with Honors from Virginia Tech. After completing a residency and chief residency in Pediatrics at Nemours A.I. duPont Hospital for Children/Thomas Jefferson University Hospital, he completed a fellowship in Neonatal-Perinatal Medicine at CHOP. He graduated from the CHOP Pediatric Hospital Epidemiology and Outcomes Research Training program and the Master of Science in Clinical Epidemiology program at the University of Pennsylvania.
In addition to caring for critically ill newborns and their families, Dr. Flannery is a clinical epidemiologist. He uses a variety of data sources to study perinatal infection epidemiology, with a focus on early-onset sepsis, and neonatal pharmacoepidemiology, with an emphasis on antimicrobial stewardship. Dr. Flannery is particularly interested in neonatal intensive care unit antimicrobial prescription practices and how the global threat of antimicrobial resistance may impede our ability to treat infections in this vulnerable population. He has received research funding from CHOP, the National Institute of Child Health and Human Development (T32), the Agency for Healthcare Research and Quality (K08), and the Centers for Disease Control and Prevention.
Dr. Flannery actively participates in undergraduate and graduate medical education. He is the Director of Pediatric Trainee Education at Pennsylvania Hospital and is the PSOM clerkship director for the well nursery and intensive care nursery elective rotations. He also serves as the site director at Pennsylvania Hospital for the CHOP Neonatology and Pediatric Hospital Medicine fellowship programs.
Titles
Attending Neonatologist
Assistant Professor of Pediatrics, University of Pennsylvania Perelman School of Medicine
Director of Pediatric Trainee Education, Pennsylvania Hospital Newborn Care
Certifications
Neonatal-Perinatal Medicine – American Board of Pediatrics
Pediatrics – American Board of Pediatrics
Awards and Honors
2023, Alpha Omega Alpha (AΩA) Medical Honor Society, Perelman School of Medicine, University of Pennsylvania
2022, Alumni Pillar Award, Philadelphia College of Osteopathic Medicine Office of Alumni Engagement
2022, PIDS Top Abstract, Pediatric Academic Societies Meeting
2021, Relationship Based Care Physician Award, Shared Governance Advisory Council and Nursing Leadership, Pennsylvania Hospital
2020, Neonatal Abstinence Syndrome Quality Care Subaward: Pennsylvania Hospital Newborn Medicine, Pennsylvania Perinatal Quality Collaborative
2019, Alumni Professional Development Grant Award, Philadelphia College of Osteopathic Medicine Alumni Association
2019, Trainee Travel Grant Award, Pediatric Academic Societies Meeting
2019, Young Investigator Coaching Program (Coach: Dr. Thomas Newman), Society for Pediatric Research
2018, Thomas Boggs Perinatal-Neonatal Fellow Research Award Finalist, Philadelphia Perinatal Society
2017, Excellence in Clinical Research Award, Children’s Hospital of Philadelphia Research Institute
2017, Trainee Travel Grant Award, Eastern Society for Pediatric Research Meeting
2016, Quality and Patient Safety Honorable Mention: Supporting Premature Infant Nutrition (SPIN), Penn Medicine Clinical Effectiveness and Quality Improvement Initiative
2016, Antimicrobial Stewardship Fellowship Award, Pediatric Infectious Diseases Society
2015, Section on Infectious Diseases Travel Grant Award, American Academy of Pediatrics
2014, Rosenblum Award for Excellence (Outstanding Senior Resident), Alfred I. duPont Hospital for Children
2014, Bambi Taylor, M.D. Pediatric Emergency Medicine Award, Alfred I. duPont Hospital for Children
Leadership and Memberships
Memberships in Professional Organizations
International
2018-present, International Society of Evidence-Based Neonatology (EBNEO)
National
2018-present, Society for Healthcare Epidemiology of America
2018-present, PIDS Pediatric Committee on Antimicrobial Stewardship
