Physicians and researchers from the Pediatric Sepsis Program at Children's Hospital of Philadelphia are regular contributors to clinical publications and frequent speakers at national conferences. Here, we highlight some of their publications, abstracts and presentations.

Publications

2022

Yehya N, Fitzgerald JC, Hayes K, et al. Temperature Trajectory Sub-phenotypes and the Immuno-Inflammatory Response in Pediatric Sepsis. Shock 2022;57:645-51.

Woods-Hill CZ, Xie A, Lin J, et al. Numbers and narratives: how qualitative methods can strengthen the science of paediatric antimicrobial stewardship. JAC Antimicrob Resist 2022;4:dlab195.

Woods-Hill CZ, Colantuoni EA, Koontz DW, et al. Association of Diagnostic Stewardship for Blood Cultures in Critically Ill Children With Culture Rates, Antibiotic Use, and Patient Outcomes: Results of the Bright STAR Collaborative. JAMA Pediatr 2022.

Weiss SL, Carcillo JA, Leclerc F, et al. Refining the Pediatric Multiple Organ Dysfunction Syndrome. Pediatrics 2022;149:S13-S22.

Weber MD, Conlon T, Woods-Hill C, et al. Retrospective Assessment of Patient and Catheter Characteristics Associated With Malpositioned Central Venous Catheters in Pediatric Patients. Pediatr Crit Care Med 2022;23:192-200.

Wang Z, Moresco P, Yan R, et al. Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack. Proc Natl Acad Sci U S A 2022;119.

Tsukahara K, Lindell RB, Newman H, Lerman BJ, Kersun LS, Piccione J. Successful whole lung lavage in a child with pulmonary alveolar proteinosis secondary to hematologic malignancy. Pediatr Pulmonol 2022;57:308-10.

Traube C, Tucci M, Nellis ME, et al. Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs. Crit Care Med 2022;50:173-82.

Smida T, Salerno J, Weiss L, Martin-Gill C, Salcido DD. PulsePoint dispatch associated patient characteristics and prehospital outcomes in a mid-sized metropolitan area. Resuscitation 2022;170:36-43.

Sick-Samuels AC, Woods-Hill C. Diagnostic Stewardship in the Pediatric Intensive Care Unit. Infect Dis Clin North Am 2022;36:203-18.

Rhine MA, Hegermiller EM, Kane JM, et al. Mortality and PICU Hospitalization Among Pediatric Gunshot Wound Victims in Chicago. Crit Care Explor 2022;4:e0626.

Periasamy U, Chilutti M, Kaplan SL, et al. Prevalence of and Associations With Avascular Necrosis After Pediatric Sepsis: A Single-Center Retrospective Study. Pediatr Crit Care Med 2022;23:e153-e61.

Olson V, Chang IJ, Merritt Nd JL, Mingbunjerdsuk D. Refractory Myoclonus as a Presentation of Metabolic Stroke in A Child With Cobalamin B Methylmalonic Acidemia After Liver and Kidney Transplant. J Mov Disord 2022.

Isserman RS, Cheung J, Varallo D, et al. Increasing Cefazolin Use for Perioperative Antibiotic Prophylaxis in Penicillin-Allergic Children. Pediatrics 2022;149.

Hobbs CV, Woodworth K, Young CC, et al. Frequency, Characteristics and Complications of COVID-19 in Hospitalized Infants. Pediatr Infect Dis J 2022;41:e81-e6.

Grant DS, Neville DN, Levas M, et al. Validation of Septic Knee Monoarthritis Prediction Rule in a Lyme Disease Endemic Area. Pediatr Emerg Care 2022;38:e881-e5.

Federico L, McGrail DJ, Bentebibel SE, et al. Distinct tumor-infiltrating lymphocyte landscapes are associated with clinical outcomes in localized non-small-cell lung cancer. Ann Oncol 2022;33:42-56.

Chiotos K, Fitzgerald JC, Hayes M, et al. Improving Vancomycin Stewardship in Critically Ill Children. Pediatrics 2022;149.

Burkova VN, Butovskaya ML, Randall AK, et al. Factors Associated With Highest Symptoms of Anxiety During COVID-19: Cross-Cultural Study of 23 Countries. Front Psychol 2022;13:805586.

Bhalala US, Gist KM, Tripathi S, et al. Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry. Crit Care Med 2022;50:e40-e51.

Becker AE, Teixeira SR, Lunig NA, et al. Sepsis-Related Brain MRI Abnormalities Are Associated With Mortality and Poor Neurological Outcome in Pediatric Sepsis. Pediatr Neurol 2022;128:1-8.

2021

Yehya N. Assessment of the Temporal Trajectory of Clinical Trials for COVID-19 Interventions After Highly Publicized Lay and Medical Attention. JAMA Netw Open 2021;4:e210689

Yan M, Toh TS, Lindsay PE, et al. Limited-stage small cell lung cancer: Outcomes associated with prophylactic cranial irradiation over a 20-year period at the Princess Margaret Cancer Centre. Clin Transl Radiat Oncol 2021;30:43-9.

Woods-Hill CZ, Papili K, Nelson E, et al. Harnessing implementation science to optimize harm prevention in critically ill children: A pilot study of bedside nurse CLABSI bundle performance in the pediatric intensive care unit. Am J Infect Control 2021;49:345-51.

Woods-Hill CZ, Koontz DW, Voskertchian A, et al. Consensus Recommendations for Blood Culture Use in Critically Ill Children Using a Modified Delphi Approach. Pediatr Crit Care Med 2021;22:774-84.

Wolf J, Abzug MJ, Wattier RL, et al. Initial Guidance on Use of Monoclonal Antibody Therapy for Treatment of Coronavirus Disease 2019 in Children and Adolescents. J Pediatric Infect Dis Soc 2021;10:629-34.

Wolf J, Abzug MJ, Wattier RL, et al. Initial Guidance on Use of Monoclonal Antibody Therapy for Treatment of COVID-19 in Children and Adolescents. J Pediatric Infect Dis Soc 2021.

Wimmer S, Deloch L, Hader M, et al. Hypofractionated Radiotherapy Upregulates Several Immune Checkpoint Molecules in Head and Neck Squamous Cell Carcinoma Cells Independently of the HPV Status While ICOS-L Is Upregulated Only on HPV-Positive Cells. Int J Mol Sci 2021;22.

Willems A, Tapley A, Fielding A, et al. Prevalence and Associations of General Practice Registrars' Management of Atopic Dermatitis: A Cross-Sectional Analysis from the Registrar Clinical Encounters in Training Study. Dermatol Pract Concept 2021;11:e2021128.

Weiss SL, Henrickson SE, Lindell RB, et al. Influence of Immune Cell Subtypes on Mitochondrial Measurements in Peripheral Blood Mononuclear Cells From Children With Sepsis. Shock 2021.

Weiss SL, Bittinger K, Lee JJ, et al. Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function. Crit Care Explor 2021;3:e0360.

Weiss SL, Balamuth F, Long E, et al. PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial. Trials 2021;22:776.

Wang ME, Neuman MI, Nigrovic LE, et al. Characteristics of Afebrile Infants =60 Days of Age With Invasive Bacterial Infections. Hosp Pediatr 2021;11:100-5.

Tripathi S, Christison AL, Levy E, et al. The Impact of Obesity on Disease Severity and Outcomes Among Hospitalized Children With COVID-19. Hosp Pediatr 2021;11:e297-e316.

Traube C, Gerber LM, Mauer EA, et al. Delirium in Children Undergoing Hematopoietic Cell Transplantation: A Multi-Institutional Point Prevalence Study. Front Oncol 2021;11:627726.

Toto RL, Vorel ES, Tay KE, et al. Augmented Reality in Pediatric Septic Shock Simulation: Randomized Controlled Feasibility Trial. JMIR Med Educ 2021;7:e29899.

Tasoulas J, Lenze NR, Farquhar D, et al. The addition of chemotherapy to adjuvant radiation is associated with inferior survival outcomes in intermediate-risk HPV-negative HNSCC. Cancer Med 2021;10:3231-9.

Taghdiri N, Calcagno DM, Fu Z, et al. Macrophage calcium reporter mice reveal immune cell communication in vitro and in vivo. Cell Rep Methods 2021;1.

Sundheim KM, Levas MN, Balamuth F, et al. Seasonality of Acute Lyme Disease in Children. Trop Med Infect Dis 2021;6.

Stanski NL, Wong HR, Basu RK, et al. Recalibration of the Renal Angina Index for Pediatric Septic Shock. Kidney Int Rep 2021;6:1858-67.

