Rodney M. Camire, PhD
About Rodney M. Camire, PhD
Dr. Rodney M. Camire is a Professor of Pediatrics in the Perelman School of Medicine at The University of Pennsylvania and a member of the Division of Hematology at Children’s Hospital of Philadelphia. He is also a member of the Raymond G. Perelman Center for Cellular and Molecular Therapeutics.
Rodney currently holds Children’s Hospital Endowed Chair in Hematology Research. His laboratory is interested in the molecular and cellular processes that contribute to and regulate blood coagulation and has over 15 years of experience studying the biochemistry of clotting factors. His laboratory has developed several novel clotting factors which are in preclinical/clinical development for the treatment of hemophilia and bleeding and he holds over 15 patents. In addition to translational work, his laboratory is interested in questions related to the enzymology, biochemistry and molecular genetics of enzyme complexes of blood coagulation with an emphasis on factors X, V, FIX and VIII.
He has been funded from the NIH since 2003 and has published over 60 primary and review articles related to blood coagulation. Dr. Camire is as an Associate Editor for the Journal of Thrombosis and Haemostasis and is active with a variety of organizations sitting on the board of directors of the North American Society on Thrombosis and Hemostasis and Thrombosis and Hemostasis Societies of North America. He received his B.A. from Saint Anselm College and his PhD in biochemistry from The University of Vermont.
Titles
Professor, Department of Pediatrics
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Awards and Honors
2017, 18th ISTH Biennial Award for Contributions to Hemostasis (BACH)-Investigator Recognition Award, International Society of Thrombosis and Hemostasis.
2016, F1000 Prime Faculty Member
2014, The Children's Hospital of Philadelphia Endowed Chair in Hematology Research, CHOP
2012, Martin Villar Hemostasis Award (1st Prize), Grifols
2009, Copernicus Visiting Scientist-IUSS-Ferrara 1391, University of Ferrara
2009, Alumni Academic Achievement Award, Saint Anslem College
2005, Young Investigator Award, XXth Congress of the International Society on Thrombosis and Haemostasis
2005, Early Career Investigator Award, The Bayer Hemophilia Awards Program, Bayer Corporation
2003, American Heart Association (Penn/Del) Research Award, President's Reception
2001, Young Investigator Award, XVIIIth Congress of the International Society on Thrombosis and Haemostasis
2001, Young Investigator Award, 43rd Annual Meeting of the American Society of Hematology
2000, Ruth L. Kirschstein National Research Service Award, NIH
2000, Young Investigator Award, 42nd Annual Meeting of the American Society of Hematology
2000, Best Poster Presentation by a Postdoctoral Fellow, Cardiovascular Biology Retreat, University of Pennsylvania
1999, Young Investigator Award, XVIIth Congress of the International Society on Thrombosis and Haemostasis
1997, Young Investigator Award, 39th Annual Meeting of the American Society of Hematology
1997, Graduate Research Forum (2nd Prize), University of Vermont
1997, Young Investigator Award, XVIth Congress of the International Society on Thrombosis and Haemostasis
1996, Graduate Research Forum (1st Prize), University of Vermont
1995, Young Investigator Award, 37th Annual Meeting of the American Society of Hematology
1995, Graduate Research Forum (1st Prize), University of Vermont
1994, Biology Department Award, Saint Anselm College
1994, Magna cum laude, Saint Anselm College
Leadership and Memberships
Memberships in Professional Organizations and Honorary Societies
International
2017-present, Pfizer Global ASPIRE Hemophilia Grant Review Panel
2013-present, North American Society of Thrombosis and Hemostasis
- 2016-present, Chair of Board
- 2013-present, Board of Directors
2006-present, International Society of Thrombosis and Hemostasis
