Ivan S. Alferiev, PhD

2020

Inamdar Vaishali V, Fitzpatrick Emmett, Alferiev Ivan, Nagaswami Chandrasekaran, Spruce Lynn A, Fazelinia Hossein, Bratinov George, Seeholzer Steven H, Levy Robert J, Fishbein Ilia, Stachelek Stanley J: Stability and bioactivity of pepCD47 attachment on stainless steel surfaces. Acta Biomaterialia 104: 231-240, Mar 2020.

Zhang Q, Stachelek SJ, Inamdar VV, Alferiev I, Nagaswami C, Weisel JW, Hwang JH, Meyerhoff ME.: Studies of combined NO-eluting/CD47-modified polyurethane surfaces for synergistic enhancement of biocompatibility. Colloids Surf B Biointerfaces. 192: 111060, Apr 2020.

William P. Shield III, Ashley Cellini, Hongying Tian, Kim Wilson, Yang Dan, Joshua M. Abzug, Sonia Garcia, Norifumi Moritani, Ivan Alferiev, Michael Chorny, Masaharu Takigawa, Vincent Y. Ng, Masahiro Iwamoto, Motomi Enomoto‐Iwamoto : Selective Agonists of Nuclear Retinoic Acid Receptor Gamma Inhibit Growth of HCS‐2/8 Chondrosarcoma Cells  Journal of Orthopaedic Research 38: 1045-1051, May 2020.

Nguyen F, Guan P, Guerrero DT, Kolla V, Naraparaju K, Perry LM, Soberman D, Pressly BB, Alferiev IS, Chorny M, Brodeur GM.: Structural Optimization and Enhanced Prodrug-Mediated Delivery Overcomes Camptothecin Resistance in High-Risk Solid Tumors. Cancer Res. 80(19): 4258-4265, Oct 2020 Notes: co-Senior Author.

Battig MR, Alferiev IS, Guerrero DT, Fishbein I, Pressly BB, Levy RJ, Chorny M: An Experiental Single-Platform Approach to Enhance Functionalization of Magnetically Targetable Cells ACS Applied Bio Materials; 2020 Notes: accepted for publication; mt-2020-00466a.R1; DOI: 10.1021/acsabm.0c00466; NIHMS1597029.

2018

Nguyen F, Alferiev I, Guan P, Guerrero DT, Kolla V, Moorthy GS, Chorny M, Brodeur GM.: Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model. Clinical Cancer Research 24(11): 2585-2593, June 2018.

Battig Mark R, Fishbein Ilia, Levy Robert J, Alferiev Ivan S, Guerrero David, Chorny Michael: Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system. Drug delivery and translational research 8(4): 954-963, Aug 2018.

2017

I. Fishbein, D. Guerrero, I. Alferiev, J. Foster, N. Minutolo, M. Chorny, A. Mas Monteys, K. Driesbaugh, Ch. Nagaswami, RJ. Levy. : Stent-based delivery of adeno-associated viral vectors with sustained vascular transduction and iNOS-mediated inhibition of in-stent restenosis. Gene Therapy 24(11): 717-726, Nov 2017.

2016

Adamo Richard F, Fishbein Ilia, Zhang Kehan, Wen Justin, Levy Robert J, Alferiev Ivan S, Chorny Michael: Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries. Journal of controlled release : official journal of the Controlled Release Society 222(1): 169-75, Jan 2016.

Slee Joshua B, Alferiev Ivan S, Nagaswami Chandrasekaran, Weisel John W, Levy Robert J, Fishbein Ilia, Stachelek Stanley J: Enhanced biocompatibility of CD47-functionalized vascular stents. Biomaterials 87(1): 82-92, May 2016.

Fishbein I, WelchT ,Guerrero DT ,Alferiev IS ,Adamo RF , Chorny M, Gupte RK, Tang Y, Levy RJ: Paraffin Processing of Stented Arteries Using a Post-Fixation Dissolution of Metallic and Polymeric Stents. Cardiovascular Pathology 25(6): 483-488, Aug 2016.

2015

Iyer Radhika, Croucher Jamie L, Chorny Michael, Mangino Jennifer L, Alferiev Ivan S, Levy Robert J, Kolla Venkatadri, Brodeur Garrett M: Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma. Cancer letters 360(2): 205-12, Feb 2015.