2018-present, CDC/VON Antimicrobial Stewardship Special Interest Group
2016-2018, Liaison, AAP Section on Breastfeeding/Section on Pediatric Trainees
2015-present, Society for Pediatric Research (SPR)
2013-present, Pediatric Infectious Diseases Society (PIDS)
2013-present, Academic Pediatric Association (APA)
2011-present, American Academy of Pediatrics (AAP)
Editorial and Academic Positions
Editorial Positions
Ad Hoc Reviewer
2022-present, GERMS
2021-present, JAMA Network Open
2021-present, Journal of Pediatrics
2021-present, The American Journal of Obstetrics & Gynecology (AJOG)
2021-present, Pediatric Pulmonology
2020-present, Archives of Disease in Childhood
2020-present, Lancet Infectious Diseases
2020-present, Scientific Reports
2020-present, BMJ Paediatrics Open
2019-present, Journal of Perinatology
2017-present, The Pediatric Infectious Disease Journal
2017-present, Journal of the Pediatric Infectious Diseases Society
2016-present, Virulence
2016-present, American Journal of Perinatology
2015-present, Pediatrics
Invited Reviewer
2022, Proposal Peer Reviewer, United Kingdom Research and Innovation Medical Research Council
2021, Proposal Peer Reviewer, Thrasher Research Fund
2019, Reviewer, Pediatric Infectious Diseases Society Antimicrobial Stewardship Fellowship Award
2019, Judge, Philadelphia College of Osteopathic Medicine Research Poster Day
2019, Abstract Reviewer, American Academy of Pediatrics National Conference and Exhibition
2016-present, Abstract Reviewer, Pediatric Academic Societies Annual Meeting Scientific
Academic and Institutional Committees
2022-present, Coworker Observation Reporting System (CORS) Group, Pennsylvania Hospital
2019-present, Neonatology Scientific Review Committee, Children’s Hosp. of Philadelphia
2019-present, Pediatric Sepsis Program, Children’s Hosp. of Philadelphia
2018-present, UTI Management Pathway Development Team, Children’s Hosp. of Philadelphia
2017-present, Neonatology Fellowship Selection Committee
Education & training
Graduate Degree
MS in Clinical Epidemiology (MSCE) - University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Medical Degree
DO - Philadelphia College of Osteopathic Medicine, Philadelphia, PA
Internship
Pediatrics - Nemours Alfred I duPont Hospital for Children/Thomas Jefferson University, Philadelphia, PA
Residency
Pediatrics - Nemours Alfred I duPont Hospital for Children/Thomas Jefferson University, Philadelphia, PA (Chief Resident)
Fellowship
Neonatal-Perinatal Medicine - Children's Hospital of Philadelphia, PA (Chief Fellow)
Publications
Publications
2024
Prochaska EC, Xiao S, Colantuoni E, Clark RH, Johnson J, Mukhopadhyay S, Kalu IC, Zerr DM, Reich PJ, Roberts J, Flannery DD, Milstone AM. Hospital-Onset Bacteremia among NICU Patients: Epidemiology, Clinical Characteristics and Mortality. JAMA Pediatr. 2024 Jun 24 [Epub ahead of print]; PubMed PMID: 38913368.
Gottschalk A, Coggins SA, Dhudasia MB, Flannery DD, Healy T, Puopolo KM, Gerber JS, Mukhopadhyay S. Utility of Anaerobic Blood Cultures in Neonatal Sepsis Evaluation. J Ped Inf Dis Soc. 2024 Jun 1; [Epub ahead of print]
Zevallos Barboza, A; Flannery DD, Shu D, Galloway M, Dhudasia MB, Bonafide CP, Benitz WE, Gerber JS, Mukhopadhyay S. Trends in C-Reactive Protein Use in Early-Onset Sepsis Evaluations and Associated Antibiotic Use. J Pediatr. 2024 Jun 18;273:114153. [Epub ahead of print]
Flannery DD, Zevallos Barboza A, Mukhopadhyay S, Gerber JS, McDonough M, Shu D, Hennessy S, Wade KC, Puopolo KM. Antibiotic use among extremely low birth-weight infants from 2009 to 2021: a retrospective observational study. Arch Dis Child Fetal Neonatal Ed. 2024 Jul 20. [Epub ahead of print]
Olivieri NR, Othman L, Flannery DD, Gordon SM. Transmission, seroprevalence, and maternal-fetal impact of lymphocytic choriomeningitis virus. Pediatr Res. 2024 Jan;95(2):456-463.
