Tomas S. Aleman, MD
Areas of expertise: Genetic ophthalmology, Mitochondrial and ophthalmic genetics, Retinal degeneration, Retinal diseases
Locations: Main Building
About Tomas S. Aleman, MD
Titles
Attending Physician
Associate Professor of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania
Awards and Honors
2015, PennMedicine Innovation Accelerator Program Award
2014, National Harold A. Stein, MD Prize for Best Scientific Paper, Joint Commission on Allied Health Personnel in Ophthalmology (JCAHPO) Education and Research Foundation
2012 & 2013, "Exceptional Investigative Ophthalmology & Visual Science Review"
2010, Foundation Fighting Blindness Board of Directors Award
2006-2008, Hope for Vision Award
2001-2005, Foundation Fighting Blindness Career Development Award
1988, Golden Diploma in Medicine, University of Havana, Havana, Cuba
Leadership and Memberships
Memberships in Professional Organizations
International
1994-present, Association for Research in Vision and Ophthalmology
National
12011-present, American Academy of Ophthalmology
1994-present, Cuban Society of Retinitis Pigmentosa
1994-present, Cuban Society of Ophthalmology
Editorial and Academic Positions
Editorial Positions
2016-present, Peer-Reviewer, Proceedings of the National Academy of Sciences
2014-present, Peer-Reviewer, Translational Vision Science and Technology
2003-present, Peer-Reviewer, Investigative Ophthalmology and Visual Sciences
2001-present, Peer-Reviewer, Retina
Education & training
Medical Degree
MD - University of Havana, Havana, Cuba
Internship
Transitional Internship - Hospital Salvador Allende, Havana, Cuba
Internal Medicine - Brookdale University Hospital, New York, NY
Residency
Family Medicine - Policlinico Turcios Lima, Havana, Cuba
Ophthalmology - Hospital Salvador Allende, Havana, Cuba
Ophthalmology - Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA
Fellowship
Research Fellow - Center for Hereditary Retinal Degenerations, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA
Additional Training
Postdoctoral Training in Hereditary Retinal Degenerations - Center for Hereditary Retinal Degenerations, Bascom Palmer Eye Institute, University of Miami, Miami, FL
Publications
Publications
2017
Aleman TS, Sandhu HS, Serrano LW, Traband A, Lau MK, Adamus G, Avery RA. Acute zonal cone photoreceptor outer segment loss. JAMA Ophthalmol. 2017;135(5):487-490.
Swanson JW, Aleman TS, Xu W, Ying GS, Pan W, Liu GT, Lang SS, Heuer GG, Storm PB, Bartlett SP, Katowitz WR, Taylor JA. Evaluation of optical coherence tomography to detect elevated intracranial pressure in children. JAMA Ophthalmol. 2017;135(4):320-328.
2016
Matsui R, McGuigan III DB, Gruzensky ML, Aleman TS, Schwartz SB, Sumaroka A, Koenekoop RK, Cideciyan AV, Jacobson SG: SPATA7: Evolving phenotype from cone-rod dystrophy to retinitis pigmentosa. Ophthalmic genetics 37(3): 333-8, Sep 2016 Notes: Epub 2016 Feb
Fuerst NM, Serrano L, Han G, Morgan JIW, Maguire AMM, Leroy BP, Kim BJ, Aleman TS. 2016; 30:1-8.: Detailed functional and structural phenotype of Bietti crystalline dystrophy associated with mutations in CYP4V2 complicated by choroidal neovascularization. Ophthalmic Genetics 30(4): 1-8, Mar 2016 Notes: Epub ahead of print.
2015
Bonafede L Ficicioglu CH, Serrano L, Han G, Morgan JIW, Mills MD, Forbes BJ, Davidson SL, Binenbaum G, Kaplan PB, Nichols CW, Verloo P, Leroy BP, Maguire AM, Aleman TS. : Cobalamin C deficiency shows a Rapidly Progressing Maculopathy with severe photoreceptor and ganglion cell loss. Invest Ophthalmol Vis Sci. 56(13): 7875-87, Dec 2015.
Swanson J, Xu W, Aleman TS, Mitchell B, Wes A, Chen SS, Bender L, Heuer G, Katowitz W, Bartlett S, Taylor J. : Optical coherence tomography can detect intracranial hypertension in young children with craniosynostosis. Plast Reconstr Surg. 136((4 Suppl)): 39, Oct 2015,
Brodie FL, Charlson ES, Aleman TS, Salvo RT, Lau MK, Farren ND, Engelhard SB, Pistilli M, Brucker AJ. : Obstructive sleep apnea and central serous chorioretinopathy. Retina 35(2): 238-43, Feb 2015.
