Ilia Fishbein, MD, PhD

2020

Inamdar VV, Fitzpatrick EG, Alferiev IS, Levy RJ, Stachelek SJ, Fishbein I: Mitigation of blood borne cell attachment to metal implants through CD47-derived peptide immobilization. Journal of Visualized Experiments(166), Dec 3 2020 Notes: doi: 10.3791/61545.

Inamdar Vaishali V, Fitzpatrick Emmett, Alferiev Ivan, Nagaswami Chandrasekaran, Spruce Lynn A, Fazelinia Hossein, Bratinov George, Seeholzer Steven H, Levy Robert J, Fishbein Ilia, Stachelek Stanley J: Stability and bioactivity of pepCD47 attachment on stainless steel surfaces. Acta biomaterialia 104: 231-240, Mar 2020 Notes: NIHMS ID 1583105.

Battig MR, Alferiev IS, Guerrero DT, Fishbein I, Pressly BB, Levy RJ, Chorny M: An Experimental Single-Platform Approach to Enhance Functionalization of Magnetically Targetable Cells. ACS Applied Bio Materials 2020 Notes: accepted; mt-2020-00466a.R1; DOI: 10.1021/acsabm.0c00466; NIHMS1597029.

2018

Battig Mark R, Fishbein Ilia, Levy Robert J, Alferiev Ivan S, Guerrero David, Chorny Michael: Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system. Drug delivery and translational research 8(4): 954-963, Aug 2018.

2017

Fishbein I, Guerrero DT, Alferiev IS, Foster JB, Minutolo NG, Chorny M, Monteys AM, Driesbaugh KH, Nagaswami C, Levy RJ: Stent-based delivery of adeno-associated viral vectors with sustained vascular transduction and iNOS-mediated inhibition of in-stent restenosis. Gene Ther 24(11): 717-726, Nov 2017.

2016

Fishbein I, WelchT ,Guerrero DT ,Alferiev IS ,Adamo RF , Chorny M, Gupte RK, Tang Y, Levy RJ: Paraffin Processing of Stented Arteries Using a Post-Fixation Dissolution of Metallic and Polymeric Stents. Cardiovascular Pathology. 2016 Aug 20;25(6):483-488. PMID: 27616613 (eds.). 25(6): 483-488, Aug 2016.

Slee JB, Alferiev IS, Nagaswami C, Weisel JW, Levy RJ, Fishbein I, Stachelek SJ: Enhanced biocompatibility of CD47-functionalized vascular stents. Biomaterials 87: 82-92, Feb 2016 Notes: joint senior author. PMCID: NIHMS762654

Adamo RF, Fishbein I, Zhang K, Wen J, Levy RJ, Alferiev IS, Chorny M.: Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries. Journal of Controlled Release 222: 169-175, Jan 2016 Notes: joint first author. PMCID: PMC4718792

2015

Alferiev IS, Iyer R, Croucher JL, Adamo RF, Zhang K, Mangino JL, Kolla V, Fishbein I, Brodeur GM, Levy RJ, Chorny M: Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials 51(1): 22-29, May 2015.

2014

Tengood JE, Alferiev IS, Zhang K, Fishbein I, Levy RJ, Chorny M: Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media. PNAS 111(11): 4245-4250, Mar 2014.

Fishbein I, Forbes SP, Adamo RF, Chorny M, Levy RJ, Alferiev IS: Vascular gene transfer from metallic stent surfaces using adenoviral vectors tethered through hydrolysable cross-linkers. Journal of Visualized Experiments(90), e51653, Aug 2014 Notes: doi:10.3791/51653; http://www.jove.com/video/51653.

Kruklitis RJ, Fishbein I, Singhal S, Kappor V, Levy RJ, Alferiev IS, Sterman DH: Stent-mediated gene delivery for site-specific transgene administration to the airway epithelium and management of tracheobronchial tumors. Respiration 88(5): 406-417, Nov 2014 Notes: joint first authorship.

2013

Ma G, Wang Y, Fishbein I, Yu M, Zhang L, Alferiev IS, Yang J, Song C, Levy RJ: Anchoring of self-assembled plasmid DNA/anti-DNA antibody/cationic lipid micelles on bisphosphonate-modified stent for cardiovascular gene delivery. International J Nanomedicine 8: 1029-35, Mar 2013.

Chorny M, Fishbein I, Tengood JE, Adamo RF, Alferiev IS, Levy RJ: Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors. FASEB journal  27(6): 2198-206, Jun 2013.

Fishbein I, Forbes SP, Chorny M, Connolly JM, Adamo RF, Corrales RA, Alferiev IS, Levy RJ: Adenoviral vector tethering to metal surfaces via hydrolyzable cross-linkers for the modulation of vector release and transduction. Biomaterials 34(28): 6938-48, Sep 2013.