Srinivasan L. New (Ab)normal: A Tale of 2 Pandemics. JAMA 2021.

Son MBF, Murray N, Friedman K, et al. Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes. N Engl J Med 2021;385:23-34.

Sen M, Honavar SG, Bansal R, et al. Epidemiology, clinical profile, management, and outcome of COVID-19-associated rhino-orbital-cerebral mucormycosis in 2826 patients in India - Collaborative OPAI-IJO Study on Mucormycosis in COVID-19 (COSMIC), Report 1. Indian J Ophthalmol 2021;69:1670-92.

Sartori LF, Zhu Y, Grijalva CG, et al. Pneumonia Severity in Children: Utility of Procalcitonin in Risk Stratification. Hosp Pediatr 2021;11:215-22.

Sallee CJ, Smith LS, Rowan CM, et al. Early Cumulative Fluid Balance and Outcomes in Pediatric Allogeneic Hematopoietic Cell Transplant Recipients With Acute Respiratory Failure: A Multicenter Study. Front Oncol 2021;11:705602.

Rowan CM, Fitzgerald JC, Agulnik A, et al. Risk Factors for Noninvasive Ventilation Failure in Children Post-Hematopoietic Cell Transplant. Front Oncol 2021;11:653607.

Rhee C, Chiotos K, Cosgrove SE, et al. Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure. Clin Infect Dis 2021;72:541-52.

Reddy A, Jenssen BP, Chidambaram A, Yehya N, Lindell RB. Characterizing e-cigarette vaping-associated lung injury in the pediatric intensive care unit. Pediatr Pulmonol 2021;56:162-70.

Rahman SN, Flores VX, Monaghan TF, Weiss JP. RE: A High Percent Free Prostate Specific Antigen in the Setting of Biochemical Recurrence after Radical Prostatectomy is Associated with Poorer Outcomes: A Validation Study Using Prospectively Collected Biobank Specimens. D. T. S. Woon, J. O. Herrera-Caceres, H. Goldberg, H. Shiakh, E. Whelan, G. Nason, K. Ajib, G. Hee Tan, T. Chandrasekar, O. Alhunaidi, A. Finelli, A. Zlotta, A. Berlin, E. Diamantis and N. Fleshner J Urol 2020; 204: 289-295. J Urol 2021;205:276-7.

Ragoonanan D, Khazal SJ, Abdel-Azim H, et al. Diagnosis, grading and management of toxicities from immunotherapies in children, adolescents and young adults with cancer. Nat Rev Clin Oncol 2021.

Pinto NP, Berg RA, Zuppa AF, et al. Improvement in Health-Related Quality of Life After Community Acquired Pediatric Septic Shock. Front Pediatr 2021;9:675374.

Payne AB, Gilani Z, Godfred-Cato S, et al. Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2. JAMA Netw Open 2021;4:e2116420.

Paul R, Niedner M, Brilli R, et al. Metric Development for the Multicenter Improving Pediatric Sepsis Outcomes (IPSO) Collaborative. Pediatrics 2021;147.

Oved JH, Paris AJ, Gollomp K, et al. Neutrophils promote clearance of nuclear debris following acid-induced lung injury. Blood 2021;137:392-7.

North HF, Weissleder C, Fullerton JM, Sager R, Webster MJ, Weickert CS. A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone. Transl Psychiatry 2021;11:635.

Neville DN, Alexander ME, Bennett JE, et al. Electrocardiogram as a Lyme Disease Screening Test. J Pediatr 2021;238:228-32 e1.

Myers SR, Abbadessa MKF, Gaines S, et al. Repurposing Video Review Infrastructure for Clinical Resuscitation Care in the Age of COVID-19. Ann Emerg Med 2021;77:110-6.

Mody L, Akinboyo IC, Babcock HM, et al. COVID-19 Research Agenda for Healthcare Epidemiology. Infect Control Hosp Epidemiol 2021:1-81.

Mitchell HK, Reddy A, Montoya-Williams D, Harhay M, Fowler JC, Yehya N. Hospital outcomes for children with severe sepsis in the USA by race or ethnicity and insurance status: a population-based, retrospective cohort study. Lancet Child Adolesc Health 2021;5:103-12.

Michelini S, Barbero F, Prinelli A, et al. Gold nanoparticles (AuNPs) impair LPS-driven immune responses by promoting a tolerogenic-like dendritic cell phenotype with altered endosomal structures. Nanoscale 2021;13:7648-66.

Mehta SD, Martin K, McGowan N, et al. Ventilator-Weaning Pathway Associated With Decreased Ventilator Days in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med 2021;49:302-10.

McGann C, Coggins SA, Dysart K. Does a lower interventional glucose threshold affect neurodevelopment in at-risk neonates? J Perinatol 2021.

Malik K, Michelson D, Doyle AM, et al. Effectiveness and costs associated with a lay counselor-delivered, brief problem-solving mental health intervention for adolescents in urban, low-income schools in India: 12-month outcomes of a randomized controlled trial. PLoS Med 2021;18:e1003778.

Mah KE, Alten JA, Cornell TT, et al. Acute kidney injury after in-hospital cardiac arrest. Resuscitation 2021;160:49-58.

Magin P, Quain D, Tapley A, et al. Deprescribing in older patients by early-career general practitioners: Prevalence and associations. Int J Clin Pract 2021;75:e14325.

Lindell RB, Wolf MS, Alcamo AM, et al. Case Report: Immune Dysregulation Due to Toxoplasma gondii Reactivation After Allogeneic Hematopoietic Cell Transplant. Front Pediatr 2021;9:719679.

Lin CY, Xie J, Freedman SB, et al. Predicting Adverse Outcomes for Shiga Toxin-Producing Escherichia coli Infections in Emergency Departments. J Pediatr 2021.

Leonard JC, Josephson CD, Luther JF, et al. Life-Threatening Bleeding in Children: A Prospective Observational Study. Crit Care Med 2021;49:1943-54.

Larsen GY, Brilli R, Macias CG, et al. Development of a Quality Improvement Learning Collaborative to Improve Pediatric Sepsis Outcomes. Pediatrics 2021;147.

LaRovere KL, Riggs BJ, Poussaint TY, et al. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol 2021;78:536-47.

Lantos PM, Balamuth F, Neville D, et al. Two-Tier Lyme Disease Serology in Children with Previous Lyme Disease. Vector Borne Zoonotic Dis 2021;21:839-42.

Kitt EM, Davis DH, Kerman C, et al. The utility of paired upper and lower respiratory tract sampling for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing in patients with artificial airways. Infect Control Hosp Epidemiol 2021:1-3.

Kayisoglu O, Weiss F, Niklas C, et al. Location-specific cell identity rather than exposure to GI microbiota defines many innate immune signaling cascades in the gut epithelium. Gut 2021;70:687-97.

Kadauke S, Myers RM, Li Y, et al. Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial. J Clin Oncol 2021;39:920-30.

Himebauch AS, Wong W, Wang Y, et al. Preoperative echocardiographic parameters predict primary graft dysfunction following pediatric lung transplantation. Pediatr Transplant 2021;25:e13858.

Herold R, Scholtysik R, Moroniak S, et al. Capsule-dependent impact of MAPK signaling on host cell invasion and immune response during infection of the choroid plexus epithelium by Neisseria meningitidis. Fluids Barriers CNS 2021;18:53.

Haschka D, Hoffmann A, Weiss G. Iron in immune cell function and host defense. Semin Cell Dev Biol 2021;115:27-36.

Hafezi-Nejad N, Bailey CR, Solomon AJ, et al. Vertebroplasty and kyphoplasty in the USA from 2004 to 2017: national inpatient trends, regional variations, associated diagnoses, and outcomes. J Neurointerv Surg 2021;13:483-91.

Gupta R, Kesavadev J, Krishnan G, et al. COVID-19 associated mucormycosis: A Descriptive Multisite Study from India. Diabetes Metab Syndr 2021;15:102322.

Geva A, Patel MM, Newhams MM, et al. Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents. E Clinical Medicine 2021;40:101112.

Garro A, Avery RA, Cohn KA, et al. Validation of the Rule of 7's for Identifying Children at Low-risk for Lyme Meningitis. Pediatr Infect Dis J 2021;40:306-9.

Fleiss N, Coggins SA, Lewis AN, et al. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection. JAMA Netw Open 2021;4:e2036518.