- 2011-2017, Scientific Advisory Board
National
2014-2017, The American Society of Hematology, Scientific Committee on Hemostasis
- 2016, Vice Chair- 2017, Chair
2006-present, American Heart Association
- 2015-2018, ATVB Scientific Sessions Programming Committee
2001-present, The American Society of Hematology
1998-present, American Association for the Advancement of Science
1994-present, Delta Epsilon Sigma
Editorial and Academic Positions
Editorial Positions
2017-present, Reviewer, The Proceedings of the National Academy of Sciences
2014-present, Reviewer, Reviews on Recent Clinical Trials
2013-present, Reviewer, Translational Research
2013-present, Reviewer, Nature Medicine
2013-present, Associate Editor, Journal of Thrombosis and Haemostasis
2012-present, Reviewer, Journal of Cellular and Molecular Medicine
2011-present, Reviewer, Haemophilia
2010-present, Reviewer, The Journal of Biological Chemistry
2010-present, Editorial Board, ISRN Hematology
2009-present, Reviewer, FEBS Letters
2008-present, Reviewer, Thrombosis and Haemostasis
2007-present, Reviewer, Protein Peptide Letters
2007-present, Reviewer, Haematologica
2007-present, Reviewer, The Journal of Clinical Investigation
2006-present, Reviewer, Biochemistry
2006-present, Reviewer, Thrombosis Research
2005-present, Reviewer, American Journal of Hematology
2004-present, Reviewer, Blood Coagulation and Fibrinolysis
2003-present, Reviewer, Journal of Thrombosis and Haemostasis
2003-present, Reviewer, Blood
Academic and Institutional Committees
2018-present, Research Trainee Advisory Committee, CHOP
2016-present, Space Committee, CHOP Research Institute
2014-present, Advisory Committee, Hematology Clinical Research Training Program, UPENN
2014-present, Institutional Intellectual Property Advisory Committee (IIPAC), CHOP
Education & training
Graduate Degree
PhD in Biochemistry - University of Vermont, Burlington, VT
Fellowship
Post-doctoral Fellow in Pediatrics/Hematology - University of Pennsylvania, Philadelphia, PA
Post-doctoral Fellow in Biochemistry - University of Vermont, Burlington, VT
Publications
Publications
2018
Jarocha, D., Vo, K.K., Lyde, R.B., Hayes, V., Camire, R.M., and Poncz, M: Enhancing functional platelet release in vivo from in vitro-grown megakaryocytic using small molecule inhibitors. Blood Advances 2(6): 597-606, 2018.
Gunaratne, R., Kumar, S., Frederiksen, J.W., Stayrook, S., Lohrmann, J.L., Perry, K., Bompiani, K.M., Chabada, C.V., Thalji, N.K., Ho, M.D., Arepally, G., Camire, R.M., Krishnaswamy, K., and Sullenger, B.A: Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass. Nat. Biotechnol. In Press, 2018.
2017
Vadivel, K., Kumar, Y., Bunce, M.W., Camire, R.M., Bajaj, M.S., and Bajaj, S.P: Interaction of factor V B-domain acidic region with its basic region and TFPI/TFPI2: Structural insights from molecular modeling studies. International Biology Review 1(1): 1-12, 2017.
Sim, X., Jarocha, D., Hayes, V., Haney, H.A., Marks, M.S., Camire, R.M., French, D.L., Poncz, M., and Gadue, P: Identifying and enriching the platelet-producing human stem cell-derived megakaryocytic using factor V uptake. Blood 130: 192-204, 2017 Notes: Commentary on paper/Cover page of journal.
Santamaria, S., Reglinska-Matveyev, N., Gierula, M., Camire, R.M., Crawley, J.T.B., Lane, D.A., and Ahnstrom, J: Factor V anticoagulant cofactor activity that targets the early phase of coagulation. J. Biol. Chem. 292: 9335-9344, 2017.
Polderdijk, S.G.I., Adams, T.E., Ivanciu, L., Camire, R.M., Baglin, T.P., and Huntington, J.A: Design and characterization of an APC-specific serpin for the treatment of hemophilia. Blood 129(1): 105-113, 2017.
Nguyen, G.N., George, L.A., Siner, J.I., Davidson, R.J., Zander, C.B., Zheng, X.L., Arruda, V.R., Camire, R.M., and Sabatino, S.E: Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A. J. Thromb. Haemost. 15(1): 110-121, 2017.