2014
Aleman TS, Huang J, Garrity ST, Carter SB, Aleman WD, Ying G, Tamhankar MA.: Relationship between optic nerve appearance and retinal nerve fiber thickness as explored with spectral domain optical coherence tomography. Trans Vis Sci Tech 3(6): 4, Nov 2014.
Aleman TS, Brodie F, Garvin C, Gewaily DY, Ficicioglu CH, Mills MD, Forbes BJ, Maguire AM, Davidson SL: Retinal structure in cobalamin C disease: mechanistic and therapeutic implications. Ophthalmic Genetics Feb 2014 Notes: E Pub ahead of print.
2013
Aleman TS, Garrity ST, Brucker AJ.: Retinal structure in vitamin A deficiency as explored with multimodal imaging. Doc. Ophthalmol. 127(3): 239-43, Dec 2013.
Moran AM, Aleman TS, Gausas RE, Fogt F. : Traumatic arteriovenous fistula of the superficial temporal artery: a histopathologic report Ophthal Plast Reconstr Surg. 29(5): 126-8, Sep-Oct 2013.
2012
Aleman TS, Tapino PJ, Brucker AJ : Evidence of Recurrent microvascular occlusions associated with acute branch retinal artery occlusion demonstrated with SD-OCT. Retina 32 (8): 1687-1688, Sep 2012.
Dinculescu A, Estreicher J, Zenteno JC, Aleman TS, Schwartz SB, Huang WC, Roman AJ, Sumaroka A, Li Q, Deng WT, Min SH, Chiodo VA, Neeley A, Liu X, Shu X, Matias-Florentino M, Buentello-Volante B, Boye SL, Cideciyan AV, Hauswirth WW, Jacobson SG. : Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept Hum Gene Ther 23 (4): 367-376, Apr 2012.
Cideciyan AV, Swider M, Aleman TS, Feuer WJ, Schwartz SB, Russell RC, Steinberg JD, Stone EM, Jacobson SG : Macular function in macular degenerations: repeatability of microperimetry as a potential outcome measure for ABCA4-associated retinopathy trials Invest Ophthalmol Vis Sci. 53(2): 841-852, Feb 2012.
Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, Chiodo VA, Fajardo DS, Román AJ, Deng WT, Swider M, Aleman TS, Boye SL, Genini S, Swaroop A, Hauswirth WW, Jacobson SG, Aguirre GD : Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proc Natl Acad Sci U S A. 109 (6): 2132-2137, Feb 2012.
Jacobson SG, Cideciyan AV, Ratnakaram R, Heon E, Schwartz SB, Roman AJ, Peden MC, Aleman TS, Boye SL, Sumaroka A, Conlon TJ, Calcedo R, Pang JJ, Erger KE, Olivares MB, Mullins CL, Swider M, Kaushal S, Feuer WJ, Iannaccone A, Fishman GA, Stone EM, Byrne BJ, Hauswirth WW. : Gene therapy for Leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years. Arch Ophthalmol. 130(1): 9-24, Jan 2012 .
2011
Shu X; Luhmann U, Aleman TS, Barker SE, Lennon A, Tulloch B, Chen M, Xu H, Jacobson SG, Ali R, Wright A: Characterisation of a C1qtnf5 Ser163Arg knock-in mouse model of late-onset retinal macular degeneration. PLoS One 6(11): e27433, Nov 2011.
Jacobson SG, Cideciyan AV, Gibbs D, Sumaroka A, Roman AJ, Aleman TS, Schwartz SB, Olivares MB, Russell RC, Steinberg JD, Kenna MA, Kimberling WJ, Rehm HL, Williams DS: Retinal Disease Course in Usher Syndrome 1B Due to MYO7A Mutations. Invest Ophthalmol Vis Sci. 52(11): 7924-7936, Oct 2011.
Aleman TS, Cideciyan AV, Aguirre GK, Huang WC, Mullins CL, Roman AJ, Sumaroka A, Olivares MB, Tsai FF, Schwartz SB, Vandenberghe LH, Limberis MP, Stone EM, Bell P, Wilson JM, Jacobson SG: Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse model. Invest Ophthalmol Vis Sci. 52 (9): 6898-6910, Aug 2011.
Lopes VS, Gibbs D, Libby R, Aleman TS, Welch DL, Lillo C, Jacobson SG, Roxana RA, Radu A, Steel KP, Williams DS: The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65. Hum Mol Genet 20(13): 2560-2570, Jul 2011.
