Katherine J. Deans, MD, MHSc
Areas of expertise: Thoracic Surgery, Neonatal Surgery, Clinical outcomes research
Locations: Main Building
About Katherine J. Deans, MD, MHSc
Titles
Attending surgeon
Assistant Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania
Certifications
Pediatric Surgery – American Board of Surgery
General Surgery – American Board of Surgery
Surgical Critical Care – American Board of Surgery
Research Interests
Ongoing Research Protocols
Co-Investigator; Children’s Hospital of Philadelphia Human Research Protocol IRB #2007-10-5512: Characterization of the levels and effects of intravascular hemolysis in patients undergoing cardiopulmonary bypass.
Co-Investigator; Children’s Hospital of Philadelphia Human Research Protocol IRB #2007-8-5451: Characterization of the levels and effects of intravascular hemolysis in patients undergoing extracorporeal membrane oxygenation.
Co-Investigator; University of Pennsylvania Human Research Protocol IRB #806867: Characterization of the levels and effects of intravascular hemolysis in patients undergoing cardiopulmonary bypass.
Co-Investigator; National Institutes of Health Animal Protocol ASP#CCM04-XX: The effect of glucocorticoids in a sedated and ventilated model of canine sepsis.
Education & training
Undergraduate Degree
BA, Political Science, Wellesley College, Wellesley, MA
Graduate Degree
MHSc, Clinical Research, Duke University, Durham, NC
Medical Degree
MD, Dartmouth Medical School, Hanover, NH
Internship
General Surgery, Massachusetts General Hospital, Boston, MA
Residency
General Surgery, Massachusetts General Hospital, Boston, MA
Fellowship
Critical Care Fellow, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD
Senior Research Fellow, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD
Research Fellow, Department of Surgery, Ma
Publications
Publications
2010
Deans KJ, Minneci PC, Klein HG, Natanson C. The relevance of practice misalignments to trials in transfusion medicine. Vox Sang. 2010 Jul 1;99(1):16-23. Epub 2010 Mar 21.
Deans KJ, Minneci PC. ACP Journal Club. Intensive insulin therapy did not reduce mortality more than conventional therapy in septic shock treated with corticosteroids. Ann Intern Med. 2010.
Deans KJ, Minneci PC, Klein HG, Natanson C. The relevance of practice misalignments to trials in transfusion medicine. Vox Sang. 2010.
Deans KJ, Minneci PC, Danner RL, Eichacker PQ, Natanson C. Practice Misalignments in Randomized Controlled Trials: Identification, Impact and Potential Solutions. Anesth Anal. 2010.
2009
Minneci PC, Deans KJ, Natanson C. Corticosteroid therapy for severe sepsis and septic shock. JAMA. 2009;302(15):643.
Deans KJ, Minneci PC, Chen H, Kern SJ, Logun C, Alsaaty S, Norsworthy KJ, Theel SM, Sennesh JD, Barb JJ, Munson PJ, Danner RL, Solomon MA. Impact of Animal Strain on Gene Expression in a Rat Model of Acute Cardiac Rejection. BMC Genomics 2009;10:280.
Minneci PC, Deans KJ, Eichacker PQ, Natanson C. The Effects of Steroids during Sepsis Depend on Dose and Severity of Illness: An Updated Meta-analysis. Clin Microbiol Infect.. 2009; 15(4):308-18.
Solomon SB, Minneci PC, Deans KJ, et al. Effects of Intra-aortic Balloon Counterpulsation in a Model of Septic Shock. Crit Care Med 2009;37:7-18.
2008
Deans KJ, Minneci PC, Shiva S, Zhi H, Banks SM, Kearns S, Natanson C, Solomon SB, Gladwin MT. Nitrite Reductase Activity of Hemoglobin: A systemic nitric oxide delivery mechanism to detoxify cell free plasma hemoglobin? Am J Physiol Heart Circ Physiol.2008;295:H743-754.
Minneci PC, Eichacker PQ, Danner RL, Banks SM, Natanson C, Deans KJ. The Importance of Usual Care Control Groups for Safety Monitoring and Validity during Critical Care Research. Intensive Care Med. 2008;34:942-947.
2007
Deans KJ, Minneci PC, Suffredini AF, et al. Randomization in Clinical Trials of Titrated Therapies: Unintended Consequences of Using Fixed Treatment Protocols. Crit Care Med. 2007; 2007;35(6):1509-1516.
Minneci PC, Deans KJ, Banks SM, et al. A Canine Model of Septic Shock: Balancing Animal Welfare and Scientific Relevance. Am J Physiol Heart Circ Physiol. 2007;293(4):H2487-500.
2006
Minneci PC, Deans KJ, Xizhong C, Banks SM, Natanson C, Eichacker PQ. Antithrombotic Therapies for Sepsis: A Need for More Studies. Crit Care Med. 2006;34(2)538-541.
Deans KJ, Minneci PC, Banks SM, Xizhong C, Natanson C, Eichacker PQ. Mechanical Ventilation in ARDS. Crit Care Med. 2006;34(1):263-267.
Books
Minneci PC, Deans KJ, Natanson C. Applying the Results of Randomized Controlled Trials: Caveat Emptor. In: Chiche JD, Moreno R, Putensen C, Rhodes A, eds. Patient Safety and Quality of Care in Intensive Care Medicine. Berlin: MWV Medizinisch Wissenschaftliche. 2010.
Deans, KJ. Gastrointestinal Bleeding. In: Mattei P, ed. Fundamentals of Pediatric Surgery. New York: Springer. 2010.
Deans KJ, Minneci PC, Cui X, Banks SM, Natanson C, Eichacker PQ. The Need to Account for Existing Practice Patterns in Trials of Mechanical Ventilation. In: Tobin MJ, eds. Principles and Practice of Mechanical Ventilation,. 2nd edition. New York: McGraw Hill. 2006:1347-1354.
Minneci PC, Deans KJ, Banks SM, Natanson C, Eichacker PQ. A Critical Review of Randomized Controlled Trials of Tidal Volume Reduction During ARDS. In: Dreyfuss D, Hubmayr RD, Saumon G, eds. Ventilator Induced Lung Injury. New York: Marcel Dekker, Inc.; 2006:519-536.
Minneci PC, Deans KJ, Haley M, Xizhong C, Natanson C, Eichacker PQ. Factors Influencing the Efficacy of Mediator-Specific Anti-inflammatory, Glucocorticoid and Anti-Coagulant Therapies for Sepsis. In: Gad SC, ed. Drug Discovery Handbook. Vol 1. Hoboken: Wiley Interscience; 2005:937-960.
Deans K, Minneci P, Eichacker PQ, Natanson C. Anti-Inflammatory Agents: A Double Edged Sword in Our Arsenal Against Septic Shock. In: Net A, ed. Shock and Multiorgan Failure. 2003 ed. Iberica: Springer-Verlag; 2003:pp.