Alferiev Ivan S, Iyer Radhika, Croucher Jamie L, Adamo Richard F, Zhang Kehan, Mangino Jennifer L, Kolla Venkatadri, Fishbein Ilia, Brodeur Garrett M, Levy Robert J, Chorny Michael: Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials 51(1): 22-9, May 2015.

Christian Abigail J, Alferiev Ivan S, Connolly Jeanne M, Ischiropoulos Harry, Levy Robert J: The effects of the covalent attachment of 3-(4-hydroxy-3,5-di-tert-butylphenyl) propyl amine to glutaraldehyde pretreated bovine pericardium on structural degeneration, oxidative modification, and calcification of rat subdermal implants. Journal of biomedical materials research. Part A 103(7): 2441-8, Jul 2015.

2014

Christian Abigail J, Lin Hongqiao, Alferiev Ivan S, Connolly Jeanne M, Ferrari Giovanni, Hazen Stanley L, Ischiropoulos Harry, Levy Robert J: The susceptibility of bioprosthetic heart valve leaflets to oxidation. Biomaterials 35(7): 2097-102, Feb 2014.

Tengood JE, Alferiev IS, Zhang K, Fishbein I, Levy RJ, Chorny M.: Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media. Proc Natl Acad Sci U S A 111(11): 4245-50, Mar  2014.

Hood Elizabeth D, Chorny Michael, Greineder Colin F, Alferiev Ivan, Levy Robert J, Muzykantov Vladimir R: Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation. Biomaterials 35(11): 3708-15, Apr 2014.

Howard Melissa D, Hood Elizabeth D, Greineder Colin F, Alferiev Ivan S, Chorny Michael, Muzykantov Vladimir: Targeting to endothelial cells augments the protective effect of novel dual bioactive antioxidant/anti-inflammatory nanoparticles. Molecular pharmaceutics 11(7): 2262-70, Jul 2014.

Fishbein Ilia, Forbes Scott P, Adamo Richard F, Chorny Michael, Levy Robert J, Alferiev Ivan S: Vascular gene transfer from metallic stent surfaces using adenoviral vectors tethered through hydrolysable cross-linkers. Journal of visualized experiments : JoVE 90(1): e51653, Aug 2014.

Slee JB, Alferiev IS, Levy RJ, Stachelek SJ: The use of the ex vivo Chandler Loop Apparatus to assess the biocompatibility of modified polymeric blood conduits. Journal of visualized experiments : JoVE  90(1): e51871, Oct 2014.

2013

Ma G, Wang Y, Fishbein I, Yu M, Zhang L, Alferiev IS, Yang J, Song C, Levy RJ.: Anchoring of self-assembled plasmid DNA/ anti-DNA antibody/cationic lipid micelles on bisphosphonate-modified stent for cardiovascular gene delivery. Int J Nanomedicine 8(1): 1029-1035, March 2013.

Chorny Michael, Fishbein Ilia, Tengood Jillian E, Adamo Richard F, Alferiev Ivan S, Levy Robert J: Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 27(6): 2198-206, Jun 2013.

Fishbein Ilia, Forbes Scott P, Chorny Michael, Connolly Jeanne M, Adamo Richard F, Corrales Ricardo A, Alferiev Ivan S, Levy Robert J: Adenoviral vector tethering to metal surfaces via hydrolyzable cross-linkers for the modulation of vector release and transduction. Biomaterials 34(28): 6938-48, Sep 2013.

Forbes Scott P, Alferiev Ivan S, Chorny Michael, Adamo Richard F, Levy Robert J, Fishbein Ilia: Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: implications for gene therapy of restenosis. Atherosclerosis 230(1): 23-32, Sep 2013.

Finley Matthew J, Clark Katherine A, Alferiev Ivan S, Levy Robert J, Stachelek Stanley J: Intracellular signaling mechanisms associated with CD47 modified surfaces. Biomaterials 34(34): 8640-9, Nov 2013.

2012

M Chorny, I Fishbein, RF Adamo, SP Forbes, Z Folchman-Wagner, IS Alferiev: Magnetically targeted delivery of therapeutic agents to injured blood vessels for prevention of in-stent restenosis. Methodist Debakey Cardiovascular J 8(1): 25-29, Jan 2012.