Fitzgerald JC, Ross ME, Thomas NJ, et al. Association of early hypotension in pediatric sepsis with development of new or persistent acute kidney injury. Pediatr Nephrol 2021;36:451-61.

Fitzgerald JC, Kelly NA, Hickey C, et al. Implementation of a Follow-Up System for Pediatric Sepsis Survivors in a Large Academic Pediatric Intensive Care Unit. Front Pediatr 2021;9:691692.

Fisher BT, Sharova A, Boge CLK, et al. Evolution of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence among employees of a US academic children's hospital during coronavirus disease 2019 (COVID-19) pandemic. Infect Control Hosp Epidemiol 2021:1-9.

Feldstein LR, Tenforde MW, Friedman KG, et al. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA 2021;325:1074-87.

Diorio C, Shraim R, Vella LA, et al. Proteomic Profiling of MIS-C Patients Reveals Heterogeneity Relating to Interferon Gamma Dysregulation and Vascular Endothelial Dysfunction. medRxiv 2021.

Cruz AT, Nigrovic LE, Xie J, et al. Predictors of Invasive Herpes Simplex Virus Infection in Young Infants. Pediatrics 2021;148.

Coggins SA, Laskin B, Harris MC, et al. Acute Kidney Injury Associated with Late-Onset Neonatal Sepsis: A Matched Cohort Study. J Pediatr 2021;231:185-92 e4.

Chiotos K, Weiss SL. A Wrinkle in Time to Antibiotics in Sepsis: When Should ONE Hour Be the Goal? J Pediatr 2021.

Chiotos K, Hayes M, Kimberlin DW, et al. Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2. J Pediatric Infect Dis Soc 2021;10:34-48.

Cascone T, Weissferdt A, Godoy MCB, et al. Nodal immune flare mimics nodal disease progression following neoadjuvant immune checkpoint inhibitors in non-small cell lung cancer. Nat Commun 2021;12:5045.

Butler AD, Dominick CL, Yehya N. High frequency percussive ventilation in pediatric acute respiratory failure. Pediatr Pulmonol 2021;56:502-8.

Blick C, Vinograd A, Chung J, et al. Procedural competency for ultrasound-guided peripheral intravenous catheter insertion for nurses in a pediatric emergency department. J Vasc Access 2021;22:232-7.

Blatz AM, Oboite M, Chiotos K, Castelo-Soccio L, Odom John AR, Children's Hospital of Philadelphia MISCRC. Cutaneous Findings in SARS-CoV-2-Associated Multisystem Inflammatory Disease in Children. Open Forum Infect Dis 2021;8:ofab074.

Blache U, Weiss R, Boldt A, et al. Advanced Flow Cytometry Assays for Immune Monitoring of CAR-T Cell Applications. Front Immunol 2021;12:658314.

Bjornstad EC, Krallman KA, Askenazi D, et al. Preliminary Assessment of Acute Kidney Injury in Critically Ill Children Associated with SARS-CoV-2 Infection: A Multicenter Cross-Sectional Analysis. Clin J Am Soc Nephrol 2021;16:446-8.

Bera OP, Saleem SM, Singh DK, et al. Optimizing the impact of health and related programmes / policies to address the issue of Childhood Obesity in India----A narrative review. J Family Med Prim Care 2021;10:1554-61.

Becker AE, Chiotos K, McGuire JL, Bruins BB, Alcamo AM. Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children. J Pediatr 2021;233:263-7

Balasubramanian H, Atyalgade M, Garg B, Srinivasan L, Kabra NS, Khapekar S. Effects of blood sampling stewardship and erythropoietin administration in extremely low birth weight infants-a quality improvement non-controlled before-and-after retrospective study. Eur J Pediatr 2021;180:1617-26.

Arnoldi S, Glau CL, Walker SB, et al. Integrating Focused Cardiac Ultrasound Into Pediatric Septic Shock Assessment. Pediatr Crit Care Med 2021;22:262-74.

Alcamo AM, Lavezoli R, Dezfulian C, et al. Feasibility and Performance of a Gel-Adhesive Pad System for Pediatric Targeted Temperature Management: An Exploratory Analysis of 19 Pediatric Critically Ill Patients. Ther Hypothermia Temp Manag 2021;11:19-27.

Abulebda K, Whitfill T, Montgomery EE, et al. Improving Pediatric Readiness in General Emergency Departments: A Prospective Interventional Study. J Pediatr 2021;230:230-7 e1.

2020

Abbadessa MK. Call to Action: The Need for Best Practice for Boarding the Pediatric Intensive Care Patient in the Emergency Department Journal of Emergency Nursing. 2020. Mar; 46(2):150-153. Epub 2020 Jan 23. PMID 31983462.

Balamuth F, Alpern ER, Kan M, et al. Gene Expression Profiles in Children With Suspected Sepsis. Ann Emerg Med. 2020 Jun; 75(6):744-754. Epub 2020 Jan 23. PMID: 31983492.

Cavallin F, Rubin G, Vidal E, et al. Prognostic role of acute kidney injury on long-term outcome in infants with hypoxic-ischemic encephalopathy. Pediatr Nephrol. 2020;35(3):477-483. 2020 Mar;35(3):477-483. Epub 2019 Dec 11. PMID: 31828471.

Coggins S, Harris MC, Grundmeier R, Kalb E, Nawab U, Srinivasan L. Performance of Pediatric Systemic Inflammatory Response Syndrome and Organ Dysfunction Criteria in Late-Onset Sepsis in a Quaternary Neonatal Intensive Care Unit: A Case-Control Study. J Pediatr. 2020 Apr; 219:133-139.e1. Epub 2020 Feb 6. PMID: 32037153.

Downes KJ, Hayes M, Fitzgerald JC, et al. Mechanisms of antimicrobial-induced nephrotoxicity in children. J Antimicrob Chemother. 2020;75(1):1-13. 2020 Jan 1; 75(1):1-13. PMID: 31369087.

Fesnak S, Abbadessa MK, Hayes K, et al. Sepsis in Complex Patients in the Emergency Department: Time to Recognition and Therapy in Pediatric Patients With High-Risk Conditions. Pediatr Emerg Care. 2020;36(2):63-65. 2020 Feb; 36(2):63-65. PMID: 31929394.

Fuhrman DY, Kellum JA, Joyce EL, et al. The use of urinary biomarkers to predict acute kidney injury in children after liver transplant. Pediatr Transplant. 2020;24(1):e13608. 2020 Feb;24(1):e13608. Epub 2019 Oct 25. PMID: 31652022.

Fujii T, Luethi N, Young PJ, et al. Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial. JAMA. 2020 Jan 17; 323(5):423-431.  Online ahead of print. PMID: 31950979.

Gordon SM, Srinivasan L, Taylor DM, et al. Derivation of a metabolic signature associated with bacterial meningitis in infants. Pediatr Res. 2020. Pediatr Res. 2020 Mar 2. Online ahead of print. PMID: 32120377.

Himebauch AS, Yehya N, Wang Y, McGowan FX, Mercer-Rosa L. New or Persistent Right Ventricular Systolic Dysfunction Is Associated With Worse Outcomes in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2020;21(2):e121-e128.

Moffet JR, Mahadeo KM, McArthur J, et al. Acute respiratory failure and the kinetics of neutrophil recovery in pediatric hematopoietic cell transplantation: a multicenter study. Bone Marrow Transplant. 2020;(2):341-348. 2020 Feb; 21(2):e121-e128.  PMID: 31851127.

Nigrovic LE, Bennett JE, Balamuth F, et al. Diagnostic Performance of C6 Enzyme Immunoassay for Lyme Arthritis. Pediatrics. 2020;145(1). PMID: 3186615.

Novak T, Hall MW, McDonald DR, et al. RIG-I and TLR4 Responses and Adverse Outcomes in Pediatric Influenza-Related Critical Illness. J Allergy Clin Immunol. 2020. Jun; 145(6):1673-1680.e11.  Epub 2020 Feb 6. PMID: 32035159.

Pais GM, Liu J, Avedissian SN, et al. Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model. J Antimicrob Chemother. 2020. May 1; 75(5):1228-1236. PMID: 32011685.

Schmatz M, Srinivasan L, Grundmeier RW, et al. Surviving Sepsis in a Referral Neonatal Intensive Care Unit: Association between Time to Antibiotic Administration and In Hospital Outcomes. J Pediatr. 2020;217:59-65 e51. 2020 Feb; 217:59-65.e1. Epub 2019 Oct 8. PMID: 31604632.