Cideciyan AV, Rachel RA, Aleman TS, Swider M, Schwartz SB, Sumaroka A, Roman AJ, Stone EM, Jacobson SG, Swaroop A. : Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290) blindness: generation of an all-cone Nphp6 hypomorph mouse that mimics the human retinal ciliopathy. Hum Mol Genet 20(7): 1411-1423, Apr 2011.
Stone EM, Cideciyan AV, Aleman TS, Scheetz TE, Sumaroka A, Ehlinger MA, Schwartz SB, Fishman GA, Traboulsi EI, Lam BL, Fulton AB, Mullins RF, Sheffield VC, Jacobson SG.: Variations in NPHP5 in Patients with Nonsyndromic Leber Congenital Amaurosis (LCA) and Senior-Loken Syndrome. Arch Ophthal 129(1): 81-87, Jan 2011.
Jacobson SG, Cideciyan AV, Aleman TS, Sumaroka A, Roman AJ, Swider M, Schwartz SB, Banin E, Stone EM: Human retinal disease from AIPL1 gene mutations: foveal cone loss with minimal macular photoreceptors and rod function remaining. Invest Ophthalmol Vis Sci 52(1): 70-79, Jan 2011.
2010
Walia S, Fishman GA, Jacobson SG, Aleman TS, Koenekoop RK, Traboulsi EI, Weleber RG, Pennesi ME, Heon E, Drack A, Lam BL, Allikmets R, Stone EM: Visual Acuity in patients with Leber's congenital amaurosis and early childhood-onset retinitis pigmentosa. Ophthalmology 117: 1190-1198, 2010.
Caruso RC, Aleman TS, Cideciyan AV, Roman AJ, Sumaroka A, Mullins Cl, Boye SL, Hauswirth WW, Jacobson SG: Retinal disease in Rpe65-deficient mice: Comparison to human Leber congenital amaurosis due to RPE65 mutations. Invest. Ophthalmol. Vis. Sci. 51: 5304-5313, 2010.
Banin E, Bandah-Rozenfeld D, Obolensky A, Cideciyan AV, Aleman TS, Marks-Ohana D, Sela M, Boye S, Sumaroka A, Roman AJ, Schwartz SB, Hauswirth WW, Jacobson SG, Hemo I, Sharon D. : Molecular anthropology meets genetic medicine to treat blindness in the North African Jewish population: human gene therapy initiated in Israel. Hum Gene Ther 21: 1749-1757, 2010.
2009
Misra GP, Singh RSJ, Aleman TS, Jacobson SG, Gardner TW, Lowe TL: Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina. Biomaterials 30: 6541-6547, 2009.
Maeda T, Cideciyan AV, Maeda A, Golczak M, Aleman TS, Jacobson SG, Palczewski K. : Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate. Hum Mol Genet 18: 2277-2287, 2009.
Jacobson SG, Aleman TS, Cideciyan AV, Sumaroka A, Schwartz SB, Windsor EAM, Swider M, Herrera W, Stone EM. : Leber congenital amaurosis caused by Lebercilin (LCA5) mutation: Retained photoreceptors adjacent to retinal disorganization. Mol Vis 15: 1098-1106, 2009.
Jacobson SG, Aleman TS, Cideciyan AV, Roman AJ, Sumaroka A, Windsor EAM, Schwartz SB, Heon E, Stone EM.: Defining the residual vision in Leber congenital amaurosis caused by RPE65 mutations. Investigative Ophthalmology & Visual Science 50: 2368-2375, 2009.
Jacobson SG, Roman AJ, Aleman TS, Sumaroka A, Herrera W, Windsor EAM, Atkinson LA, Schwartz SB, Steinberg JD, Cideciyan AV: Normal central retinal function and structure preserved in retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 51: 1079-1085, 2009.
Cideciyan AV, Swider M, Aleman TX, Tsybovsky V, Schwartz SB, Windsor EA, Roman AJ, Sumaroka A, Steinberg JC, Jacobson SG, Stone EM, Palczewski K: ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet 18: 931-941, 2009.
Cideciyan AV, Hauswirth W, Aleman TS, Kaushal S, Schwartz SB, Boye SL, Windsor E, Conlon T, Sumaroka A, Pang J, Roman AJ, Byrne B, Jacobson SG. : Human RPE65 gene therapy for Leber congenital amaurosis: Persistence of early visual improvements and safety at one year. Human Gene Therapy 20: 999-1004 2009.