Chorny Michael, Alferiev Ivan S, Fishbein Ilia, Tengood Jillian E, Folchman-Wagner Zoë, Forbes Scott P, Levy Robert J: Formulation and in vitro characterization of composite biodegradable magnetic nanoparticles for magnetically guided cell delivery. Pharmaceutical research 29(5): 1232-41, May 2012.

Matthew J. Finley, Lubica Rauova, Ivan S. Alferiev, John W. Weisel, Robert J. Levy, Stanley J. Stachelek: Diminished adhesion and activation of platelets and neutrophils with CD47functionalized blood contacting surfaces. Biomaterials 33(24): 5803-5811, Aug 2012.

2011

Connolly Jeanne M, Bakay Marina A, Alferiev Ivan S, Gorman Robert C, Gorman Joseph H, Kruth Howard S, Ashworth Paul E, Kutty Jaishankar K, Schoen Frederick J, Bianco Richard W, Levy Robert J: Triglycidyl amine crosslinking combined with ethanol inhibits bioprosthetic heart valve calcification. The Annals of thoracic surgery 92(3): 858-65, Sep 2011.

Wang Yong, Yu Mei, Zhang Linhua, Song Cunxian, Alferiev Ivan S, Levy Robert J: Immobilization of gene vectors on bisphosphonate-mediated gene-eluting metal stents using antibody for localized gene delivery. Journal of controlled release : official journal of the Controlled Release Society 152 Suppl 1: e173-4, Nov 2011.

2010

Hunter Shawn A, Rapoport H Scott, Connolly Jeanne M, Alferiev Ivan, Fulmer James, Murti Brandon H, Herfat Mohammadsafa, Noyes Frank R, Butler David L, Levy Robert J: Biomechanical and biologic effects of meniscus stabilization using triglycidyl amine. Journal of biomedical materials research. Part A 93(1): 235-42, Apr 2010.

Chorny Michael, Fishbein Ilia, Yellen Benjamin B, Alferiev Ivan S, Bakay Marina, Ganta Srinivas, Adamo Richard, Amiji Mansoor, Friedman Gary, Levy Robert J: Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields. Proceedings of the National Academy of Sciences of the United States of America 107(18): 8346-51, May 2010.

Stachelek Stanley J, Alferiev Ivan, Ueda Masako, Eckels Edward C, Gleason Kevin T, Levy Robert J: Prevention of polyurethane oxidative degradation with phenolic antioxidants covalently attached to the hard segments: structure-function relationships. Journal of biomedical materials research. Part A 94(3): 751-9, Sep 2010.

Ueda Masako, Alferiev Ivan S, Simons Stacey B, Hebbel Robert P, Levy Robert J, Stachelek Stanley J: CD47-dependent molecular mechanisms of blood outgrowth endothelial cell attachment on cholesterol-modified polyurethane. Biomaterials 31(25): 6394-9, Sep 2010.

Uttayarat Pimpon, Perets Anat, Li Mengyan, Pimton Pimchanok, Stachelek Stanley J, Alferiev Ivan, Composto Russell J, Levy Robert J, Lelkes Peter I: Micropatterning of three-dimensional electrospun polyurethane vascular grafts. Acta biomaterialia 6(11): 4229-37, Nov 2010.

2009

Chorny Michael, Fishbein Ilia, Alferiev Ivan, Levy Robert J: Magnetically responsive biodegradable nanoparticles enhance adenoviral gene transfer in cultured smooth muscle and endothelial cells. Molecular pharmaceutics 6(5): 1380-7, Sep-Oct 2009.

2008

Polyak Boris, Fishbein Ilia, Chorny Michael, Alferiev Ivan, Williams Darryl, Yellen Ben, Friedman Gary, Levy Robert J: High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents. Proceedings of the National Academy of Sciences of the United States of America 105(2): 698-703, Jan 2008.

Fishbein Ilia, Alferiev Ivan, Bakay Marina, Stachelek Stanley J, Sobolewski Peter, Lai Meizan, Choi Hoon, Chen I-W, Levy Robert J: Local delivery of gene vectors from bare-metal stents by use of a biodegradable synthetic complex inhibits in-stent restenosis in rat carotid arteries. Circulation 117(16): 2096-103, Apr 2008.