Stanski NL, Cvijanovich NZ, Fitzgerald JC, Bigham MT, Wong HR, Genomics of Pediatric Septic Shock I. Severe acute kidney injury is independently associated with mortality in children with septic shock. Intensive Care Med. 2020 May;46(5):1050-1051.  Epub 2020 Feb 11. PMID: 32047942.

Stanski NL, Stenson EK, Cvijanovich NZ, et al. PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock. Am J Respir Crit Care Med. 2020 Apr 1; 201(7):848-855. PMID: 31916857.

Ueno K, Shiokawa N, Takahashi Y, et al. Kidney Disease: Improving Global Outcomes in neonates with acute kidney injury after cardiac surgery. Clin Exp Nephrol. 2020;24(2):167-173. PMID: 29891225.

Wald EL, Sanchez-Pinto LN, Smith CM, et al. Hydrocortisone-Ascorbic Acid-Thiamine Use Associated with Lower Mortality in Pediatric Septic Shock. Am J Respir Crit Care Med. 2020. Apr 1; 201(7):863-867.  PMID: 31916841.

Weiss SL, Balamuth F, Chilutti M, et al. Identification of Pediatric Sepsis for Epidemiologic Surveillance Using Electronic Clinical Data. Pediatr Crit Care Med. 2020;21(2):113-121. PMID: 32032262.

Weiss SL, Peters MJ, Alhazzani W, et al. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020;21(2):e52-e106. PMID: 32032273.

Weiss SL, Peters MJ, Alhazzani W, et al. Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020;21(2):186-195. PMID: 32032264.

Whitney JE, Zhang B, Koterba N, et al. Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis. Crit Care Med. 2020;48(3):344-352. PMID: 32058372.

Woods-Hill CZ, Koontz DW, King AF, et al. Practices, Perceptions, and Attitudes in the Evaluation of Critically Ill Children for Bacteremia: A National Survey. Pediatr Crit Care Med. 2020;21(1):e23-e29. PMID: 31702704.

Woods-Hill CZ, Srinivasan L, Schriver E, Haj-Hassan T, Bezpalko O, Sammons JS. Novel risk factors for central-line associated bloodstream infections in critically ill children. Infect Control Hosp Epidemiol. 2020;41(1):67-72. PMID: 31685049.

Zinter MS, Logan BR, Fretham C, et al. Comprehensive Prognostication in Critically Ill Pediatric Hematopoietic Cell Transplant Patients: Results from Merging the Center for International Blood and Marrow Transplant Research (CIBMTR) and Virtual Pediatric Systems (VPS) Registries. Biol Blood Marrow Transplant. 2020;26(2):333-342. PMID: 31563573.

2019

Fitzgerald JC, Zane NR, Himebauch AS, Reedy MD, Downes KJ, Topjian AA, Furth SL, Thomas NJ, Scheetz MH, Zuppa AF: Vancomycin prescribing and therapeutic drug monitoring in children with and without acute kidney injury after cardiac arrest. Pediatric Drugs 2019 Apr; 21(2):107-112. PMID: 30864056.

Randolph AG, Xu R, Novak T, Newhams MM, Bubeck Wardenburg J, Weiss SL, Sanders RC, Thomas NJ, Hall MW, Tarquinio KM, Cvijanovich N, Gedeit RG, Truemper EJ, Markovitz B, Hartman ME, Ackerman KG, Giuliano JS Jr, Shein SL, Moffitt KL for the Pediatric Intensive Care Influenza Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators Network. Vancomycin monotherapy bay be insufficient to treat methicillin-resistant staphylococcus aureus coinfection in children with influenza-related critical illness. Clinical Infectious Diseases 2019 (3):365-372.

Pais GM, Avedissian SN, O'Donnell JN, Rhodes NJ, Lodise TP, Prozialeck WC, Lamar PC, Cluff C, Gulati A, Fitzgerald JC, Downes KJ, Zuppa AF, Scheetz MH: Comparative performance of urinary biomarkers for vancomycin induced kidney injury according to timeline of injury. Antimicrob Agents Chemotherapy. 2019 Jun 24; 63(7):e00079-19. Print 2019 Jul. PMID: 30988153.

Weiss SL, Balamuth F, Thurm CW, Downes KJ, Fitzgerald JC, Laskin BL. Major Adverse Kidney Events in Pediatric Sepsis. Clinical Journal of American Society of Nephrology 2019; doi: 10.2215/CJN.12201018. 2019 May 7; 14(5):664-672. Epub 2019 Apr 18. PMID: 31000518.

Thakkar RK, Weiss SL, Fitzgerald JC, Thomas NJ, Nadkarni VM, Muszynski JA. Hall MW for the SPROUT Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Risk factors for mortality in pediatric post-surgical versus medical severe sepsis. Journal of Surgical Research 2019 Oct; 242:100-110.  Epub 2019 May 7. PMID: 31075654.

Saffaran S, Das A, Hardman JG, Yehya N, Bates DG: High-fidelity computational simulation to refine strategies for lung protective ventilation in paediatric acute respiratory distress syndrome. Intensive Care Med 2019 Jul; 45(7):1055-1057.  Epub 2019 Feb 14. PMID: 30762080.

Levy ER, Yip W, Super M, Ferdinands JN, Anushay M, Su HC, Zhang Y, McLaughlin G, Sapru A, Loftis L, Weiss SL, Hall MW, Cvijanovich N, Schwarz A, Tarquinio K, Randolph A for for the PALISI Pediatric Intensive Care Influenza (PICFLU) Investigators. Mannose binding lectin is associated with pediatric influenza-related critical illness susceptibility and mortality. Submitted to Clinical Infectious Diseases 2019.

Levy E, Yip W, Super M, Ferdinands J, Mistry AJ, Newhams MN, Zhang Y, Su HC, McLaughlin GE, Sapru A, Loftis LL, Weiss SL, Hall MW, Cvijanovich N, Schwarz A, Tarquinio KM, Mourani PM, Randolph AG. Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness. Frontiers Immunology 2019, In Press. 2019 May 8; 10:1005. eCollection 2019. PMID: 31139182.

Gollomp K, Poncz M. Gp1ba-Cre or Pf4-Cre: pick your poison. Blood. 2019 (4):287-288.[PMID30679234]

Weiss SL, Zhang D, Bush J, Graham K, Starr J, Tuluc F, Henrickson S, Kilbaugh T, Deutschman CS, Murdock D, McGowan FX, Becker L, Wallace DC. Persistent mitochondrial dysfunction linked to prolonged organ dysfunction in pediatric sepsis. Submitted to Critical Care Medicine. 2019 Oct; 47(10):1433-1441. PMID: 31385882.

Matehuala S, Pasala S, Goudie A, Fiser R, Weiss SL, Irby K, Crary S, Wang A, Sanders R. Red blood cell distribution width values are associated with multiorgan dysfunction and outcomes in children admitted to the pediatric intensive care unit. Submitted to Intensive Care Medicine 2019.

Han M, Roberts AL, Migliore BA, Cardenas AM, Weiss SL. Reactivation viremia in pediatric sepsis. Submitted to Pediatric Critical Care Medicine 2019. 2020 Apr; 21(4):e152-e159. PMID: 31725532.

Weiss SL, Blowey B, Keele L, Ganetskey R, Murali CN, Fitzgerald JC, Sutton RM, Berg RA. Matched retrospective cohort study of thiamine to treat persistent hyperlactatemia in pediatric septic shock. Submitted to Pediatric Critical Care Medicine 2019. 2019 Sep; 20(9):e452-e456. PMID: 31274776.

Glau CL, Conlon TW, Himebauch AS, Yehya N, Weiss SL, Berg RA, Nishisaki A. Diaphragm atrophy during pediatric acute respiratory failure is associated with prolonged noninvasive ventilation requirement following extubation. Submitted to Pediatric Critical Care Medicine 2019. 2020 May 20. Online ahead of print. PMID: 32433439.

Balamuth F, Kittick M, McBride P, Woodford AL, Vestal N, Casper TC, Metheney M, Smith K, Atkin NK, Baren J, Dean JM, Kuppermann N, Weiss SL. Pragmatic pediatric trial of balanced versus normal saline fluid in sepsis: the PRoMPT BOLUS pilot feasibility study. Submitted to Academic Emergency Medicine. 2019 Dec; 26(12):1346-1356. Epub 2019 Jul 18. PMID: 31183919.

Lockman JL, Yehya N, Schwartz AJ, Cronholm PF: Professionalism in Pediatric Anesthesiology: Affirmation of a definition based on results of a nationally-administered survey of pediatric anesthesiologists. Paediatr Anaesth 29(4): 345-352, Apr 2019. PMID: 30710425.

