Carolyn A. Felix, MD
Areas of expertise: Leukemia as a complication of anticancer treatment, Leukemia in infants, Molecular pathogenesis of childhood leukemia
Locations: Main Building
About Carolyn A. Felix, MD
Titles
Attending Physician
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Certifications
Hematology – American Board of Internal Medicine
Pediatrics – American Board of Pediatrics
Awards and Honors
2012, Joshua Kahan Endowed Chair in Pediatric Leukemia
2007, America's Top Doctors For Cancer
2006, Eagles Fly for Leukemia Award for Excellence in Treatment of Pediatric Cancer Patients
2006, Association of American Physicians (Elected Member)
2005-2006, 2009-2012, Philadelphia Magazine Top Doctors
2003, Society for Pediatric Research (Elected Member)
2001, Stohlman Scholar Award, Leukemia & Lymphoma Society
2000, Honorary Master of Arts Degree, University of Pennsylvania
2000, Eastern Pennsylvania Chapter Leukemia & Lymphoma Society Distinguished Leadership Award
1999, Klaus and Mary Hummeler Endowed Research Prize, The Children's Hospital of Philadelphia
1999, Eastern Pennsylvania Chapter Leukemia Society of America Distinguished Leadership Award
1992, American Society of Clinical Oncology Young Investigator Award
1991, American Association for Cancer Research Travel Award
1990, American Society of Pediatric Hematology-Oncology Young Investigator Award
1988, American Society of Hematology Travel Award
1987, American Society of Clinical Oncology Young Investigator in Training Travel Award
1977, Alpha Sigma Nu
1977, Alpha Epsilon Delta
1976, Phi Beta Kappa-junior year induction
1977, Graduated summa cum laude - Boston College, Chestnut Hill, MA
1973-1977, Boston College Honors Program
Leadership and Memberships
Memberships in Professional Organizations
2006-present, Association of American Physicians
2003-present, Society for Pediatric Research
2000-present, Children’s Oncology Group
1999-present, American Association for the Advancement of Science
1994-present, American Society of Hematology
1992-present, American Society of Clinical Oncology
1991-present, American Association for Cancer Research
1988-present, American Society of Pediatric Hematology-Oncology
Major Teaching and Clinical Responsibilities at the University of Pennsylvania
2022, External Examiner for PhD Thesis Committee of Grace Egan, MD, FRCP, Laboratory of Aaron D. Schimmer, MD, PhD, FRCPC, The Hospital for Sick Children and Princess Margaret Cancer Centre, University of Toronto
Editorial and Academic Positions
Editorial Positions
2013-present, Blood, editorial board
2004-2014, Pediatric Blood & Cancer, editorial board
Ad Hoc Reviewer for Journals
American Journal of Hematology
American Journal of Human Genetics
Biochemistry
Blood
British Journal of Cancer
British Journal of Haematology
Cancer
Cancer Genetics and Cytogenetics
Cancer Letters
Cancer Research
Clinical Cancer Research
Clinical and Diagnostic Laboratory Immunology
Genes, Chromosomes and Cancer
International Journal of Pediatric Hematology/Oncology
Journal of Clinical Investigation
Journal of Clinical Oncology
Journal of the National Cancer Institute
Journal of Pediatrics
Leukemia
Molecular Diagnosis
New England Journal of Medicine
Oncogene
Pediatric Blood & Cancer
Proceedings of the National Academy of Sciences
The American Journal of Human Genetics
The Journal of Pediatric Hematology-Oncology
European Journal of Hematology
Ad Hoc Reviewer for Grants
Leukemia & Lymphoma Society, Academic Clinical Trials Program Peer Review Committee
Academic and Institutional Committees
2011-2014, Hearings List for the Faculty Grievance Commission
2004-present, Research Affinity Group (RAG) Council, Joseph Stokes, Jr. Research Institute
2003-present, Normal and Malignant Hematopoiesis Research Affinity Group Leader
1999-present, University of Pennsylvania School of Medicine Combined Degree Admissions/Advisory Committee
1998, Founding Member, Center for Cancer Pharmacology, University of Pennsylvania Cancer Center
Education & training
Medical Degree
MD - Boston University School of Medicine, Boston, MA
Internship
Pediatrics - Children's Hospital of Pittsburgh, PA
Residency
Pediatrics - Children's Hospital of Pittsburgh, PA
Fellowship
Medical Staff Fellow - National Cancer Institute, Pediatric Branch, NIH, Bethesda, MD
Biotechnology Fellow - Pediatric Branch, National Cancer Institute, Bethesda, MD
Publications
Publications
2023
Robinson BW, Kairalla JA, Devidas M, Carroll AJ, Harvey RC, Heerema NA, Willman CL, Ball AR, Woods EC, Ballantyne NC, Urtishak KA, Behm FG, Reaman GH, Hilden JM, Camitta BM, Winick NJ, Pullen J, Carroll WL, Hunger SP, Dreyer ZE, Felix CA. KMT2A partner genes in infant acute lymphoblastic leukemia have prognostic significance and correlate with age, white blood cell count, sex, and central nervous system involvement: a Children's Oncology Group P9407 trial study. Haematologica. 2023 Mar 2. Epub 2023/03/03. doi:10.3324/haematol.2022.281552. PMID 36861410.