2007

Rapoport H Scott, Connolly Jeanne M, Fulmer James, Dai Ning, Murti Brandon H, Gorman Robert C, Gorman Joseph H, Alferiev Ivan, Levy Robert J: Mechanisms of the in vivo inhibition of calcification of bioprosthetic porcine aortic valve cusps and aortic wall with triglycidylamine/mercapto bisphosphonate. Biomaterials 28(4): 690-9, Feb 2007.

Chorny Michael, Polyak Boris, Alferiev Ivan S, Walsh Kenneth, Friedman Gary, Levy Robert J: Magnetically driven plasmid DNA delivery with biodegradable polymeric nanoparticles. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21(10): 2510-9, Aug 2007.

2006

Alferiev IS, Connolly JM, Stachelek SJ, Ottey A, Rauova L, Levy RJ.: Surface heparinization of polyurethane via bromoalkylation of hard segment nitrogens. Biomacromolecules 7(1): 317-322, Jan 2006.

Fishbein I, Alferiev IS, Nyanguile O, Gaster R, Vohs JM, Wong GS, Felderman H, Chen IW, Choi H, Wilensky RL, Levy RJ.: Bisphosphonate-mediated gene vector delivery from the metal surfaces of stents. Proc Natl Acad Sci USA 103(1): 159-164, Jan 2006.

Stachelek SJ, Alferiev I, Connolly JM, Sacks M, Hebbel RP, Bianco R, Levy RJ.: Cholesterol-modified polyurethane valve cusps demonstrate blood outgrowth endothelial cell adhesion post-seeding in vitro and in vivo. Ann Thorac Surg 81(1): 47-55, Jan 2006.

Chorny M, Fishbein I, Alferiev IS, Nyanguile O, Gaster R, Levy RJ.: Adenoviral gene vector tethering to nanoparticle surfaces results in receptor-independent cell entry and increased transgene expression. Mol Ther 14(3): 382-91, Sep 2006.

Chorny Michael, Fishbein Ilia, Alferiev Ivan S, Nyanguile Origene, Gaster Richard, Levy Robert J: Adenoviral gene vector tethering to nanoparticle surfaces results in receptor-independent cell entry and increased transgene expression. Molecular therapy : the journal of the American Society of Gene Therapy 14(3): 382-91, Sep 2006.

Stachelek SJ, Alferiev I, Choi H, Ottey A, Levy RJ.: Prevention of oxidative degradation of polyurethane by covalent attachment of di-tert-butylphenol residues. J Biomed Mater Res A 78(4): 653-61, Sep 2006.

2005

Connolly JM, Alferiev I, Clark-Gruel JN, Eidelman N, Sacks M, Palmatory E, Kronsteiner A, Defelice S, Xu J, Ohri R, Narula N, Vyavahare N, Levy RJ.: Triglycidylamine crosslinking of porcine aortic valve cusps or bovine pericardium results in improved biocompatibility, biomechanics, and calcification resistance: chemical and biological mechanisms. Am J Pathol 166(1): 1-13, Jan 2005.

Stachelek SJ, Alferiev I, Choi H, Kronsteiner A, Uttayarat P, Gooch KJ, Composto RJ, Chen IW, Hebbel RP, Levy RJ.: Cholesterol-derivatized polyurethane: characterization and endothelial cell adhesion. J Biomed Mater Res A 72(2): 200-212, Feb 2005.

Alferiev IS, Connolly JM, Levy RJ.: A novel mercapto-bisphosphonate as an efficient anticalcification agent for bioprosthetic tissues. Journal of Organometallic Chemistry 690(10): 2543-2547, May 2005.

Fishbein I, Stachelek SJ, Connolly JM, Wilensky RL, Alferiev I, Levy RJ.: Site specific gene delivery in the cardiovascular system. J Control Release 109(1-3): 37-48, Dec 2005.