Schlapbach LJ, Weiss SL, Wolf J. Primum non nocere:  Reducing Collateral Damage from Mandates for Time to Antibiotics. JAMA Pediatrics. doi: 10.1001/jamapediatrics.2019.0174. [Epub ahead of print] 2019 May 1; 173(5):409-410. PMID: 30882879.

Weiss SL, Babl FE, Dalziel SR, Balamuth F. Is chloride worth its salt? [Invited editorial]. Intensive Care Medicine 2019; (2):275-277. PMID: 30488168.

Imber DA, Thomas NJ, Yehya N: Association between tidal volumes adjusted for ideal body weight and outcomes in pediatric acute respiratory distress syndrome. Pediatr Crit Care Med 20(3): e145-e153, Mar 2019; 20(3):e145-e153. PMID: 30640889.

Maulden Alexandra B, Garro Aris C, Balamuth Fran, Levas Michael N, Bennett Jonathan E, Neville Desiree N, Branda John A, Nigrovic Lise E: Two-Tier Lyme Disease Serology Test Results Can Vary According to the Specific First-Tier Test Used. Journal of the Pediatric Infectious Diseases Society 2020. Apr 30; 9(2):128-133. PMID: 30793167.

Yehya N, Thomas NJ, Wong HR: Evidence of endotypes in pediatric acute hypoxemic respiratory failure caused by sepsis. Pediatr Crit Care Med 20(2): 110-112, Feb 2019. PMID: 30720645.

Masino Aaron J, Harris Mary Catherine, Forsyth Daniel, Ostapenko Svetlana, Srinivasan Lakshmi, Bonafide Christopher P, Balamuth Fran, Schmatz Melissa, Grundmeier Robert W: Machine learning models for early sepsis recognition in the neonatal intensive care unit using readily available electronic health record data. PloS one. 2019 Feb 22; 14(2):e0212665. PMID: 30794638.

Lindell Robert B, Nishisaki Akira, Weiss Scott L, Balamuth Fran, Traynor Danielle M, Chilutti Marianne R, Grundmeier Robert W, Fitzgerald Julie C: Comparison of Methods for Identification of Pediatric Severe Sepsis and Septic Shock in the Virtual Pediatric Systems Database. Critical care medicine 47(2): e129-e135, Feb 2019. PMCID: PMC6336511

Yehya N, Song MJ, Lawrence GG, Margulies SS: HER2 Signaling Implicated in Regulating Alveolar Epithelial Permeability with Cyclic Stretch. Int J Mol Sci 20(4): E948, Feb 2019.

Khemani RG, Smith L, Lopez-Fernandez YM, Kwok J, Morzov R, Klein MJ, Yehya N, Willson D, Kneyber MCJ, Lillie J, Fernandez A, Newth CJL, Jouvet P, Thomas NJ: Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study. Lancet Respir Med 7(2): 115-128, Feb 2019.

Masino AJ, Harris MC, Forsyth D, Ostapenko S, Srinivasan L, Bonafide CP, Balamuth F, Schmatz M, Grundmeier RW. Machine learning models for early sepsis recognition in the neonatal intensive care unit using readily available electronic health record data. PLoS One. 2019 Feb 22; 14(2):e0212665. doi: 10.1371/journal.pone.0212665. eCollection 2019. PMID: 30794638

Pruitt Christopher M, Neuman Mark I, Shah Samir S, Shabanova Veronika, Woll Christopher, Wang Marie E, Alpern Elizabeth R, Williams Derek J, Sartori Laura, Desai Sanyukta, Leazer Rianna C, Marble Richard D, McCulloh Russell J, DePorre Adrienne G, Rooholamini Sahar N, Lumb Catherine E, Balamuth Fran, Shin Sarah, Aronson Paul L: Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections. The Journal of pediatrics 204: 177-182.e1, Jan 2019. PMCID: PMC6309646

Mahadeo K, Khazal S, Abdel-Azim H, Fitzgerald JC, Taraseviciute A, Bollard C, Tewari P, Duncan C, Traube C, McCall D, Steiner M, Cheifetz I, Lehmann L, Mejia R, Slopis J, Bajwa R, Kebriaei P, Martin P, Moffet J, McArthur J, Petropoulos D, Curry JO, Featherston S, Foglesong J, Shoberu B, Glubis A, Mireles M, Hafemeister L, Nguyen C, Kapoor N, Rezvani K, Neelapu SS, Shpall E, PALISI Network: Guidelines for Chimeric Antigen Recepter T-Cell (CAR-T) therapy management of pediatric patients. Nat Rev Clin Oncol 16(1): 45-63, January 2019.

Yehya N, Thomas NJ: Sepsis and Pediatric Acute Respiratory Distress Syndrome. J Pediatr Intensive Care 8(1): 32-41, Jan 2019.

2018

Thomson Joanna, Sucharew Heidi, Cruz Andrea T, Nigrovic Lise E, Freedman Stephen B, Garro Aris C, Balamuth Fran, Mistry Rakesh D, Arms Joseph L, Ishimine Paul T, Kulik Dina M, Neuman Mark I, Shah Samir S: Cerebrospinal Fluid Reference Values for Young Infants Undergoing Lumbar Puncture. Pediatrics Page:  doi: 10.1542, February 2018 Notes: epub ahead of print.

Aronson Paul L, Wang Marie E, Shapiro Eugene D, Shah Samir S, DePorre Adrienne G, McCulloh Russell J, Pruitt Christopher M, Desai Sanyukta, Nigrovic Lise E, Marble Richard D, Leazer Rianna C, Rooholamini Sahar N, Sartori Laura F, Balamuth Fran, Woll Christopher, Neuman Mark I: Risk Stratification of Febrile Infants u880460 Days Old Without Routine Lumbar Puncture. Pediatrics 142(6), Dec 2018. PMCID: PMC6317769

Nigrovic Lise E, Lipsett Susan C, Molins Claudia R, Wormser Gary P, Bennett Jonathan E, Garro Aris C, Levas Michael N, Balamuth Fran, Neville Desiree, Lingampalli Nithya, Robinson William H, Branda John A: Higher C6 enzyme immunoassay index values correlate with a diagnosis of noncutaneous Lyme disease. Diagnostic microbiology and infectious disease Dec 2018.

Balamuth M.D. PhD MSCE,1 Andrea T. Cruz M.D. M.P.H.,2 Stephen B. Freedman M.D. M.P.H.,3 Paul T. Ishimine M.D.,4 Aris C. Garro M.D. M.P.H.,5 Sarah Curtis M.D.,6 Kendra L. Grether-Jones M.D.,7 Aaron S. Miller M.D. M.P.H.,8 Neil G. Uspal M.D.,9 Suzanne M. Schmidt M.D.,10 Samir S. Shah M.D. M.P.H.,11 Lise E. Nigrovic M.D. M.P.H.12 for the Pediatric Emergency Medicine Collaborative Research Committee (PEM CRC) HSV Study Group.  : Test Characteristics of cerebrospinal fluid Gram stain to identify bacterial meningitis in infants less than 60 days old. Pediatric Emergency Care 204: 177-182, November 2018.

Himebauch AS, Yehya N, Yan W, Conlon TW, Kilbuagh TJ, McGowan FX, Mercer-Rosa L: Early right ventricular systolic dysfunction and pulmonary hypertension are associated with worse outcomes in pediatric acute respiratory distress syndrome. Crit Care Med 46(11): e1055-e1062, Nov 2018.

Keim G, Watson RS, Thomas NJ, Yehya N: New morbidity and discharge disposition of pediatric acute respiratory distress syndrome survivors. Crit Care Med 46(11): 1731-1738, Nov 2018.

Gollomp K, Kim M, Johnston I, Hayes V, Welsh JD, Arepally GW, Kahn ML, Lambert MP, Cuker A, Cines DB, Rauova L, Kowalska AM, Poncz M. Neutrophil accumulation and NET release contribute to thrombosis in HIT. JCI Insight 2018;3(18).pii:99446 [PMID30232279]

Dowell JC, Parvathaneni K, Thomas NJ, Khemani RG, Yehya N: Epidemiology of cause of death in pediatric acute respiratory distress syndrome. Crit Care Med 46(11): 1811-1819, Nov 2018.

Bhalla AK, Yehya N, Mack WJ, Wilson ML, Khemani RG, Newth CJL: The Association Between Inhaled Nitric Oxide Treatment and ICU Mortality and 28-Day Ventilator-Free Days in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med 46(11): 1803-1810, Nov 2018.

