Stephanie Brosius, MD, PhD
Locations: Main Building, Buerger Center for Advanced Pediatric Care
About Stephanie Brosius, MD, PhD
Titles
Attending Physician
Instructor, Perelman School of Medicine at the University of Pennsylvania
Awards and Honors
2021, Second Place Clinical Research NF Young Investigators’ Forum
2021, Meg Olivia Barkman Award for Clinical Excellence and Compassionate Care, Children’s Hospital of Philadelphia
2014, Samuel B. Barker Award for Excellence in Graduate Studies, University of Alabama at Birmingham
2013, Best Poster, Simpson-Ramsey Neurodevelopment Symposium, University of Alabama at Birmingham
2013, Best Neuroscience Poster, Medical Student Research Day, University of Alabama at Birmingham
2013, Second Place Data Presentation, Comprehensive Neuroscience Center Retreat, University of Alabama at Birmingham
2013, James M. Pittman Award for Commitment to Scholarship, University of Alabama at Birmingham
2013, Ralph D. Lillie Award for Outstanding Research Presentation in Pathology and Histochemistry, Experimental Biology, Boston, MA
2011, Best Neuroscience Poster, Medical Student Research Day, University of Alabama at Birmingham
2012, Commendation for Top 10% of the Class for Introduction to Clinical Medicine
2009, Graduation Magna Cum Laude, Washington University in St. Louis
2005-2009, Florence Moog Scholar in Biology and Chemistry, Washington University in St. Louis
2008, Amgen Scholar Research Award, California Institute of Technology, Pasadena, CA
2006.Jesse Stoakes Research Award, Midwest Cardiovascular Research Foundation, Bettendorf, IA
Leadership and Memberships
Memberships in Professional Organizations
2021-present, Society for Neuro-oncology
2021, Children’s Oncology Group
2020-present, Child Neurology Society
2009-present, American Association for the Advancement of Science
2018-present, American Association for the Advancement of Science
2007-present, Alpha Chi Sigma
Education & training
Graduate Degree
PhD in Neuroscience - University of Alabama at Birmingham, Birmingham, AL
Medical Degree
MD - University of Alabama School of Medicine, Birmingham, AL
Internship
Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA
Residency
Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA
Child Neurology - Children’s Hospital of Philadelphia, Philadelphia, PA (Chief Resident)
Fellowship
Neuro-oncology - Children’s Hospital of Philadelphia, Philadelphia, PA
Post-doctoral Fellow in Neuro-oncology - Children’s Hospital of Philadelphia, Philadelphia, PA
Publications
Publications
2022
Longo, J.F., Brosius SN, Carroll SL. Defining Gene Functions in Tumorigenesis In Vivo and In Vitro by Ex Vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells. JoVE 2022.
Brosius, S.N., Vossough A., Fisher M.J., Lang S.S., Beslow L.A., George B.J., Ichord R.N. Characteristics of Moyamoya Syndrome in Pediatric Patients With Neurofibromatosis Type 1. Pediatr Neurol 134: 1-8, 2022.
2021
Longo, J.F., Brosius SN, Znoyko I, Alers VA, Jenkins DP, Wilson RC, Carroll AJ, Wolff DJ, Roth KA, Carroll SL. Establishment and characterization of a sporadic malignant peripheral nerve sheath tumor. Sci Rep 11: 5690. 2021.
Weber, S.M., Brossier, N.M, Prechtl, A, Barnes, S, Wilson L.S., Brosius, S.N., Longo, J.F., and Carroll, S.L.R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. Cell Commun Signal 19 (1):95. 2021
2019
Longo, J.F*., Brosius, S.N.*, Black, L., Worley, S.H. Wilson, R.C., Roth, K.A., Carroll, S.L. ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent Mechanisms. Cell Commun Signal 74. 2019. * Denotes equal contributions to article
2016
Li, K, Turner, A.N., Chen, M, Brosius, S.N., Schoeb, T.R., Messiaen, L.M., Bedwell, D.M., Zinn, K.R., Anastasaki, C., Gutmann, D.H., Korf, B.R., Kesterson, R.A. Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type 1. Dis Model Mech 9:759-67. 2016.
2015
Brosius, S.N., Gonzalez, C.L., Shuresh, J, Walker, H.C. Reversible improvement in severe freezing of gait from Parkinson’s disease with unilateral interleaved deep brain stimulation. Parkinsonism Relat Disord. 21:1469-70, 2015.
Brossier, N.M., Prechtl, A.M., Longo, J.F., Barnes, S., Wilson, L.S., Byer, S.J., Brosius, S.N., and Carroll, S.L. Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells. Journal of Neuropathology and Experimental Neurology. 74: 568-586, 2015.
2014
Brosius, S.N., Turk, A.N., Byer, S.J., Brossier, N.M., Kohli, L., Roth, K.A., and Carroll, S.L. Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo MPNST pathogenesis. Acta Neuropathologica 127:573-591, 2014.
Brosius, S.N., Turk, A.N., Byer, S.J., Longo, J.F., Kappes, J.C., Carroll, A.J., Zinn, K.R., Roth, K.A., and Carroll, S.L. Combinatorial therapy with tamoxifen and trifluoperazine inhibits malignant peripheral nerve sheath tumor growth by targeting complementary signaling cascades. Journal of Neuropathology and Experimental Neurology. 73: 1079-1090, 2014.
2010
Brosius, S.N.: Neurognostics Question, Metamorphosis of a man: diagnosing Joseph Merrick. Proteus syndrome: Journal of the History of the Neurosciences 19: 171-172, 207-208, 2010.
Brosius, S.N.: A history of von Recklinghausen’s NF1. Journal of the History of the Neurosciences. 19: 333- 348, 2010.
2008
Shammas, N.W., Dipple, E.J., Shammas, G.A., Farland, L., Brosius, S.N., Jerin, M., Avila, A., Gehbauer, L., Winter, M., Stoakes, P., Byrd, J., Sharis, P., Robken, J. Intermediate term outcomes with bifurcation coronary stenting using the paclitaxel drug-eluting stent: a single centre experience. International Journal of Angiology 17:88-92, 2008.
2007
Shammas, N.W., Dippel, E.J., Avila, A., Gehbauer, L, Farland, L., Brosius, S.N., Jerin, M., Winter, M., Stoakes, P., Byrd, J., Majetic, L., Shammas, G., Sharis, P., Robken, J. Long-Term Outcomes in Treating Left Main Trifurcation Coronary Artery Disease with the Paclitaxel-Eluting Stent. Journal of Invasive Cardiology. 19: 77-82, 2007.
Editorials, Reviews, Chapters
2022
Brosius, S.N. and Taub, K. Neurocuteaneous Disorders. Netter’s Pediatrics Edition II. Elselvier 2022.
Brosius, S.N., Desai, K.A., and Shaw, A.C. Brain Tumors. Netter’s Pediatrics Edition II. Elselvier 2022.