Flannery DD, Puopolo KM. EBNEO Commentary: Safety and immunogenicity of GBS vaccine in pregnancy and determination of a serocorrelate for infant protection. Acta Paediatr. 2024 Jan;113(1):157-158
Flannery DD, Coggins SA, Medoro AK. Antibiotic Stewardship in the Neonatal Intensive Care Unit. J Intensive Care Med. 2024 Jun 5;8850666241258386. [Epub ahead of print] Review. PubMed PMID: 38835250.
Flannery DD, Shah NC, Puopolo KM. Perinatal COVID-19: Implications for care of the newborn. Semin Perinatol. 2024 Jun;48(4):151921. doi: 10.1016/j.semperi.2024.151921. Epub 2024 Jun 6. Review. PubMed
2023
Flannery DD, Zevallos Barboza A, Mukhopadhyay S, Wade KC, Gerber JS, Shu D, Puopolo KM. Antibiotic use among infants admitted to neonatal intensive care units from 2009 to 2021. JAMA Pediatr. 2023 Dec 1;177(12):1354-1356. PubMed PMID: 37812442. PubMed Central PMCID: PMC10562984.
Flannery DD, Zevallos Barboza A, Wade KC, Pfeifer MR, Gerber JS, Morris JS, Puopolo KM. Measles Serostatus Among Parturient Patients at 2 Philadelphia Hospitals in 2021. JAMA. 2023 Feb 28;329(8):682-684. PubMed PMID: 36735270. PubMed Central PMCID: PMC9975922.
Flohr SJ, Land DS, Hedrick HL, Rintoul NE, Swami SK, Flannery DD. Synthetic Patch Infection after Congenital Diaphragmatic Hernia Repair: A Case Series. J Pediatr Surg Case Rep. 2023; 90:102583. https://doi.org/10.1016/j.epsc.2023.102583.
Wallace B, Chang D, O’Malley Olsen E, Flannery DD, Tong V, Ellington S, Woodworth K. Critical care among newborns with and without a COVID-19 diagnosis, May 2020–February 2022. J Perinatol. 2023 Jun;43(6):766-774. PubMed PMID: 37117394. PubMed Central PMCID PMC10141806.
Proaño A, Flannery DD. EBNEO Commentary: Respiratory syncytial virus vaccine in pregnancy for infant protection. Acta Paediatr. 2023 Nov;112(11):2449-2450.
2022
Flannery DD, Puopolo KM, Hansen NI, Gerber JS, Sánchez PJ, Stoll BJ, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Antimicrobial Susceptibility Profiles Among Neonatal Early-Onset Sepsis Pathogens. Pediatr Infect Dis J. 2022; 41(3):263-271.
Flannery DD, Mukhopadhyay S, Morales KH, Dhudasia MB, Passarella M, Gerber JS, Puopolo KM. Delivery Characteristics and the Risk of Early-Onset Neonatal Sepsis. Pediatrics. 2022;149(2):e2021052900.
O'Leary EN, Edwards JR, Srinivasan A, Neuhauser MM, Soe MM, Webb AK, Edwards EM, Horbar JD, Soll RF, Roberts J, Hicks LA, Wu H, Zayack D, Braun D, Cali S, Edwards WH, Flannery DD, Fleming-Dutra KE, Guzman-Cottrill JA, Kuzniewicz M, Lee GM, Newland J, Olson J, Puopolo KM, Rogers SP, Schulman J, Septimus E, Pollock DA. National Healthcare Safety Network 2018 Baseline Neonatal Standardized Antimicrobial Administration Ratios. Hosp Pediatr. 2022 Feb 1;12(2):190-198. doi: 10.1542/hpeds.2021-006253.
Mukhopadhyay S, Briker SM, Flannery DD, Dhudasia MB, Coggins SA, Woodford E, Walsh EM. Li S, Puopolo KM, Kuzniewicz MW. Time to Positivity of Blood Cultures in Neonatal Late-Onset Bacteremia. Arch Dis Child – Fetal Neonat Ed. 2022 Nov;107(6):583-588.
