Alyssa Baccarella, MD, MS
Areas of expertise: Gastroenterology, Inflammatory bowel disease (IBD)
Locations: Main Building
About Alyssa Baccarella, MD, MS
Titles
Attending Physician
Certifications
Pediatrics – American Board of Pediatrics
Awards and Honors
2023, 1st Place – Komarov Research Competition
2022-present, T32 NRSA Grant Awardee
2012, CHOP GI Fellowship Citizenship Award
2015, Alameda Contra Costa County Medical Association Summer Scholarship
2014, UCSF Pathways Explore Grant
2011, Walle J. H. Nauta Award for Outstanding Research
Leadership and Memberships
Memberships in Professional Organizations
2021-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
2021-present, American Gastroenterology Association
Education & training
Graduate Degree
MS in Health and Medical Sciences, Focus: Bioinformatics, University of California, Berkeley, CA
Medical Degree
MD - University of California, San Francisco, CA
Internship
Pediatrics - Presbyterian Morgan Stanley Children’s Hospital, Columbia University Medical Center, New York, NY
Residency
Pediatrics - New York- Presbyterian Morgan Stanley Children’s Hospital, Columbia University Medical Center, New York, NY
Fellowship
Pediatric Gastroenterology, Hepatology and Nutrition - Children’s Hospital of Philadelphia, Philadelphia, PA
Publications
Publications
2023
Kornberg A, Botella T, Moon CS, Rao S, Gelbs J, Cheng L, Miller J, Baccarella AM, García- Vilas JA, Vargas J, Yu X, Krupska I, Bush E, Garcia-Carrasquillo R, Lebwohl B, Krishnareddy S, Lewis S, Green PHR, Bhagat G, Yan KS, Han A. Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease. Sci Immunol. 2023 Jul 21;8(85):eadf4312. doi: 10.1126/sciimmunol.adf4312. Epub 2023 Jul 14. PMID: 37450575; PMCID: PMC10481382.
Baccarella, A., Lee, C., Bass, R., & Quinn, S. (2023). A 12-Year-Old Girl with Weight Loss. NEJM Evidence, 2(2), EVIDmr2200308.
2022
Shaul E, Conrad MA, Dawany N, Patel T, Canavan MC, Baccarella A, Weinbrom S, Aleynick D, Sullivan KE, Kelsen JR. Canakinumab for the treatment of autoinflammatory very early onset- inflammatory bowel disease. Front Immunol. 2022 Sep 20;13:972114. doi: 10.3389/fimmu.2022.972114. PMID: 36203564; PMCID: PMC9531243.
Masuda K, Kornberg A, Miller J, Lin S, Suek N, Botella T, Secener KA, Baccarella AM, Cheng L, Ingham M, Rosario V, Al-Mazrou AM, Lee-Kong SA, Kiran RP, Stoeckius M, Smibert P, Del Portillo A, Oberstein PE, Sims PA, Yan KS, Han A. Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer. JCI Insight. 2022 Apr 8;7(7):e154646. doi: 10.1172/jci.insight.154646. PMID: 35192548; PMCID: PMC9057629.
Aschbacher, K., Cole, S., Hagan, M., Rivera, L., Baccarella, A., Wolkowitz, O.M., Lieberman, A.F., and Bush, N.R. (2022). An immunogenomic phenotype predicting behavioral treatment response: Toward precision psychiatry for mothers and children with trauma exposure. Brain. Behav. Immun. 99, 350–362.
2021
Aschbacher, K., Hagan, M., Steine, I.M., Rivera, L., Cole, S., Baccarella, A., Epel, E.S., Lieberman, A., and Bush, N.R. (2021). Adversity in early life and pregnancy are immunologically distinct from total life adversity: macrophage-associated phenotypes in women exposed to interpersonal violence. Transl. Psychiatry 2021 111 11, 1–9. Available at: https://www.nature.com/articles/s41398-021-01498-1 [Accessed February 12, 2022].
Baccarella, A., Linder, A., Spencer, R., Jonokuchi, A.J., King, P.B., Maldonado-Soto, A., Boneparth, A., Hooe, B.S., Schweickert, A.J., Carlin, R.F., et al. (2021). Increased Intracranial Pressure in the Setting of Multisystem Inflammatory Syndrome in Children, Associated With COVID-19. Pediatr. Neurol. 115, 48–49. Available at: http://www.pedneur.com/article/S0887899420303647/fulltext [Accessed February 12, 2022].