2004

Stachelek SJ, Song C, Alferiev I, Defelice S, Cui X, Connolly JM, Bianco RW, Levy RJ.: Localized gene delivery using antibody tethered adenovirus from polyurethane heart valve cusps and intra-aortic implants. Gene Ther 11(1): 15-24, Jan 2004.

Connolly JM, Alferiev I, Kronsteiner A, Lu Z, Levy RJ.: Ethanol inhibition of porcine bioprosthetic heart valve cusp calcification is enhanced by reduction with sodium borohydride. J Heart Valve Dis 13(3): 487-493, May 2004.

2003

I. Alferiev, S. J. Stachelek, Z. Lu, A. Fu, T. L. Sellaro, J. M. Connolly, R. W. Bianco, M. S. Sacks and R. J. Levy : Prevention of polyurethane valve cusp calcification with covalently attached bisphosphonate diethylamino moieties. J Biomed Mater Res A. 66A(2): 385-395, Aug 2003 Notes: (Joint first author).

Alferiev IS, Levy RJ.: Pharmacologically modified biomedical polyurethanes. PBM Series (Introduction to Biomaterials) 1: 137-155, 2003.

2002

Alferiev, I.S.: Novel elastomeric polyurethanes with pendant epoxy groups as highly reactive auxiliary groups for further derivatizations. Journal of Polmer Science: Part A: Polymer Chemistry 40: 4378-4385, Oct 2002.

Alferiev, I.S., Fishbein, I.: Activated polyurethane modified with latent thiol groups. Biomaterials 23(24): 4753-4758, Dec 2002.

2001

Alferiev, I.S., Hinson, J.T., Ogle, M., Breuer, E., Levy, R.J.: High reactivity of alkyl sulfides towards epoxides under conditions of collagen fixation - a convenient approach to 2-amino-4-butyrolactones. Biomaterials 22(18): 2501-2506, Sep 2001.

Alferiev, I.S., Vyavahare, N.R., Song, C.X., Connoly, J., Hinson J.T. Lu, Zh.B., Tallapragada, S., Bianco, R., Levy, R.J.: Bisphosphonate derivatized polyurethanes resist calcificaton. Biomaterials 22(19): 2683-2693, Oct 2001.

Alferiev, I.S., Vyavahare, N.R., Song, C.X., Levy, R.J.: Elastomeric polyurethanes modified with geminal bisphosphonate groups. Journal of Polymer Science: Part A: Polymer Chemistry 39(1): 105-116, 2001.

2000

Ezra, A., Hoffman, A., Breuer, E., Alferiev, I.S., Mönkönen, El Hanany-Rozen, N., Weiss, G., Stepinsky, D., Gati, I., Cohen, H., Törmälehto, Amidon, G.L., Golomb, G.: A peptide prodrug approach for improving bisphosphonate oral absorption. Journal of Medicinal Chemistry 43(20): 3641-3652, Oct 2000.

1999

Alferiev, I.S.: Cyclic oligophosphonic anhydrides in phosphonation of diacylamides. Phosphorus, Sulfur, and Silicon 147: 5, 1999.

Cohen, H., Alferiev, I.S., Mönkönen, Seibel, M.J., Pinto, T., Ezra, A., Solomon, V., Stepinsky, D., Sagi, H., Ornoy, A., Patlas, N., Hagele, G., Hoffman, A., Breuer, E., Golomb, G.: Synthesis and preclinical pharmacology of 2-(2-aminopyrimidinio) ethylidene-1, 1-bisphosphonic acid betaine (ISA-13-1) - a novel biphosphonate. Pharmaceutical Research 16(9): 1399-1406, 1999.

Martin, V.V., Alferiev, I.S., Weis, A.L.: Amplified fluorescent molecular probes based on 1,3,5,7-tetrasubstituted adamantane. Tetrahedron Letters 40(2): 223-226, 1999.

Weis, A.L., Bakos,T., Alferiev, I.S., Zhang, X., Shao, B., Kinney, W.A.: Synthesis of an azido spermidine equivalent. Tetrahedron Letters 40(26): 4863-4864, 1999.

1998

Cohen, H., Solomon, V., Alferiev, I.S., Breuer, E., Ornoy, A., Patlas, N., Eidelman, N., Hagele, G., Golomb, G.: Bisphosphonates and tetracycline: experimental models for their evaluations in calcium-related disorders. Pharmaceutical Research 15(4): 606-613, 1998.