Burris HH, Mullin AM, Dhudasia MB, Flannery DD, Mukhopadhyay S, Pfeifer MR, Woodford EC, Briker SM, Triebwasser JE, Morris JS, Montoya-Williams D, Gouma S, Hensley SE, Puopolo KM. Neighborhood Characteristics and Racial Disparities in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seropositivity in Pregnancy. Obstet Gynecol. Obstet Gynecol. 2022 Jun 1;139(6):1018-1026. doi: 10.1097/AOG.0000000000004791. Epub 2022 May 2.
Flannery DD, Passarella M, Mukhopadhyay S, Dhudasia MB, Gerber JS, Lorch SA, Hennessy S, Puopolo KM. Early Childhood Antibiotic Utilization for Infants Discharged from the Neonatal Intensive Care Unit. J Perinatol. 2022 Jul;42(7):953-958. doi: 10.1038/s41372-022-01380-y.
Puopolo KM, Mukhopadhyay S, Hansen NI, Flannery DD, Greenberg RG, Sanchez PJ, Bell EF, DeMauro SB, Wyckoff MH, Eichenwald EC, Stoll BJ, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Group B Streptococcal Infection in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years. Clin Infect Dis. 2022 Oct 12;75(8):1405-1415.
Triebwasser JE, Dhudasia MB, Mukhopadhyay S, Flannery DD, Gouma S, Hensley SE, Puopolo KM. Assessment of SARS-CoV-2 serostatus and hypertensive disorders of pregnancy. Am J Obstet Gynecol. 2022 Oct;227(4):664-666.e1. doi: 10.1016/j.ajog.2022.06.012.
Flannery DD, Zevallos Barboza A, Pfeifer MR, Hudak ML, Barnette K, Getzlaff T, Ellington SR, Woodworth KR, Dhudasia MB, Mukhopadhyay S, Weinberg DD, Foglia EE, Puopolo KM. Perinatal COVID-19 maternal and neonatal outcomes at two academic birth hospitals. J Perinatol. 2022 Oct;42(10):1338-1345. doi: 10.1038/s41372-022-01446-x.
Flannery DD, Edwards EM, Coggins SA, Horbar JD, Puopolo KM. Late-Onset Sepsis Among Very Preterm Infants. Pediatrics. 2022;150(6):e2022058813.
Coggins SA, Edwards EM, Flannery DD, Gerber JS, Horbar JD, Puopolo KM. Serratia infection epidemiology among very preterm infants in the neonatal intensive care unit.Pediatr Infect Dis J. 2023 Feb 1;42(2):152-158.
Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Briker SM, Triebwasser JE, Gerber JS, Morris JS, Weirick ME, McAllister CM, Hensley SE, Puopolo KM. Comparison of Maternal and Neonatal Antibody Levels After COVID-19 Vaccination vs SARS-CoV-2 Infection. JAMA Netw Open. 2022;5(11):e2240993.
Hudak ML, Flannery DD, Barnette K, Getzlaff T, Gautam S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Ellington SR, Galang RR, Snead MC, Woodworth KR, Zapata LB, Puopolo KM, on behalf of the American Academy of Pediatrics NPC-19 Registry Investigators. Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry. Pediatrics. 2023;151(2):e2022059595.
Dhudasia MB, Benitz WE, Flannery DD, Christ L, Rub D, Remaschi G, Puopolo KM, Mukhopadhyay S. Diagnostic performance and patient outcomes with C-reactive protein use in early-onset sepsis evaluations. J Pediatr. 2022 Dec 16;S0022-3476(22)01123-4.
Flannery DD, Chiotos K, Gerber JS, Puopolo KM. Neonatal multidrug resistant gram-negative infection: epidemiology, mechanisms of resistance, and management. Pediatr Res. 2022; 91(2):380-391.
Flannery DD, Puopolo KM, Hansen NI, Sánchez PJ, Stoll BJ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neonatal infections: Insights from a multicenter longitudinal research collaborative. Semin Perinatol. 2022 Nov;46(7):151637. doi: 10.1016/j.semperi.2022.151637. Epub 2022 Jun 10.
Flannery DD, Puopolo KM. Neonatal Early-Onset Sepsis. Neoreviews, American Academy of Pediatrics. 2022 Nov 1;23(11):756-770. doi: 10.1542/neo.23-10-e756.