Aleman TS, Soumittra N, Cideciyan AV, Sumaroka AM, Ramprasad VL, Herrera W, Windsor EAM, Schwartz SB, Russell RC, Roman AJ, Inglehearn CF, Kumaramanickavel G, Stone EM, Fishman GA, Jacobson SG: CERKL mutations cause an autosomal recessive cone-rod dystrophy with inner retinopathy. Invest. Ophthalmol. Vis. Sci. 50: 5944-5954, 2009.
Williams DS, Aleman TS, Lillo C, Lopes VS, Hughes LC, Stone EM, Jacobson SG: Harmonin in the murine retina and the retinal phenotypes of Ush1c-mutant mice and human USH1C. Investigative Ophthalmology & Visual Science 50(8): 3881-3889, August 2009.
Jacobson SG, Aleman TS, Cideciyan AV, Roman AJ, Sumaroka A, Windsor EAM, Schwartz SB, Heon E, Stone EM: Defining the residual vision in Leber Congenital Amaurosis caused by RPE65 mutations. Investigative Ophthalmology & Visual Science 50(5): 2368-75, May 2009.
Jacobson SG, Aleman TS, Sumaroka A, Cideciyan AV, Roman AJ, Windsor EAM, Schwartz SB, Rehm HL, Kimberling WJ. : Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations. Investigative Ophthalmology & Visual Science 50(4): 1886-1894, Apr 2009.
2008
Jacobson SG, Cideciyan AV, Aleman TS, Sumaroka A, Windsor EAM, Schwartz SB, Heon E, Stone EM: Photoreceptor layer topography in children with Leber congenital amaurosis caused by RPE65 mutations. Investigative Ophthalmology & Visual Science 49: 4573-4577, 2008.
Herrera W, Aleman TS, Cideciyan AV, Roman AJ, Banin E, Ben-Yosef T, Gardner LM, Sumaroka A, Windsor EA, Schwartz SB, Stone EM, Liu XZ, Kimberling WJ, Jacobson SG.: Retinal disease in Usher Syndrome III caused by mutations in the Clarin-1 gene. Investigative Ophthalmology & Visual Science 49: 2651-2660, 2008.
Cideciyan AV, Aleman TS, Boye SL, Schwartz SB, Kaushal S, Roman AJ, Pang J-j, Sumaroka A, Windsor EAM, Wilson JM, Flotte TR, Fishman GA, Heon E, Stone EM, Byrne BJ, Jacobson SG, Hauswirth WW: Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kenetics. PNAS 105: 15112-15117, 2008.
Aleman TS, Lam BL, Cideciyan AV, Sumaroka A, Windsor EAM, Roman AJ, Schwartz SB, Stone EM, Jacobson, SG: Genetic heterogeneity in autosomal dominant retinitis pigmentosa with low-frequency damped electroretinographic wavelets. Eye 2008 23: 230-233, 2008.
Hauswirth W, Aleman TS, Kaushal S, Cideciyan AV, Schwartz SB, Wang L, Conlon T, Boye SL, Flotte TR, Byrne B, Jacobson SG: Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial. Human Gene Ther 19(10): 979-90, Oct 2008.
Jacobson SG, Cideciyan AV, Aleman TS, Sumaroka A, Roman AJ, Gardner LM, Prosser HM, Mishra M, Bech-Hansen NT, Herrera W, Schwartz SB, Liu XZ, Kimberling WJ, Steel KP, Williams DS.: Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism. Hum Mol Genet 17(15): 2405-2415, Aug 2008.
Aleman TS, Cideciyan AV, Sumaroka A, Windsor EAM, Herrera W, White DA, Kaushal S, Naidu A, Roman AJ, Schwartz SB, Stone EM, Jacobson SG: Retinal Laminar Architecture in Human Retinitis Pigmentosa Caused by Rhodopsin Gene Mutations. Investigative Ophthalmology & Visual Science 49(4): 1580-1590, April 2008.
2007
Cideciyan AV, Aleman TS, Jacobson SG, Khanna H, Sumaroka A, Aguirre GK, Schwartz SB, Windsor EA, He S, Chang B, Stone EM, Swaroop A.: Centrosomal-ciliary gene CEP290/NPHP6 mutations result in blindness with unexpected sparing of photoreceptors and visual brain: implications for therapy of Leber congenital amaurosis. Hum Mutat. 28(11): 1074-1083, Nov 2007.
Aleman TS, Cideciyan AV, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Steinberg JD, Branham K, Othman M, Swaroop A, Jacobson SG.: Inner retinal abnormalities in X-linked retinitis pigmentosa with RPGR mutations. Investigative Ophthalmology & Visual Science 48(10 ): 4759-4765, Oct 2007.