2022
Felix, CA, Slater, DJ, Davenport, JW, Yu, X, Gregory, BD, Li, MM, Rappaport, EF, Cheung, NV. KMT2A-MAML2 Rearrangement Emerged and Regressed During Neuroblastoma Therapy without Leukemia after 12.8-Year Follow-Up. Pediatr Blood Cancer. Jan 2022; 69(1): e29344. http://dx.doi.org/10.1002/pbc.29344.
Germano, G, Porazzi, P, Felix, CA. Leukemia-Associated Transcription Factor Mllt3 Is Important for Primitive Erythroid Development in Zebrafish Embryogenesis. Dev Dyn (Apr 16 2022). http://dx.doi.org/10.1002/dvdy.477.
2021
Chen, C, Yu, W, Alikarami, F, Qiu, Q, Chen, CH, Flournoy, J, Gao, P, Uzun, Y, Fang, L, Davenport, JW, Hu, Y, Zhu, Q, Wang, K, Libbrecht, C, Felmeister, A, Rozich, I, Ding, YY, Hunger, SP, Felix, CA, Wu, H, Brown, PA, Guest, EM, Barrett, DM, Bernt, KM, Tan, K. Single-cell multiomics reveals increased plasticity, resistant populations and stem-cell-like blasts in KMT2A-rearranged leukemia. Blood. 2021 Dec 5. pii: 482898. doi: 10.1182/blood.2021013442. PMID: 34864916
2018
Urtishak KA, Wang LS, Culjkovic-Kraljacic B, Davenport JW, Porazzi P, Vincent TL, Teachey DT, Tasian SK, Moore JS, Seif AE, Jin S, Barrett JS, Robinson BW, Chen IL, Harvey RC, Carroll MP, Carroll AJ, Heerema NA, Devidas M, Dreyer ZE, Hilden JM, Hunger SP, Willman CL, Borden KLB, Felix CA. Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia. Oncogene. 2019;38(13):2241-2262.Epub 2018 Nov 26. PMID: 30478448.
2017
Yu, X., Davenport, J.W., Urtishak, K.A. Carillo, M.L., Gosai, S.J., Kolaris, C.P., Byl, J.A.W., Rappaport, E.F., Osheroff, N., Gregory, B.D.*, Felix, C.A.* (*Co-corresponding). Genome-Wide TOP2A DNA Cleavage is Biased Towards Translocated and Highly Transcribed Loci. Genome Res. 27 (7) 1238-1249; 2017; Accession Number 28385713; doi 10.1101/gr.211615.116; PMC5495075.
2016
Urtishak, K. A., Robinson, B. W., Rappaport, E. F., Sarezky, M. D., Biegel, J. A., Nichols, K. E., Wilmoth, D. M., Wang, L. S., Stern, J. W., Felix, C. A. Unique Familial MLL(KMT2A)-Rearranged Precursor B Cell Infant Acute Lymphoblastic Leukemia (ALL) in Non-twin Siblings. Pediatr Blood Cancer [Epub 2016 March 21. doi: 10.1002/pbc.25957] Accession Number 26999444.