Forbes SP,  Alferiev IS,  Chorny M,  Adamo RF,  Levy RJ,  Fishbein I: Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: Implications for gene therapy of restenosis. Atherosclerosis 230(1): 23-32, Sep 2013.

2012

Chorny M, Alferiev IS, Fishbein I, Tengood JE, Folchman-Wagner Z, Forbes SP, Levy RJ: Formulation and in vitro characterization of composite biodegradable magnetic nanoparticles for magnetically guided cell delivery. Pharmaceutical research 29(5): 1232-41, May 2012.

2010

Chorny M, Fishbein I, Yellen BB, Alferiev IS, Bakay M, Ganta S, Adamo RF, Amiji M, Friedman G, Levy RJ: Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields. PNAS (Proceedings of the National Academy of Sciences of the United States of America) 107(18): 8346-51, May 2010 Notes: joint first authorship.

2009

Chorny M, Fishbein I, Alferiev IS, Levy RJ: Magnetically responsive biodegradable nanoparticles enhance adenoviral gene transfer in cultured smooth muscle and endothelial cells. Molecular pharmaceutics 6(5): 1380-7, Sep-Oct 2009.

2008

Polyak B, Fishbein I, Chorny M, Alferiev IS, Williams D, Yellen BB, Friedman G, Levy RJ: High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents. PNAS (Proceedings of the National Academy of Sciences of the United States of America) 105(2): 698-703, Jan 2008 Notes: joint first authorship.

Fishbein I, Alferiev IS, Bakay M, Stachelek SJ, Sobolewski P, Lai M, Choi H, Chen I-W, Levy RJ: Local delivery of gene vectors from bare-metal stents by use of a biodegradable synthetic complex inhibits in-stent restenosis in rat carotid arteries. Circulation 117(16): 2096-103, Apr 2008.

2006

Fishbein I, Alferiev IS, Nyanguile O, Gaster R, Vohs JM, Wong GS, Felderman H, Chen I-W, Choi H, Wilensky RL, Levy RJ: Bisphosphonate-mediated gene vector delivery from the metal surfaces of stents. PNAS (Proceedings of the National Academy of Sciences of the United States of America) 103(1): 159-64, Jan 2006.

Chorny M, Fishbein I, Alferiev IS, Nyanguile O, Gaster R, Levy RJ: Adenoviral gene vector tethering to nanoparticle surfaces results in receptor-independent cell entry and increased transgene expression. Molecular therapy  14(3): 382-91, Sep 2006 Notes: joint first authorship.

2005

Banai S, Chorny M, Gertz SD, Fishbein I, Gao J, Perez L, Lazarovichi G, Gazit A, Levitzki A, Golomb G.: Locally delivered nanoencapsulated tyrphostin (AGL-2043) reduces neointima formation in balloon-injured rat carotid and stented porcine coronary arteries. Biomaterials 26(4): 451-461, Feb 2005.

2003

Burton DY, Song C, Fishbein I, Hazelwood S, Li Q, DeFelice S, Connolly JM, Perlstein I, Coulter DA, Levy RJ.: The incorporation of an ion channel gene mutation associated with the long QT syndrome (Q9E-hMiRP1) in a plasmid vector for site-specific arrhythmia gene therapy: in vitro and in vivo feasibility studies. Hum Gene Ther 14(9): 907-922, Jun 2003.

Danenberg HD, Fishbein I, Epstein H, Waltenberger J, Moerman E, Monkkonen J, Gao J, Gathi I, Reichi R, Golomb G.: Systemic depletion of macrophages by liposomal bisphosphonates reduces neointimal formation following balloon-injury in the rat carotid artery. J Cardiovasc Pharmacol 42(5): 671-679, Nov 2003.

2002

Danenberg HD, Fishbein I, Gao J, Monkkonen J, Reich R, Gati I, Moerman E, Golomb G.: Macrophage depletion by clodronate-containing liposomes reduces neointimal formation after balloon injury in rats and rabbits. Circulation 106(5): 599-605, Jul 2002.

Margolin L, Fishbein I, Banai S, Golomb G, Reich R, Perez LS, Gertz SD.: Metalloproteinase inhibitor attenuates neointima formation and constrictive remodeling after angioplasty in rats: augmentative effect of alpha(v)beta(3) receptor blockade. Atherosclerosis 163(2): 269-277, Aug 2002.

Chorny M, Fishbein I, Danenberg HD, Golomb G.: Lipophilic drug loaded nanospheres prepared by nanoprecipitation: effect of formulation variables on size, drug recovery and release kinetics. J Control Release 83(3): 389-400, Oct 2002.