Roman AJ, Boye SL, Aleman TS, Pang JJ, McDowell JH, Boye SE, Cideciyan AV, Jacobson SG, Hauswirth WW.: Electroretinographic analyses of Rpe65-mutant rd12 mice: developing an in vivo bioassay for human gene therapy trials of Leber congenital amaurosis. Mol Vis. 13: 1701-1710, Sep 2007.
Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K.: Human cone photoreceptor dependence on RPE65 isomerase. Proc. Natl. Acad. Sci. USA. 104(38): 15123-15128, Sep 2007.
Roman AJ, Cideciyan AV, Aleman TS, Jacobson SG.: Full-field stimulus testing (FST) to quantify visual perception in severely blind candidates for treatment trials. Physiol Meas. 28(8): N51-56, Aug 2007.
Aguirre GK, Komaromy AM, Cideciyan AV, Brainard DH, Aleman TS, Roman AJ, Avants BB, Gee JC, Korczykowski M, Hauswirth WW, Acland GM, Aguirre GD, Jacobson SG.: Canine and human visual cortex intact and responsive despite early retinal blindness from RPE65 mutation. PLoS Med. 4(6 ): e230, Jun 2007.
Jacobson SG, Sumaroka A, Aleman TS, Cideciyan AV, Danciger M, Farber DB.: Evidence for retinal remodeling in retinitis pigmentosa caused by PDEβ mutation. BJO 91(5): 699-701, May 2007.
Jacobson SG, Cideciyan AV, Aleman TS, Sumaroka A, Schwartz SB, Roman AJ, Stone EM.: Leber congenital amaurosis caused by an RPGRIP1 mutation shows treatment potential. Ophthalmology 114(5): 895-898, May 2007.
Aleman TS, Cideciyan AV, Windsor EA, Schwartz SB, Swider M, Chico JD, Sumaroka A, Pantelyat AY, Duncan KG, Gardner LM, Emmons JM, Steinberg JD, Stone EM, Jacobson SG.: Macular pigment and lutein supplementation in ABCA4-associated retinal degenerations. Investigative Ophthalmology & Visual Science 48(3): 1319-1329, Mar 2007.
Jacobson SG, Cideciyan AV, Aleman TS, Sumaroka A, Schwartz SB, Windsor EA, Roman AJ, Heon E, Stone EM, Thompson DA.: RDH12 and RPE65, visual cycle genes causing leber congenital amaurosis, differ in disease expression. Investigative Ophthalmology & Visual Science 48(1): 332-338, Jan 2007.
2006
Jacobson SG, Cideciyan AV, Sumaroka A, Aleman TS, Schwartz SB, Windsor EA, Roman AJ, Stone EM, MacDonald IM.: Free Full Text Remodeling of the human retina in choroideremia: rab escort protein 1 (REP-1) mutations. Invest Ophthalmol Vis Sci. 47(9): 4113-4120, 2006.
Azari AA, Aleman TS, Cideciyan AV, Schwartz SB, Windsor EA, Sumaroka A, Cheung AY, Steinberg JD, Roman AJ, Stone EM, Sheffield VC, Jacobson SG.: Retinal disease expression in Bardet-Biedl syndrome-1 (BBS1) is a spectrum from maculopathy to retina-wide degeneration. Invest Ophthalmol Vis Sci. 47(11): 5004-5010, Nov 2006.
Jacobson SG., Cideciyan AV., Sumaroka A., Aleman TS., Schwartz SB., Windsor EA., Roman AJ., Stone EM., MacDonald IM.: Remodeling of the human retina in choroideremia: rab escort protein 1 (REP-1) mutations. Investigative Ophthalmology & Visual Science 47(9): 4113-20, Sep 2006.
Cheng H, Aleman TS, Cideciyan AV, Khanna R, Jacobson SG, Swaroop A.: In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development. Hum Mol Genet. 15(17): 2588-2602, Sep 2006.
Jacobson SG., Boye SL., Aleman TS., Conlon TJ., Zeiss CJ., Roman AJ., Cideciyan AV., Schwartz SB., Komaromy AM., Doobrajh M., Cheung AY., Sumaroka A., Pearce-Kelling SE., Aguirre GD., Kaushal S., Maguire AM., Flotte TR., Hauswirth WW.: Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis. Human Gene Therapy 17(8): 845-58, Aug 2006.
Jacobson SG, Boye SL, Aleman TS, Conlon TJ, Zeiss CJ, Roman AJ, Cideciyan AV, Schwartz SB, Komaromy AM, Doobrajh M, Cheung AY, Sumaroka A, Pearce-Kelling SE, Aguirre GD, Kaushal S, Maguire AM, Flotte TR, Hauswirth WW.: Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis. Hum Gene Ther. 17(8): 845-858, Aug 2006.