Lee, E. J., Dykas, D. J., Leavitt, A. D., Camire, R. M., Ebberink, E., de Frutos, P. G., Gnanasambandan, K., Gu, S.X., Huntington, J.A., Lentz, S.R., Mertens, K., Parish, C.R., Rezaie, A.R., Sayeski, P.P., Cromwell, C., Bar, N., Halene, S., Neparidze, N., Parker, T.L., Burns, A.J., Dumont, A., Yao, X., Lyad Ochao Chaar, C., Connors, J.M., Bale, A.E., and Lee, A.I: Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Advances 1(16): 1224-1237, 2017.
2016
Thalji, N.K., Ivanciu, L., Davidson, R., Gimotty, P.A., Krishnaswamy, S., and Camire, R.M: A rapid pro-hemostatic approach to overcome direct oral anticoagulants. Nat. Med. 22(8): 924-932, 2016.
Siner, J.I., Samelson-Jones, B.J., Crudele, J.M., French, R.A., Lee, B.J., Zhou, S., Merricks, E., Raymer, R., Nichols, T.C., Camire, R.M., and Arruda, V.R: Circumventing burin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models. JCI Insight. 2016 Oct 6;1(16):e89371.
Nguyen, G.N., George, L.A., Siner, J.I., Davidson, R.J., Zander, C.B., Zheng, X.L., Arruda, V.R., Camire, R.M., and Sabatino, S.E: Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A. J Thromb Haemost. 2016 Oct 17. doi: 10.1111/jth.13543. [Epub ahead of print]
2015
Sehgal, A. , Barros, S., Ivanciu, L., Cooley, B., Qin, J., Racie, T., Hettinger J., Carioto, M., Jiang, Y., Brodsky, J., Prabhala, H., Zhang, X., Attarwala, H., Hutabarat, R., Foster, D., Milstein, S., Charisse, K., Kuchimanchi, S., Maier, M.A., Nechev, L., Sorensen, B., Simon, A.R., Dargaud, Y., Negrier, C., Camire, R.M., and Akinc, A: An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia. Nat. Med. 21(5): 492-497, 2015.
Liang, H., Kerschen, E.J., Basu, S., Hernandez, I., Zogg, M., Jia, S., Hessner, M.J., Toso, R., Rezaie, A., Fernandez J.A., Camire, R.M., Ruf, W., Griffin, J.H., and Weiler, H: Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice. Blood 126(21): 2415-2423, 2015.
Hui, D.J., Edmonson S.C., Podsakoff G.M., Pien G.C., Ivanciu L., Camire R.M., Ertl H., Mingozzi F., High K.A., and Basner-Tschakarjan E: AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes. Mol. There. Methods Clin. Dev. 2: 15029, 2015.
George, L.A., Thalji, N.K., Raffini, L.J., Gimotty, P.A. and Camire, R.M: Correction of human hemophilia A whole blood abnormalities with a novel bypass agent: zymogen-like FXa(I16L). J. Thromb. Haemost. 13(9): 1694-1698, 2015.
Baroni, M., Pavani, G., Pinotti, M., Branchini, A., Bernardi, F., and Camire, R.M: Asymmetric processing of mutant factor X Arg386Cys reveals differences between intrinsic and extrinsic pathway activation. Biochim. Biophys. Acta. 1854(10 Pt A): 1351-1356, 2015.
2014
Vadivel, K., Ponnuraj, S., Kumar, Y., Zaiss, A.K., Bunce, M.W., Camire, R.M., Wu, L., Evseenko, D., Herschman, H.R., Bajaj, M.S., and Bajaj, S.P: Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis. J. Biol. Chem. 289(45): 31647-31661, 2014.
Greene, T.K., Zhai, L., Razzo, B.M., Vo, K., Sabatino, D., Camire, R.M., Arruda, V.R., and Poncz, M: Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet-based gene therapy. J. Thromb. Haemost. 12(12): 2102-2112, 2014.
Lectures by Invitation
2018
Camire RM. "Alternative Approaches to Hemophilia Treatment", Pfizer Satellite Symposium, World Federation of Hemophilia, Glasgow, Scotland. May, 2018.