Pruitt CM, Neuman MI, Shah SS, Shabanova V, Woll C, Wang ME, Alpern ER, Williams DJ, Sartori L, Desai S, Leazer RC, Marble RD, McCulloh RJ, DePorre AG, Rooholamini SN, Lumb CE, Balamuth F, Shin SS, Aronson PL for the Febrile Young Infant Research Collaborative: Factors associated with adverse outcomes among febrile young infants with invasive bacterial infections. Journal of Pediatrics 204:177- doi: 10.1016, October 2018.

Rowan CM, McArthur J, Hsing DD, Gertz SJ, Smith LS, Loomis A, Fitzgerald JC, Nitu ME, Moser EAS, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Tamburro RF, Cheifetz IM; Investigators of the Pediatric Acute Lung Injury and Sepsis Network: Acute respiratory failure in pediatric hematopoietic cell transplantation - A Multicenter Study. Critical Care Medicine 46(10): e967-e974, October 2018.

Cornell TT, Selewski DT, Alten JA, Askenazi D, Fitzgerald JC, Topjian AA, Holubkov R, Page K, Slomine BS, Christensen JR, Dean JM, Moler FW: Acute kidney injury after out of hospital pediatric cardiac arrest. Resuscitation 131: 63-38, October 2018.

Christopher Wall, Mark Neuman, Christopher Pruitt, Marie Wang, Eugene Shapiro, Samir Shah, Russell McCulloh, Lise Nigrovic, Sanyukta Desai, Adrienne DePorre, Rianna Leazer, Richard Marble, Frances Balamuth, Elana Feldman, Laura Sartori, Whitney Browning, Paul Aronson: Epidemiology and Etiology of Invasive Bacterial Infection in Infants u880460 Days Old Treated in Emergency Departments. Journal of Pediatrics 200(2): 210-217, September 2018.

Gollomp K, Friedman D, Poncz M. Platelets can soak it up and then spit it out: Lessons for a novel therapy in TTP and beyond. Athero Thromb Vasc Biol. 2018;38(11):2544-2545. [PMID30354233]

Stenson EK, Cvijanovich NZ, Anas N, Allen GL, MD, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak N, Raj SS, Gertz S, Grunwell JR, Wong HR.  Hyperchloremia is associated with complicated course and mortality in pediatric patients with septic shock. Pediatric Critical Care Medicine 2018:19(2):155-160.

Yehya N, Keim G, Thomas NJ: Subtypes of pediatric acute respiratory distress syndrome have different predictors of mortality. Intensive Care Med 44(8): 1230-1239, Aug 2018.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Lindsell CJ. Endotype transitions during the acute phase of pediatric septic shock reflect changing risk and treatment response. Critical Care Medicine 2018:46(3):e242-e249.

Michelson KN, Reubenson G, Weiss SL, Fitzgerald JC, Ackerman K, Christie L, Bush JL, Nadkarni VM, Thomas NJ, Schreiner MS for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Site variability in regulatory oversight for an international study of pediatric sepsis.  Pediatric Critical Care Medicine 2018;19(4):e180-e188.

Khemani RG, Parvathaneni K, Yehya N, Bhalla AK, Thomas NJ, Newth CJL: PEEP Lower Than the ARDS Network Protocol is Associated with Higher Pediatric ARDS Mortality. Am J Respir Crit Care Med 198(1): 77-89, Jul 2018.

Garro A, Bennett J, Balamuth F, Levas MN, Neville D, Branda JC, Maulden AB, Lantos PM, Nigrovic LE for the Pedi Lyme Net. : Positive Two-tiered Lyme Disease Serology is Uncommon in Asymptomatic Children Living in Endemic Areas of the U.S. Pediatric Infectious Disease Journal Page: doi: 10.1097, July 2018 Notes: epub ahead of print.

Carrie Daymont, Fran Balamuth, Halden Scott, Patrick Brady, Chris Bonafide, Holly Depinet, and Elizabeth Alpern: Elevated heart rate and risk of revisit with admission in pediatric emergency patients. Pediatric Emergency Care Page: e-pub ahead of print, July 2018.

Stewart CA, Yehya N, Fei L, Chima RS: High frequency oscillatory ventilation in a cohort of children with respiratory failure. Pediatr Pulmonol 53(6): 816-823, Jun 2018.

Glau DL, Conlon TW, Himebauch AS, Yehya N, Weiss SL, Berg RA, Nishisaki A. Progressive diaphragm atrophy in pediatric acute respiratory failure. Pediatric Critical Care Medicine 2018;19(5):406-411.

Fitzgerald JC, Li Y, Fisher BT, Huang YS, Miller TP, Bagatell R, Seif AE, Aplenc R, Thomas NJ: Hospital variation in intensive care resource utilization and mortality in newly diagnosed pediatric leukemia. Pediatric Critical Care 19(6): e312-e320, June 2018.

Aronson Paul L, McCulloh Russell J, Tieder Joel S, Nigrovic Lise E, Leazer Rianna C, Alpern Elizabeth R, Feldman Elana A, Balamuth Fran, Browning Whitney L, Neuman Mark I: Application of the Rochester Criteria to Identify Febrile Infants With Bacteremia and Meningitis. Pediatric emergency care Page: doi: 10.1097, February 2018 Notes: epub ahead of print.

Aronson PL, Wang ME, Nigrovic LE, Shah SS, Desai S, Pruitt CM, Balamuth F, Sartori L, Marble RD, Rooholamini SN, Leazer RC, Woll C, DePorre AG, Neuman MI; for the Febrile Young Infant Research Collaborative. : Time to pathogen detection for non-ill vs. ill-appearing infants u880460 days old with bacteremia and meningitis. Hospital Pediatrics 8(7): 379-384, July 2018.

Ross RK, Keele K, Kubis S, Lautz AJ, Dziorny AC, Denson AR, O’Connor KA, Chilutti MR, Weiss SL, Gerber JS. Effect of the procalcitonin assay on antibiotic use in critically ill children. Journal of the Pediatric Infectious Diseases Society 2018;7)2):e43-e46.

Nelson CE, Ostapenko S, Zorc JJ, Balamuth F.: Utilization of Antipyretics for Non-urgent Fever in a Pediatric Emergency Department. Clinical Pediatrics 57(6): 722-726, June 2018.

Nelson CE, Chen A, McAndrew L, Tay KY, Balamuth F.: Management of Skin and Soft-Tissue Infections Before and After Clinical Pathway Implementation. Clinical Pediatrics 57(6): 660-666, June 2018.

Signoff JK, Fitzgerald JC, Teachey DT, Balamuth F, Weiss SL. Hypofibrinogenemia is associated with poor outcome and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome in pediatric severe sepsis. Pediatric Critical Care Medicine 2018;19(5):397-405.

Idris I, Alpern E, Angus D, Friedrich M, Kissoon N, Lemeshow S, Levy M, Parker M, Terry K, Watson S, Weiss SL, Zimmerman J, Seymour C. One-hour bundle and mortality during mandated care for pediatric sepsis. JAMA 2018;320(4):358-367.

Fitzgerald JC, Ross ME, Thomas NJ, Weiss SL, Balamuth F, Hyre Anderson A. Risk factors and inpatient outcomes associated with acute kidney injury at pediatric severe sepsis presentation. Pediatric Nephrology 2018;33(10):1781-1790.

Irving SY, Daly B, Verger J, Typpo KV, Brown A, Hanlon A, Weiss SL, Fitzgerald JC, Nadkarni VM, Thomas NJ, Srinivasan V for the SPROUT Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The association of nutrition status and nutrition support with outcomes in children with severe sepsis: a secondary analysis from the Sepsis, Prevalence, Outcomes, and Therapies (SPROUT) study. Critical Care Medicine 2018;46(11):e1029-e1039.

Lindell, RB, Nishisaki A, Weiss SL, Balamuth F, Traynor DM, Chilutti MR, Grundmeier RW, Fitzgerald JF. Comparison of methods for identification of pediatric severe sepsis and septic shock in the Virtual Pediatric Systems database. Critical Care Medicine 2018;47(2):e129-e135.

Stenson EK, Cvijanovich NZ, Allen GL, MD, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Jain PN, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak N, Lutfi R, Gertz S, Grunwell JR, Wong HR, Anas N.  Hyperchloremia is associated with acute kidney injury in pediatric patients with septic shock. Intensive Care Medicine 2018;44(11):2004-2005.