Williams ML, Coleman JE, Haire SE, Aleman TS, Cideciyan AV, Sokal I, Palczewski K, Jacobson SG, Semple-Rowland SL.: Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Med. 3(6): e201, Jun 2006.
Jacobson SG., Acland GM., Aguirre GD., Aleman TS., Schwartz SB., Cideciyan AV., Zeiss CJ., Komaromy AM., Kaushal S., Roman AJ., Windsor EA., Sumaroka A., Pearce-Kelling SE., Conlon TJ., Chiodo VA., Boye SL., Flotte TR., Maguire AM., Bennett J., Hauswirth WW.: Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection. Molecular Therapy: the Journal of the American Society of Gene Therapy 13(6): 1074-84, Jun 2006.
2005
Cideciyan AV., Swider M., Aleman TS., Sumaroka A., Schwartz SB., Roman MI., Milam AH., Bennett J., Stone EM., Jacobson SG.: ABCA4-associated retinal degenerations spare structure and function of the human parapapillary retina. Investigative Ophthalmology & Visual Science 46(12): 4739-46, Dec 2005.
Acland GM., Aguirre GD., Bennett J., Aleman TS., Cideciyan AV., Bennicelli J., Dejneka NS., Pearce-Kelling SE., Maguire AM., Palczewski K., Hauswirth WW., Jacobson SG.: Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Molecular Therapy: the Journal of the American Society of Gene Therapy 12(6): 1072-82, Dec 2005.
Dunaief JL., Richa C., Franks EP., Schultze RL., Aleman TS., Schenck JF., Zimmerman EA., Brooks DG.: Macular degeneration in a patient with aceruloplasminemia, a disease associated with retinal iron overload. Ophthalmology 112(6): 1062-5, Jun 2005.
Lebherz C., Maguire AM., Auricchio A., Tang W., Aleman TS., Wei Z., Grant R., Cideciyan AV., Jacobson SG., Wilson JM., Bennett J.: Nonhuman primate models for diabetic ocular neovascularization using AAV2-mediated overexpression of vascular endothelial growth factor. Diabetes 54(4): 1141-9, Apr 2005.
Jacobson SG., Aleman TS., Cideciyan AV., Sumaroka A., Schwartz SB., Windsor EA., Traboulsi EI., Heon E., Pittler SJ., Milam AH., Maguire AM., Palczewski K., Stone EM., Bennett J.: Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proc. Natl. Acad. Sci. USA. 102(17): 6177-82, Apr 26 2005.
Cideciyan AV., Jacobson SG., Aleman TS., Gu D., Pearce-Kelling SE., Sumaroka A., Acland GM., Aguirre GD.: In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa. PNAS 102(14): 5233-8, Apr 2005.
Schwartz SB., Aleman TS., Cideciyan AV., Windsor EA., Sumaroka A., Roman AJ., Rane T., Smilko EE., Bennett J., Stone EM., Kimberling WJ., Liu XZ., Jacobson SG.: Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype. Investigative Ophthalmology & Visual Science 46(2): 734-43, Feb 2005.
Roman AJ., Schwartz SB., Aleman TS., Cideciyan AV., Chico JD., Windsor EA., Gardner LM., Ying GS., Smilko EE., Maguire MG., Jacobson SG.: Quantifying rod photoreceptor-mediated vision in retinal degenerations: dark-adapted thresholds as outcome measures. Experimental Eye Research 80(2): 259-72, Feb 2005.
2004
Wright AF., Reddick AC., Schwartz SB., Ferguson JS., Aleman TS., Kellner U., Jurklies B., Schuster A., Zrenner E., Wissinger B., Lennon A., Shu X., Cideciyan AV., Stone EM., Jacobson SG., Swaroop A.: Mutation analysis of NR2E3 and NRL genes in Enhanced S Cone Syndrome. Human Mutation 24(5): 439, Nov 2004.
Jacobson SG., Sumaroka A., Aleman TS., Cideciyan AV., Schwartz SB., Roman AJ., McInnes RR., Sheffield VC., Stone EM., Swaroop A., Wright AF.: Nuclear receptor NR2E3 gene mutations distort human retinal laminar architecture and cause an unusual degeneration. Human Molecular Genetics 13(17): 1893-902, Sep 1 2004.
Aleman TS., Jacobson SG., Chico JD., Scott ML., Cheung AY., Windsor EA., Furushima M., Redmond TM., Bennett J., Palczewski K., Cideciyan AV.: Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. Investigative Ophthalmology & Visual Science 45(4): 1259-71, Apr 2004.
