This study involves taking a study drug called selpercatinib. The overall goal of this study is to find out how effective the study drug is in combination with radioactive iodine (I-131) in treating people with thyroid cancer. The study drug will be given in combination with treatments you will receive as part of your regular cancer care (I-131 and thyrotropin alfa).
Phase: Phase II
Actively recruiting: Yes
Category: Adults, Children
Conditions: Thyroid Cancer in Children, Medullary Thyroid Cancer
This study enrolls patients with newly diagnosed differentiated thyroid cancer (papillary thyroid cancer or follicular thyroid cancer) that has spread to the lungs and has a genetic mutation called and RET fusion. The study involves taking a study drug called selpercatinib for approximately 6 months prior to receiving radioiodine therapy (RAI). The overall goal of this study is to find out if taking the study drug before RAI works better than receiving RAI alone (the usual standard of care treatment).
Phase: Phase II
Actively recruiting: Yes
Category: Adults, Children, MRI/Imaging Studies
Conditions: Thyroid Cancer in Children, Medullary Thyroid Cancer