Mathew, M., Fowler, B.O., Breuer, E., Golomb, G., Alferiev, I.S., Eidelman, N.: Sythesis, characterization and crystal structure of dicalcium glutarylbis(phosphonate) dihydrate: a covalently pillared layer structure with the potential for epitaxial growth on hydroxyapatite. Inorganic Chemistry 37(25): 6485-6494, 1998.

1996

Alferiev, I.S., Breuer, E.: Aldol-type cyclization of bisacyl-phosphonates. A unique concerted catalytic effect of diamines. Phosphorus, Sulfur and Silicon 111: 796, 1996.

Golomb, G., Van Gelder, J.M., Alferiev, I.S., Ornoy, A., Hoffman, A., Schlossman, A., Friedman-Ezra, N., El-Hanany-Rozen, N., Chen, R., Solomon, V., Cohen, H., Rabinovich, L., Breuer, E.: Novel bisphosphonates for calcium related disorders. Phosphorus, Sulfur and Silicon 109/110: 221-224, 1996.

Mikhalin, N.V., Alferiev, I.S.: Ion-exchange polymers with chelating 1, 1-diphosphonic acid groups. Vysokomolekulyarnye Soedineniya, Ser. A. Ser.B. 38(5): 905-907, 1996.

Mikhalin, N.V., Alferiev, I.S.  : Ion-exchange polymers with chelating 1, 1-diphosphonic acid groups.   Chemical Abstracts   125(1): 329683r, 1996.

Novikova, V.M., Mikhalin, I.S., Alferiev, I.S.: Significance of cAMP system activation in restoration of colony forming ability of red stem cells and life duration of lethally irradiated animals. Radiatsionnaya Biologiya, Radioekologiya 36(1): 30-35, 1996.

Novikova, V.M., Mikhalin, N.V., Alferiev, I.S., Kozlov, V.A.: Significance of cAMP system activation in restoration of colony forming ability of red stem cells and life duration of lethally irradiated animals. Chemical Abstracts 125(1): 162160d, 1996.

1995

Alferiev, I.S., Mikhalin, N.V.: Reactions of vinylidenediphosphonic acid with nucleophiles, Comm.5, Addition of heterocyclic amines and trimethylamine to vinylidenediphosphonic acid. Bulletin of the Russian Academy of Sciences, Division of Chemical Science 44(8): 1528-1530 (English Translation), 1995.

1994

Larionov, S.V., Myachina, L.I., Alferiev, I.S., Savelov, A.A., Sheludyakova, L.A.: Synthesis of manganese (2+), iron (2+), iron (3+) and gadolinium (3+) complexes with 3-amino-1-hydroxy-propylidene-1, 1-diphosphonic acid. Chemical Abstracts 120(1): 67835r, 1994.

1993

Larionov, S.V., Myachina, L.I., Alferiev, I.S., Savelov, A.A., Sheludyakova, L.A.: Synthesis of manganese (2+), iron (2+), Iron (3+) and gadolinium (3+) complexes with 3-amino-1-hydroxy-proppylidene-1, 1-diphosphonic acid. Sib.Khim.Zh. 2: 46-49, 1993.

1992

Alferiev, I.S., Bobkov, S.Yu: Cyclic oligophosphonic anhydrides. Mendeleev Communications 1: 12-13, 1992.

Alferiev, I.S., Bobkov, S.Yu.: Cyclic oligophosphonic anhydrides stable in aqueous media. Zeitschrift fur Naturforschung 47b: 1213-1224, 1992.

Alferiev, I.S., Mikhalin, N.V.: Reactions of vinylidenediphosphonic acid with nucleophiles, Comm.4, Addition of amino-acids, diastereotopy of phosphorus atoms in the addition products. Bulletin of the Russian Academy of Sciences, Division of Chemical Science 41(9): 1709-1711 (English Translation), 1992.

1988

Krainev, A.G., Weiner, L.M., Alferiev, I.S., Mikhalin, N.V.: Localization of the active center of microsomal cytochrome P-450. Biochemical and Biophysical Research Communications 150(1): 426-435, 1988.

