Research Studies

Neuroblastoma Research Studies

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Clinical trial
Adults (4)
Children (4)
MRI/Imaging Studies (1)

Clinical Trial Phases
Phase I (3)
Phase II (3)

Recruitment Status
Recruiting (3)
Non-recruiting (1)

Related conditions
Neuroblastoma (4)
Osteosarcoma (bone cancer in children) (1)

Related Specialties and Programs
Cancer Center (4)
Solid Tumor Program (3)
Cancer Immunotherapy Program (1)
Center for Precision Medicine for High-Risk Pediatric Cancer (1)

Specialty
Oncology (4)

Afamitresgene Autoleucel in Pediatric Subjects with MAGE-A4 Positive Tumors
This study involves an investigational cellular therapy called Afamitresgene Autoleucel. The overall goal of this study is to find out how safe and effective this cellular therapy is in treating people that have been diagnosed with synovial sarcoma, malignant peripheral nerve sheath tumors (MPNST), neuroblastoma or osteosarcoma that has grown or returned after being treated.   

Phase: Phase I, Phase II

Actively recruiting: Yes

Category: Adults, Children

Conditions: Neuroblastoma

GD2CART for Osteosarcoma or Neuroblastoma
This study enrolls patients that have been diagnosed with osteosarcoma or neuroblastoma that has come back (relapsed) or has not responded to standard treatments (refractory). This study involves an investigational cellular therapy called GD2CART. The study will be testing different doses of the study drug to find the safest dose.

Phase: Phase I

Actively recruiting: Yes

Category: Adults, Children

Conditions: Neuroblastoma, Osteosarcoma (bone cancer in children)

NEPENTHE - Next Generation Personalized Neuroblastoma Therapy
This is a clinical trial for patients with neuroblastoma that has returned (relapsed) or has not responded to standard treatment. The patients will have a biopsy of their tumor that will be tested for genetic changes and then matched to available drugs. If the results from the testing show molecular features in the tumor that allow for study treatment, patients will be invited for further testing to see if they are eligible for new treatments. Experimental therapies are all taken orally and may consist of one drug or a combination of drugs

Phase: Phase I, Phase II

Actively recruiting: No

Category: Adults, Children, MRI/Imaging Studies

Conditions: Neuroblastoma

Palbociclib, Irinotecan, and Temozolomide in Ewing Sarcoma
The purpose of the Phase 2 portion of this study is to evaluate the safety and efficacy of the study drug called palbociclib when given in combination with two other drugs (temozolomide and irinotecan) in patients with Ewing sarcoma and when given in combination with topotecan and cyclophosphamide in patients with neuroblastoma.

Phase: Phase II

Actively recruiting: Yes

Category: Adults, Children

Conditions: Neuroblastoma