2020
Kim, C.C., Baccarella, A.M., Bayat, A., Pepper, M., and Fontana, M.F. (2019). FCRL5+ Memory B Cells Exhibit Robust Recall Responses. Cell Rep. 27, 1446. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530801/ [Accessed June 12, 2020].
Baccarella, A., Williams, C.R., Parrish, J.Z., and Kim, C.C. (2018). Empirical assessment of the impact of sample number and read depth on RNA-Seq analysis workflow performance. BMC Bioinformatics 19. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234607/ [Accessed June 12, 2020].
2017
Williams, C.R. ϯ, Baccarella, A. ϯ, Parrish, J.Z., and Kim, C.C. (2017). Empirical assessment of analysis workflows for differential expression analysis of human samples using RNA-Seq. BMC Bioinformatics 18, 38. Available at: http://www.ncbi.nlm.nih.gov/pubmed/28095772 [Accessed April 27, 2017].
2016
Fontana, M.F., Baccarella, A., Craft, J.F., Boyle, M.J., McIntyre, T.I., Wood, M.D., Thorn, K.S., Anidi, C., Bayat, A., Chung, M.R., et al. (2016). A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection. PLoS One 11, e0162132. Available at: http://www.ncbi.nlm.nih.gov/pubmed/27583554 [Accessed April 27, 2017].
Williams, C.R., Baccarella, A., Parrish, J.Z., and Kim, C.C. (2016). Trimming of sequence reads alters RNA-Seq gene expression estimates. BMC Bioinformatics 17, 103. Available at: http://www.ncbi.nlm.nih.gov/pubmed/26911985 [Accessed July 7, 2016].
2015
Fontana, M.F., Baccarella, A., Kellar, D., Oniskey, T.K., Terinate, P., Rosenberg, S.D., Huang, E.J., Herbert, D.R., and Kim, C.C. (2015). Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections. Parasite Immunol. 37, 470–8. Available at: http://www.ncbi.nlm.nih.gov/pubmed/26178310 [Accessed July 7, 2016].
Fontana, M.F., Baccarella, A., Pancholi, N., Pufall, M.A., Herbert, D.R., and Kim, C.C. (2015). JUNB is a key transcriptional modulator of macrophage activation. J. Immunol. 194, 177–86. Available at: http://www.ncbi.nlm.nih.gov/pubmed/25472994 [Accessed July 7, 2016].
2014
Baccarella, A., Huang, B.W., Fontana, M.F., and Kim, C.C. (2014). Loss of Toll-like receptor 7 alters cytokine production and protects against experimental cerebral malaria. Malar. J. 13, 354. Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4164820&tool=pmcentrez&rendertype=abstract [Accessed February 24, 2015].
2013
Baccarella, A. ϯ, Fontana, M.F. ϯ, Chen, E.C., and Kim, C.C. (2013). Toll-like receptor 7 mediates early innate immune responses to malaria. Infect. Immun. 81, 4431–4442.
Soda, T., Frank, C., Ishizuka, K., Baccarella, A., Park, Y.-U., Flood, Z., Park, S.K., Sawa, A., and Tsai, L.-H. (2013). DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1. Mol. Psychiatry 18, 898–908. Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3730299&tool=pmcentrez&rendertype=abstract.
Abstracts (includes Posters and Scientific Presentations)
2023
Baccarella, A. Patel, T., Boyer B., Dawany, N., Heimall, J., Bunin, N., Sullivan, KE., Conrad, MA., Kelsen, JR. “Single Center Retrospective Analysis of Hematopoietic Stem Cell Transplant In Patients with Monogenic Inflammatory Bowel Disease”, Digestive Disease Week, Chicago, IL, May 2023.
A. Baccarella, Pickering, O., Patel, T., Boyer B., Dawany, N., Heimall, J., Bunin, N., Sullivan, KE., Conrad, MA., Kelsen, JR. “Single Center Retrospective Analysis of Hematopoietic Stem Cell Transplant In Patients with Monogenic Inflammatory Bowel Disease”, Accepted for NASPGHAN 2023 Annual Meeting, San Diego, CA, October 2023.
Lectures by Invitation
2023
A. Baccarella. “Morning Report: A 12-Year-Old Girl with Weight Loss” Twitter Spaces. Invited Discussant hosted by NEJM Evidence. February 2023.
Editorials, Reviews, Chapters
Baccarella, A, Kelsen, J. Gastrointestinal Disorders Associated with Immunodeficiency. Rudolph’s Pediatrics, 24e. McGraw Hill in press