Rowan CM, Loomis A, McArthur J, Smith LS, Gertz SJ, Fitzgerald JC, Nitu ME, Moser EA, Hsing DD, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Tamburro RF, Cheifetz IM: High-frequency oscillatory ventilation use and severe pediatric ARDS in the pediatric hematopoietic cell transplant recipient. Respiratory Care 63(4): 404-411, April 2018.

Yehya N, Thomas NJ, Khemani RG: Risk stratification using oxygenation in the first 24 hours of pediatric acute respiratory distress syndrome. Critical Care Medicine 46(4):619-624, Apr 2018.

Downes, KJ, Fitzgerald JC, Schriver E, Boge C, Russo M, Weiss SL, Balamuth F, Kubis SE, Tolomeo P, Bilker W, Han JH, Lautenbach E, Coffin SE, Gerber JS, for the CDC Prevention Epicenters Program. Implementation of a pragmatic biomarker-driven algorithm to guide antibiotic use in the pediatric intensive care unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) II study. Journal of the Pediatric Infectious Diseases Society 2018 Nov 22. doi: 10.1093/jpids/piy113. [Epub ahead of print].

Fitzgerald JC, Weiss SL. Taking meaning from numbers in regional epidemiologic data [Invited editorial]. The Lancet Child & Adolescent Health 2018 In Press.

Weiss SL, Watson RS. Measuring hospital performance in pediatric sepsis:  without reliable risk there is no reward [Invited editorial]. Pediatric Critical Care Medicine 2018;19(5)489-490.

Weiss SL, Deutschman CS. Are septic children really just “septic little adults”? [Invited editorial on Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit]. Intensive Care Medicine 2018;44(3):392-394.

Weiss SL, Peters M. Focus on Paediatrics: 2017. Intensive Care Medicine 2018;44(2):235-237.

P Gala, R Scarfone, A Murray, and F Balamuth: Eliminating lumbar puncture for low-risk febrile infants: A quality improvement initiative. Pediatric Emergency Care in press 2018.

Andrea T. Cruz, MD, MPH,1 Stephen B. Freedman, MDCM, MSc,2 Dina M. Kulik, MD,3 Pamela J. Okada, MD,4 Alesia H. Fleming, MD, MPH,5 Rakesh D. Mistry, MD, MS,6 Joanna E. Thomson, MD, MPH,7 David Schnadower, MD, MPH,8 Joseph L. Arms, MD,9 Prashant Mahajan, MD, MPH, MBA,10 Aris C. Garro, MD, MPH,11 Christopher M. Pruitt, MD,12 Fran Balamuth, MD, PhD,13 Neil G. Uspal, MD,14  Paul L. Aronson, MD,15 Todd W. Lyons, MD,16 Amy D. Thompson, MD,17 Sarah J. Curtis, MD, MSc,18 Paul T. Ishimine, MD,19 Suzanne M. Schmidt, MD,20 Stuart A. Bradin, DO,21 Kendra L. Grether-Jones, MD,22 Aaron S. Miller, MD, MSPH,23 Jeffrey Louie, MD,24 Samir S. Shah, MD, MSCE,7 Lise E. Nigrovic, MD, MPH,16 and the HSV Study Group of the Pediatric Emergency Medicine Collaborative Research Committee: Herpes Simplex Virus Infection in Infants u8804 60-days-old Undergoing Evaluation for Meningitis. Pediatrics 141(2): 1688, February 2018.

Zubrow ME, Thomas NJ, Friedman DF, Yehya N: RBC transfusions are associated with prolonged mechanical ventilation in pediatric acute respiratory distress syndrome. Pediatric Critical Care Medicine 19(2):e88-e96, Feb 2018.

Srinivasan L, Kilpatrick L, Shah SS, Abbasi S, Harris MC: Elevations of novel cytokines in bacterial meningitis in infants. PLoS One 13(2), February 2018 Notes: e0181449. doi: 10.1371/journal.pone.0181449. eCollection 2018

Yehya N, Wong HR: Adaptation of a Biomarker-Based Sepsis Mortality Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine 46(1): e9-e16, Jan 2018.

2017

Srinivasan L, Page G, Kirpalani H, Murray JC, Das A, Higgins RD, Carlo WA, Bell EF, Goldberg RN, Schibler K, Sood BG, Stevenson DK, Stoll BJ, Van Meurs KP, Johnson KJ, Levy J, McDonald SA, Zaterka-Baxter KM, Kennedy KA, Sánchez PJ, Duara S, Walsh MC, Shankaran S, Wynn JL, Cotten CM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed. 2017 Sep; 102(5):F439-F445.

Lin JC, Spinella PC, Fitzgerald JC, Tucci M, Bush JL, Nadkarni VM, Thomas NJ, Weiss SL for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. New or Progressive Multiple Organ Dysfunction Syndrome (NPMODS) in Pediatric Severe Sepsis: A Sepsis Phenotype with Higher Morbidity and Mortality. Pediatr Crit Care Med. 2017 Jan;18(1):8-16.

Weiss SL, Keele L, Balamuth F, Vendetti N, Ross R, Fitzgerald JC, Gerber JS. Crystalloid Fluid Choice and Clinical Outcomes in Pediatric Sepsis: A Matched Retrospective Cohort Study. J Pediatr. 2017 Mar;182:304-310.e10.

Downes KJ, Weiss SL, Klieger SB, Fitzgerald JC, Balamuth F, Kubis S, Tolomeo P, Bilker W, Han X, Nachamkin I, Garrigan C, Han J, Lautenbach E. Gerber JS, Coffin S for The CDC Prevention Epicenters Program. A Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: The Optimizing Antibiotic Strategies in Sepsis (OASIS) Study. J Pediatric Infect Dis Soc. 2017 Jun 1;6(2):134-141.

Han M, Fitzgerald JC, Balamuth F, Keele L, Alpern ER, Lavelle J, Chilutti M, Grundmeier RW, Nadkarni VM, Thomas NJ, Weiss SL. Association of Delayed Antimicrobial Therapy with One-Year Mortality in Pediatric Sepsis. Shock. 2017 Jul;48(1):29-35.

Gordon SM, Srinivasan L, Harris MC: Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics. Frontiers in Pediatrics 5: 139, June 2017 Notes: doi: 10.3389/fped.2017.00139. eCollection 2017.

Weiss SL, Asaro LA, Flori HR, Allen GL, Wypij D, Curley MAQ. Multiple Organ Dysfunction in Children Mechanically Ventilated for Acute Respiratory Failure. Pediatr Crit Care Med. 2017 Apr;18(4):319-329.

Balamuth F, Alpern ER, Funari MK, Hayes K, Schast A, Lavelle J, Fitzgerald JC, Weiss SL, Zorc JJ. Improving Recognition of Pediatric Severe Sepsis in the Emergency Department: Contributions of a Vital Sign Based Electronic Alert and Bedside Clinician Identification. Ann Emerg Med. 2017 Jun 2. pii: S0196-0644(17)30315-3.

Weiss SL, Balamuth F, Hensley J, Fitzgerald JC, Bush J, Nadkarni VM, Thomas NJ, Hall M, Muszynski J. The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children With Sepsis Die. Pediatr Crit Care Med. 2017 May 25.

2016

Srinivasan L, Kilpatrick L, Shah SS, Abbasi S, Harris M C: Cerebrospinal Fluid Cytokines in the Diagnosis of Bacterial Meningitis in Infants. Pediatr Res. 2016 Oct; 80(4):566-72.

Klieger SB, Fitzgerald JC, Weiss SL, Balamuth F, Teszner E, Sammons JS, Coffin SE. Pediatric Severe Sepsis/Septic Shock Associated with Healthcare-Associated Infections. Infect Control Hosp Epidemiol. 2016 Apr;37(4):483-5.

Giuliano JS, Jr, Markovitz BP, Brierley J, Levin R, Williams G,  Lum LC, Dorofaeff T, Cruces P, Bush JL, Keele L, Nadkarni VM, Thomas NJ, Fitzgerald JC, Weiss SL for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs.  Pediatr Crit Care Med. 2016 Jun;17(6):522-30.

Balamuth F, Weiss SL, Fitzgerald JC, Hayes K, Centkowski S, Chilutti M, Grundmeier R, Lavelle J, Alpern ER. Protocolized Treatment Is Associated With Decreased Organ Dysfunction in Pediatric Severe Sepsis. Pediatr Crit Care Med. 2016 Sep;17(9):817-22.