1987

Alferiev, I.S., Bobkov, S. Yu., Kotlyarevskii, I.L.: 1-Alkoxy(aryloxy)-alkylidene-1, 1-diphosphonic acids. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science  36(3): 571-576 (English Translation), 1987.

Alferiev, I.S., Bobkov, S.Yu., Kotlyarevskii, I.L.: Reaction of pyrophosphites with carboxylate esters. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science 36(3): 577-579 (English Translation), 1987.

Alferiev, I.S., Bobkov, S.Yu., Kotlyarevskii, I.L.: Iminobis(methylene-diphosphonic) acid. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science 36(4): 791-794 (English Translation), 1987.

Alferiev, I.S., Mikhalin, N.V., Kotlyarevskii, I.L., Vainer, L.M.: Reactions of vinylidenediphosphonic acid with nucleophiles, Comm. 3, Addition of thiols. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science 36(4): 786-790 (English Translation), 1987.

1985

Krainev, A.G., Weiner, L.M., Alferiev, I.S., Slynko, N.M.: Bifunctional compounds for studying localization of the active center of cytochrome P-450 in a microsomal membrane ("float" molecules method). Biochimica et Biophysica Acta 818: 96-104, 1985.

1984

Alferiev, I.S., Kotlyarevskii, I.L., Mikhalin, N.V. : Addition of nucleophilic agents to vinyldenediphosphonic acid, Comm. 2, Reactions of vinylidenediphosphonic acid with primary amines, ammonia and hydrazine. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science 33(5): 1031-1035 (English Translation), 1984.

Alferiev, I.S., Vainer, L.M., Krainev, A.G., Slynko, N.M.: New bifunctional reagents for the study of cytochrome P-450 active center localization in microsomal membrane. Chemical Abstracts 101(1): 226040d, 1984.

Alferiev, I.S., Vainer, L.M., Krainev, A.G., Slynko, N.M.: New bifunctional reagents for the study of cytochrome P-450 active center localization in microsomal membrane. Doklady Akademii Nauk SSSR 277: 371-374, 1984.

1983

Alferiev, I.S., Kotlyarevskii, I.L., Mikhalin, N.V., Novikova, V.M.: Reactions of vinylidenediphosphonic acid with nucleophiles, Comm.1, Addition of aliphatic amines. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science 32(12): 2515-2518 (English Translation), 1983.

1980

Alferiev, I.S., Kotlyarevskii, I.L., Mikhalin, N.V., Novikova, V.M.: Nucleophilic addition of amines to vinylidenediphosphonic acid. Chemical Abstract 93(1): 239522d, 1980.

Alferiev, I.S., Kotlyarevskii, I.L., Mikhalin, N.V., Novikova, V.M.: Nucleophilic addition of amines to vinylidenediphosphonic acid. Nzvestiya Akademii Nauk SSSR, Seriya Khimicheskaya Page: 1211-1212, 1980.

Alferiev, I.S., Kozlov, V.A., Kotlyarevskii, I.L., Mikhalin, N.V.,Novikova, V.M.: Immunodepressive effect of N-substituted 2-amino-ethylidene-1, 1-diphosphonic acids. Izyestiya Akademii Nauk SSSR, Seriya Biologicheskaya, Chemical Abstracts 93: 93361b, 1980.

Alferiev, I.S., Kozlov, V.A., Kotlyarevskii, I.L.,Mikhalin, N.V., Novikova, V.M.: Immunodepressive effect of N-substituted 2-amino-ethylidene-1, 1-diphosphonic acids. Izvestiya Akademii Nauk SSSR, Seriya Biologicheskaya 2: 289-292, 1980.

1979

Alferiev, I.S., Kotlyarevskii, I.L., Mikhalin, N.V.: Oxidation of 1-amino-alkylidene-1, 1-diphosphonic acids with bromine in bicarbonate. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science 28(9): 1946-1948 (English Translation), 1979.

2012

I Fishbein, M Chorny, IS Alferiev, RJ Levy: Site Specific Controlled Release for Cardiovascular Disease -Translational Directions. Fundamentals and Applications of Controlled Release Drug Delivery. J. Siepmann, M.J.Rathbone, R.A. Siegel (eds.). Springer, New York, 2012.