Cideciyan AV., Aleman TS., Swider M., Schwartz SB., Steinberg JD., Brucker AJ., Maguire AM., Bennett J., Stone EM., Jacobson SG.: Mutations in ABCA4 result in accumulation of lipofuscin before slowing of the retinoid cycle: a reappraisal of the human disease sequence. Human Molecular Genetics 13(5): 525-34, Mar 1 2004.
Dejneka NS., Surace EM., Aleman TS., Cideciyan AV., Lyubarsky A., Savchenko A., Redmond TM., Tang W., Wei Z., Rex TS., Glover E., Maguire AM., Pugh EN Jr., Jacobson SG., Bennett J.: In utero gene therapy rescues vision in a murine model of congenital blindness. Molecular Therapy: the Journal of the American Society of Gene Therapy 9(2): 182-8, Feb 2004.
2003
Schwartz SB., Aleman TS., Cideciyan AV., Swaroop A., Jacobson SG., Stone EM.: De novo mutation in the RP1 gene (Arg677ter) associated with retinitis pigmentosa. Investigative Ophthalmology & Visual Science 44(8): 3593-7, Aug 2003.
Jacobson SG., Cideciyan AV., Aleman TS., Pianta MJ., Sumaroka A., Schwartz SB., Smilko EE., Milam AH., Sheffield VC., Stone EM.: Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal lamination. Human Molecular Genetics 12(9): 1073-8, May 2003.
Milam AH., Barakat MR., Gupta N., Rose L., Aleman TS., Pianta MJ., Cideciyan AV., Sheffield VC., Stone EM., Jacobson SG.: Clinicopathologic effects of mutant GUCY2D in Leber congenital amaurosis. Ophthalmology 110(3): 549-58, Mar 2003.
Pianta MJ., Aleman TS., Cideciyan AV., Sunness JS., Li Y., Campochiaro BA., Campochiaro PA., Zack DJ., Stone EM., Jacobson SG.: In vivo micropathology of Best macular dystrophy with optical coherence tomography. Experimental Eye Research 76(2): 203-11, Feb 2003.
2002
Aleman TS., Cideciyan AV., Volpe NJ., Stevanin G., Brice A., Jacobson SG.: Spinocerebellar ataxia type 7 (SCA7) shows a cone-rod dystrophy phenotype. Experimental Eye Research 74(6): 737-45, Jun 2002.
Kijas JW., Cideciyan AV., Aleman TS., Pianta MJ., Pearce-Kelling SE., Miller BJ., Jacobson SG., Aguirre GD., Acland GM.: Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America 99(9): 6328-33, Apr 30 2002.
Duncan JL., Aleman TS., Gardner LM., De Castro E., Marks DA., Emmons JM., Bieber ML., Steinberg JD., Bennett J., Stone EM., MacDonald IM., Cideciyan AV., Maguire MG., Jacobson SG.: Macular pigment and lutein supplementation in choroideremia. Experimental Eye Research 74(3): 371-81, Mar 2002.
Milam AH., Rose L., Cideciyan AV., Barakat MR., Tang WX., Gupta N., Aleman TS., Wright AF., Stone EM., Sheffield VC., Jacobson SG.: The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration. Proceedings of the National Academy of Sciences of the United States of America 99(1): 473-8, Jan 8 2002.
2001
Liang FQ., Aleman TS., Dejneka NS., Dudus L., Fisher KJ., Maguire AM., Jacobson SG., Bennett J.: Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa. Molecular Therapy: the Journal of the American Society of Gene Therapy 4(5): 461-72, Nov 2001.
Aleman TS., LaVail MM., Montemayor R., Ying G., Maguire MM., Laties AM., Jacobson SG., Cideciyan AV.: Augmented rod bipolar cell function in partial receptor loss: an ERG study in P23H rhodopsin transgenic and aging normal rats. Vision Research 41(21): 2779-97, Sep 2001.
Aleman TS., Duncan JL., Bieber ML., de Castro E., Marks DA., Gardner LM., Steinberg JD., Cideciyan AV., Maguire MG., Jacobson SG.: Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome. Investigative Ophthalmology & Visual Science 42(8): 1873-81, Jul 2001.
Acland GM., Aguirre GD., Ray J., Zhang Q., Aleman TS., Cideciyan AV., Pearce-Kelling SE., Anand V., Zeng Y., Maguire AM., Jacobson SG., Hauswirth WW., Bennett J.: Gene therapy restores vision in a canine model of childhood blindness. Nature Genetics 28(1): 92-5, May 2001.