Camire RM. Modifiers of the Bleeding Phenotype in Hemophilia", Eastern Pennsylvania NHF Chapter, Philadelphia, PA.. May, 2018.
Camire RM. "Regulation of Coagulation Factor V: New Mechanistic Insights and Clinical Consequences", McMaster University, Hamilton, Ontario Canada. Apr, 2018.
2017
Camire RM. "Bioengineered Factor Xa as a Therapeutic Strategy to Treat Bleeding" Earl W. Davie Symposium, The Centre for Blood Research, The University of British Columbia, Vancouver, BC, Canada. Nov, 2017.
Camire RM. "Zymogen Transition of Clotting Factors" State of the Art Session, XXVI Congress of The International Society of Thrombosis and Haemostasis, Berlin, Germany. Jul, 2017.
2016
Camire RM. "New Regulatory Aspects of Coagulation Factor V-Biochemical and Clinical Consequences", Emory University, Atlanta, GA. Nov, 2016.
Camire RM. "Rethinking Events in the Hemostatic Process" Plenary Session 2016 World Federation of Hemophilia World Congress; 2016 Jul; Orlando, FL.
Camire RM. "Rediscovering Factor V: Mechanisms Regulating FV Activation and Function" 2016 Gordon Research Conference in Hemostasis, Stowe, VT.
Camire RM. "Anticoagulation-induced Bleeding-Therapeutic Strategies" 8th Symposium on Hemostasis-Translational and Basic Science Discoveries; 2016 May; Chapel Hill, NC.
Camire RM. "Novel Protein Strategies for Hemophilia Treatment" XXXVI World Congress of the International Society of Hematology; 2016 Apr; Glasgow, Scotland.
Camire RM. "Novel Procoagulant Approaches to Treat Bleeding" Louisiana State University, Department of Biochemistry;2016 Mar; New Orleans, LA.
2015
Camire RM. "Mechanisms Regulating FV Activation and Function" Novo Nordisk Workshop on TFPI/Protein S/Factor V; 2015 Nov; Favrholm, Denmark.
Camire RM. "Hemostasis and Novel Hemophilia Therapeutics" Keynote Speaker, Hematology Association of Ireland; 2015 Oct; Galway, Ireland.
Camire RM. "Activation Complex Formation" NHLBI Working Group on the Mechanisms of Inhibitor Development in Hemophilia; 2015 Jun; Washington, DC.
Camire RM. "New Insights into Coagulation Factor V and TFPI Interactions" Abstract Symposia, XXV Congress of The International Society of Thrombosis and Haemostasis; 2015 Jun; Toronto, Canada.
Camire RM. "Re-Engineering Factor Xa to Treat Bleeding" The University of Ferrara; 2015 May; Ferrara, Italy.
Camire RM. "Bioengineering FVIII Function" Pfizer Research; 2015 Apr; Collegeville, PA.
Editorials, Reviews, Chapters
2012
Camire, R.M. and Margaritis, P: Genetics of Coagulation. Hemostasis and Thrombosis: Basic Principles & Clinical Practice, 6th Edition. Marder, V.J., Aird, W.C., Bennett, J.S., Schulman, S. and White, G.C. (eds.). Lippincott Williams & Wilkins, Philadelphia, PA. Chapter 10: 146-162, 2012.
2006
Camire, R.M. and Pollak, E.S: Genetics of Coagulation Hemostasis and Thrombosis: Basic Principles & Clinical Practice, 5th Edition. Colman, R.W., Marder, V.J., Clowes, A.W., George, J.N., and Goldhaber, S.Z. (eds.). Lippincott Williams & Wilkins, Philadelphia, PA. Chapter 4: 59-89, 2006.
2003
Camire, R.M., Larson, P.J., High, K.A: Molecular Genetics of Blood Coagulation. Thrombosis and Hemorrhage, 3rd Edition. Loscalzo, J. and Schafer, A.I. (eds.). Lippincott Williams and Wilkins, Philadelphia, PA. Chapter 2: 22-34, 2003.