Flannery DD, Puopolo KM. The imperfect science of neonatal sepsis. Pediatr Res. Pediatr Res. 2022 Mar;91(4):733-734. doi: 10.1038/s41390-021-01863-2.
2021
Garber SJ, Dhudasia MB, Flannery DD, Passarella MR, Puopolo KM, Mukhopadhyay S. Delivery-based criteria for empiric antibiotic administration among preterm infants. J Perinatol. 2021 Feb;41(2):255-262.
Flannery DD, Jensen EA, Tomlinson LA, Yu Y, Ying GS, Binenbaum G. Poor postnatal weight growth is a late finding after sepsis in very preterm infants. Arch Dis Child Fetal Neonatal Ed. 2021 May;106(3):298-304.
Flannery DD, Akinboyo IC, Mukhopadhyay S, Tribble AC, Song L, Chen F, Li Y, Gerber JS, Puopolo, KM. Antibiotic Susceptibility of Escherichia coli Among Infants Admitted to Neonatal Intensive Care Units Across the US from 2009 to 2017. JAMA Pediatr. 2021 Feb 1;175(2):168-175.
Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Triebwasser JE, Gerber JS, Morris JS, Weirick ME, McAllister CM, Bolton MJ, Arevalo CP, Anderson EM, Goodwin EC, Hensley SE, Puopolo KM. Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios. JAMA Pediatr. 2021 Jun 1;175(6):594-600.
Montoya-Williams D, Mullin AM, Handley SC, Flannery DD, Lorch SA, Elovitz MA, Burris HH. Disparities in SARS-CoV-2 positivity among pregnant patients with limited English proficiency. J Perinatol. 2021 Oct;41(10):2564-2565.
Flannery DD, Edwards EM, Puopolo KM, Horbar JH. Early-Onset Sepsis Among Very Preterm Infants. Pediatrics. 2021 Oct;148(4):e2021052456.
Flannery DD, Puopolo KM. Perinatal COVID-19: guideline development, implementation, and challenges. Curr Opin Pediatr. 2021 Apr 1;33(2):188-194.
Dhudasia MD, Flannery DD, Pfeifer MR, Puopolo KM. Updated Guidance: Prevention and Management of Perinatal Group B Streptococcus Infection. American Academy of Pediatrics NeoReviews 2021 Mar;22(3):e177-e188.
Flannery DD, Wade KC. Immunization in the Neonatal Intensive Care Unit. Clin Perinatol. 2021 Jun;48(2):393-412.
2020
Gordon SM, Srinivasan L, Taylor DM, Master SR, Tremoglie MA, Hankeova A, Flannery DD, Abbasi S, Fitzgerald JC, Harris MC. Derivation of a metabolic signature associated with bacterial meningitis in infants. Pediatr Res. 2020 Aug;88(2):184-191.
Flannery DD, Mukhopadhyay S, Jensen EA, Gerber JS, Passarella MR, Dysart K, Aghai ZH, Greenspan J, Puopolo KM. Influence of Patient Characteristics on Antibiotic Use Rates Among Preterm Infants. J Pediatric Infect Dis Soc. 2021 Mar 26;10(2):97-103.
Bamat NA, Ekhaguere OA, Zhang L, Flannery DD, Handley SC, Herrick HM, Ellenberg SS. Protocol adherence rates in superiority and noninferiority randomized clinical trials published in high impact medical journals. Clin Trials. 2020 Oct;17(5):552-559.
Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Gerber JS, Arevalo CP, Bolton MJ, Weirick ME, Goodwin EC, Anderson EM, Greenplate AR, Kim J, Han N, Pattekar A, Dougherty J, Kuthuru O, Mathew D, Baxter AE, Vella LA, Weaver J, Verma A, Leite R, Morris JS, Rader DJ, Elovitz MA, Wherry EJ, Puopolo KM, Hensley SE. SARS-CoV-2 seroprevalence among parturient women in Philadelphia. Sci Immunol. 2020 Jul 29;5(49):eabd5709.
Flannery DD, Horbar JD. Metrics of Neonatal Antibiotic Use. Semin Perinatol. 2020 Dec;44(8):151329. PubMed PMID: 33158602.