Liang FQ., Aleman TS., ZaixinYang., Cideciyan AV., Jacobson SG., Bennett J.: Melatonin delays photoreceptor degeneration in the rds/rds mouse. NeuroReport 12(5): 1011-4, Apr 17 2001.
Pearce-Kelling SE., Aleman TS., Nickle A., Laties AM., Aguirre GD., Jacobson SG., Acland GM.: Calcium channel blocker D-cis-diltiazem does not slow retinal degeneration in the PDE6B mutant rcd1 canine model of retinitis pigmentosa. Molecular Vision 7: 42-7, Feb 25 2001.
2000
Poehner WJ., Fossarello M., Rapoport AL., Aleman TS., Cideciyan AV., Jacobson SG., Wright AF., Danciger M., Farber DB.: A homozygous deletion in RPE65 in a small Sardinian family with autosomal recessive retinal dystrophy. Molecular Vision 6: 192-8, Oct 30 2000.
Cideciyan AV., Haeseleer F., Fariss RN., Aleman TS., Jang GF., Verlinde CL., Marmor MF., Jacobson SG., Palczewski K.: Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man. Visual Neuroscience 17(5): 667-78, Sep-Oct 2000.
Van Hooser JP., Aleman TS., He YG., Cideciyan AV., Kuksa V., Pittler SJ., Stone EM., Jacobson SG., Palczewski K.: Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proceedings of the National Academy of Sciences of the United States of America 97(15): 8623-8, Jul 18 2000.
Huang Y., Cideciyan AV., Aleman TS., Banin E., Huang J., Syed NA., Petters RM., Wong F., Milam AH., Jacobson SG.: Optical coherence tomography (OCT) abnormalities in rhodopsin mutant transgenic swine with retinal degeneration. Experimental Eye Research 70(2): 247-51, Feb 2000.
1999
Banin E, Cideciyan AV, Aleman TS, Petters RM, Wong F, Milam AH,Jacobson SG: Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development. Neuro 23: 549-557, 1999.
Lewis CA., Batlle IR., Batlle KG., Banerjee P., Cideciyan AV., Huang J., Aleman TS., Huang Y., Ott J., Gilliam TC., Knowles JA., Jacobson SG.: Tubby-like protein 1 homozygous splice-site mutation causes early-onset severe retinal degeneration. Investigative Ophthalmology & Visual Science 40(9): 2106-14, Aug 1999.
Bennett J., Maguire AM., Cideciyan AV., Schnell M., Glover E., Anand V., Aleman TS., Chirmule N., Gupta AR., Huang Y., Gao GP., Nyberg WC., Tazelaar J., Hughes J., Wilson JM., Jacobson SG.: Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina. Proceedings of the National Academy of Sciences of the United States of America 96(17): 9920-5, Aug 17 1999.
1995
Moreno N., Aleman T.S., Herrera M., Peláez O. : Syndromes most frequently associated with retinitis pigmentosa Cuba. Arch. Chil. Oftal. 52: 39-43, 1995.
1988
Aleman TS, Echeverria RE, Aleman ST.: Some methodological considerations about lecturing programs in ambulatory health care. Rev. Educ. Med. Sup. 2: 1, 1988.
Aleman TS, Echeverria RE. : Laser in Medicine. Rev. 141: 2-8, April 1988.
Lectures by Invitation
2016
Aleman TS. "Stargardt Disease, Cone-Rod Dystrophy & Best Disease", Foundation Fighting Blindness Visions 2016 Conference, Baltimore, MD. Jul, 2016.
Aleman TS. "The Doctor is In", Panel member, Open Q & A with panel of Doctors, Choroideremia Research Foundation 2016 Conference, Philadelphia, PA. Jun, 2016.
Aleman TS. "Understanding Choroideremia", Choroideremia Research Foundation 2016 Conference, Philadelphia, PA. Jun, 2016
Aleman TS. "Gene Therapy for Inherited Retinal Degenerations", Curso Internacional de Avances e Innovación en Oftalmología, Monterrey, Mexico. Apr, 2016.
Aleman TS. "Gene Therapy for Choroideremia: Current and Future Strategies", SIG Meeting, Association for Research in Vision and Ophthalmology Annual Meeting, Seattle, WA. Apr, 2016.
Aleman TS. "Phase I/II Safety Study of Subretinal Injections of AAV2-hCHM in Patients with Choroideremia Two; Interim Results", Spark Therapeutics Scientific Advisory Meeting, Philadelphia, PA. Mar, 2016.