Chorny M, Fishbein I, Danenberg HD, Golomb G.: Study of the drug release mechanism from tyrphostin AG-1295-loaded nanospheres by in situ and external sink methods. J Control Release 83(3): 401-414, Oct 2002.

Karck M, Meliss R, Hestermann M, Mengel M, Pethig K, Levitzki A, Banai S, Golomb G, Fishbein I, Chorny M, Haverich A.: Inhibition of aortic allograft vasculopathy by local delivery of platelet-derived growth factor receptor tyrosine-kinase blocker AG-1295. Transplantation 74(9): 1335-1341, Nov 2002.

Alferiev IS, Fishbein I.: Activated polyurethane modified with latent thiol groups. Biomaterials 23(24): 4753-4758, Dec 2002.

2001

Fishbein I, Chorny M, Banai S, Levitzki A, Danenberg HD, Gao J, Chen X, Moerman E, Gati I, Goldwasser V, Golomb G.: Formulation and delivery mode affect disposition and activity of tyrphostin-loaded nanoparticles in the rat carotid model. Arterioscler Thromb Vasc Biol 21(9): 1434-1439, Sep 2001.

Fishbein I, Brauner R, Chorny M, Gao J, Chen X, Laks H, Golomb G.: Local delivery of mithramycin restores vascular reactivity and inhibits neointimal formation in injured arteries and vascular grafts. J Control Release 77(3): 167-181, Dec 2001.

2000

Fishbein I, Chorny M, Rabinovich L, Banai S, Gaty I, Golomb G.: Nanoparticulate delivery system of a tyrphostin for the treatment of restenosis. J Control Release 65(1-2): 221-229, Mar 2000.

Fishbein I, Waltenberger J, Rabinovich L, Chorny M, Banai S, Levitzki A, Gazit A, Huber R, Hertz SD, Golomb G.: Local delivery of PDGF-receptor-specific tyrphostin inhibits neointimal formation in rats. Arterioscler Thromb Vasc Biol 20(3): 667-676, Mar 2000.

Cohen H, Levy RJ, Gao J, Fishbein I, Kousaev V, Sosnowski S, Slomkowski S, Golomb G.: Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles. Gene Ther 7(22): 1896-1905, Nov 2000.

1998

Banai S, Wolf Y, Golomb G, Pearle A, Waltenberger J, Fishbein I, Schneider A, Gazit A, Perez L, Huber R, Lazarovichi G, Rabinovich L, Levitzki A, Gertz SD.: PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine. Circulation 97(19): 1960-1969, May 1998.

1997

Brauner R, Lax H, Drinkwater DC, Chaudhuri G, Shvartz O, Drake T, Bhuta S, Mishaly D, Fishbein I, Golomb G.: Controlled periadventitial administration of verapamil inhibits neointimal smooth muscle cell proliferation and ameliorates vasomotor abnormalities in experimental vein bypass grafts. J Thorac Cardiovasc Surg 114(1): 53-63, Jul 1997.

Mishaly D, Fishbein I, Moscovitz D, Golomb G.: Site-specific delivery of colchicine in rat carotid artery model of restenosis. J Control Release 45(1): 65-73, Mar 1997.

1996

Golomb G, Fishbein I, Banai S, Mishaly D, Moscovitz D, Gertz SD, Gazit A, Poradosu E, Levitzki A.: Controlled delivery of a tyrphostin inhibits intimal hyperplasia in a rat carotid artery model. Atherosclerosis 125(2): 171-182, Sep 1996.

2014

Tengood JE, Fishbein I, Levy RJ, Chorny M: Nanomedicines for restenosis treatment. Handbook of Nanobiomedical Research. World Scientific Publishing, Page: 39-87, Oct 2014 Notes: Chapter 2.

2012

Fishbein I, Chorny M, Alferiev IS, Levy RJ: Site specific controlled release for cardiovascular disease - translational directions. Fundamentals and Applications of Controlled Release Drug Delivery. J. Siepmann, M. J.Rathbone, R. A. Siegal (eds.). Springer, Page: 445-492, Nov 2012.

2005

Fishbein I, Perlstein I, Levy RJ.: Gene therapy stents. In: Polymeric Gene Delivery: Principles and Applications. Mansoor M. Amiji (eds.). CRC Press, Page: 625-658, Oct 2005.

1999

Fishbein I, Chorny M, Gaty I, Rabinovich L, Golomb G.: Delivery systems for the treatment of restenosis. Encyclopedic Handbook of Biomaterials and Bioengineering. Wise DL. (eds.). Marcel Dekker, NY, Oct 1999.

1995

Golomb G, Moscovitz D, Fishbein I, Mishaly D.: Perivascular polymeric controlled-release therapy. Encyclopedic Handbook of Biomaterials and Bioengineering. Wise DL.  (eds.). Marcel Dekker, NY, Page: 1043-1055, Nov 1995.