Lautz AJ, Dziorny AC, Denson AR, O’Connor KA, Chilutti MR, Ross RK, Gerber JS, Weiss SL. Value of Procalcitonin Measurement for Early Evidence of Severe Bacterial Infections in the Pediatric Intensive Care Unit. J Pediatr. 2016 Dec;179:74-81.e2.

Fitzgerald JC, Basu R, Akcan-Arikan A, Izquierdo LM, Pineres Olave BE, Hassinger AB, Szczepanski M, Deep A, Williams D, Sapru A, Roy JA, Nadkarni VM, Thomas NJ, Weiss SL, Furth S for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Acute Kidney Injury in Pediatric Severe Sepsis: An Independent Risk Factor for Death and New Disability. Crit Care Med. 2016 Dec;44(12):2241-2250.

2015

Weiss SL, Selak MA, Tuluc F, Perales-Villarroel JP, Nadkarni VM, Deutschman CS, Becker, LB. Mitochondrial Dysfunction in Peripheral Mononuclear Cells in Pediatric Septic Shock. Pediatr Crit Care Med. 2015 Jan;16(1):e4-e12.

Weiss SL*, Fitzgerald JC*, PappacHan J, Wheeler D, Jaramillo-Bustamante JC, Salloo A, Singhi SC, Erickson S, Roy JA, Bush JL, Nadkarni VM, Thomas NJ for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study. Am J Respir Crit Care Med. 2015 May 15;191(10):1147-57.  (*contributed equally)

Balamuth F, Alpern ER, Weiss SL, Grundmeier R, Chilutti M, Fitzgerald JC, Hayes K, Bilker W, Lautenbach E. Comparison of Two Sepsis Recognition Methods in a Pediatric Emergency Department. Acad Emerg Med. 2015 Nov;22(11):1298-306.

Weiss SL, Fitzgerald JC, Maffei F, Kane JM, Rodriguez-Nunez A, Hsing DD, Franzon D, Ying Kee S, Bush JL, Roy JA, Thomas, NJ, Nadkarnin VM for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Discordant Identification of Pediatric Severe Sepsis by Research and Clinical Definitions in the SPROUT International Point Prevalence Study. Crit Care. 2015 Sep 16;19:325

Balamuth F, Weiss SL, Hall M, Neuman MI, Scott H, Brady PW, Paul R, Farris RWD, McClead R, Centkowski S, Baumer S, Weiser J, Hayes K, Shah SS, Alpern ER. Identifying pediatric severe sepsis and septic shock: accuracy of diagnosis codes. J Pediatr. 2015 Dec;167(6):1295-300.e4.

2014

Weiss SL, Fitzgerald JC, Faustino EV, Festa MS, Fink EL, Jouvet P, Bush JL, Kissoon N, Marshall J, Nadkarni VM, Thomas NJ. Understanding the Global Epidemiology of Pediatric Critical Illness: The Power, Pitfalls, and Practicalities of Point Prevalence Studies. Pediatr Crit Care Med. 2014 Sep;15(7):660-666.

Weiss SL, Fitzgerald JC, Balamuth F, Alpern ER, Lavelle J, Chilutti M, Grundmeier R, Nadkarni VM, Thomas NJ. Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Crit Care Med. 2014 Nov;42(11):2409-17.

Balamuth F, Weiss SL, Neuman MI, Scott H, Brady PW, Paul R, Farris RWD, McClead R, Hayes K, Gaieski D, Hall M, Shah SS, Alpern ER. Pediatric Severe Sepsis in US Children's Hospitals. Pediatr Crit Care Med. 2014 Nov;15(9):798-805.

Abstracts and presentations

2019

Balamuth F, Kittick M, McBride P, Woodford AL, Vestal N, Casper TC, Metheney M, Smith K, Atkin NK, Baren J, Dean JM, Kuppermann N, Weiss SL. Pragmatic pediatric trial of balanced versus normal saline fluid in sepsis: the PRoMPT BOLUS pilot feasibility study. Poster Presentation at the Pediatric Academic Societies’ Annual Meeting, 2019 April 27-30, Baltimore, MD.

Balamuth F, Scott H, Weiss SL, Webb M, Chamberlain J, Bajaj L, Depinet H, Grundmeier R, Deakyne-Davies S, Simon NJ, Cook L, Alpern E. Validation of the Pediatric Sequential Organ Failure Assessment Score and Evaluation of Sepsis-3 Definitions in the Pediatric Emergency Department. Platform Presentation at the Pediatric Academic Societies’ Annual Meeting, 2019 April 27-30, Baltimore, MD.

Wildenhain P, Oliver A, Kaminski S, Weiss SL, Bird G, Woods-Hill C, Biedron L. The alert that cried wolf: mitigating alert fatigue in critical care areas. Poster Presentation at the Improving Pediatric Sepsis Outcomes Workshop, 2018 December 6-7, Dallas, TX. Published in Pediatric Quality and Safety 2019.

Finnegan L, Harris M, Coggins S, Schmatz M, Tremoglie-Barkowski M, Srinivasan S. Suspected Sepsis in the NICU: Leveraging Staff Perceptions of Delays in Antibiotic Administration to Drive Improvement.  ESPR (podium presentation), SPR (poster) 2019. Platform presentation, Eastern Society Pediatric Research, Philadelphia, PA March 2019. Poster presentation, Society for Pediatric Research, Baltimore, MD May 2019.

Sivakumar N, Srinivasan L, Grundmeier R, Schmatz M, Harris MC.  Demystifying “Culture-negative sepsis”: Reasons for prolonged antibiotic administration in the NICU. Poster presentation, Eastern Society Pediatric Research, Philadelphia, PA March 2019. Poster presentation, Society for Pediatric Research, Baltimore, MD May 2019.

Coggins S, Harris MC, Grundmeier R, Nawab U, Srinivasan L. Pediatric SIRS and organ dysfunction criteria in late-onset sepsis in a quaternary NICU: a case-control study. Poster presentation, Eastern Society Pediatric Research, Philadelphia, PA March 2019. Poster presentation, Society for Pediatric Research, Baltimore, MD May 2019.

Karavite D, Muthu N, Shaeffer G, Balamuth F, Harris MC, Grundmeier, R.  Lessons Learned from Knowledge Elicitation in Complex Clinical Environments: Iteration is not just for Design. Workshop presentation, Human Factors and Ergonomic Society (HFES) Healthcare Symposium. Chicago, Illinois, March, 2019.

Kharayat P, Conway J, Sanders R, Nett S, Zeqo J, Weiss SL, Edwards L, Kirby A, Krawiec C, Page-Goertz C, Polikoff L, Turner D, Nadkarni V, Nishisaki A. Dose effect of ketamine on hemodynamic outcomes among critically ill children with and without shock. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Conway J, Kharayat P, Sanders R, Nett S, Weiss SL, Edwards L, Page-Goertz C, Zeqo J, Kirby A, Krawiec C, Polikoff L, Turner D, Nadkarni V, Nishisaki A. Ketamine use in tracheal intubation and adverse hemodynamic events. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Morgan R, Yeung T, Landis WP, Nadkarni VM, Berg RA, Weiss SL, Kilbaugh TJ, Topjian AA, Sutton RM. Post-arrest inflammatory markers and outcomes from pediatric in-hospital cardiac arrest. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Ginsburg S, Conlon T, Himebach A, Glau C, Weiss SL, O’Connor M, Nishisaki A. Prevalence of LV diastolic dysfunction and association with outcomes in septic pediatric patients. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Becker A, Fitzgerald J, Kubis S, Traynor D, Vossough A, Weiss SL, Topjian A, Kirschen M. MRI abnormalities in pediatric sepsis. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Chiotos K, Biedron L, Fitzgerald J, Robbins-Tighe S, Weiss SL, Woods-Hill C. Sepsis huddles in the PICU: Understanding the impact on timely antibiotics, perceptions, and barriers. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Matehuala S, Pasala S, Goudi A, Fiser R, Weiss SL, Irby K, Crary S, Wang A, Sanders R. Red blood cell distribution width values predict multiorgan failure in children admitted to the PICU. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Lindell R, Nishisaki A, Weiss SL, Traynor D, Fitzgerald JC. Risk of mortality in immunocompromised children with severe sepsis and septic shock. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Lindell R, Fitzgerald JC, Nishisaki A, Traynor D, Weiss SL. Predictive validity of mortality prediction scores in pediatric severe sepsis and septic shock. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Glau GL, Conlon TW, Yehya N, Weiss SL, Himebach AD, Nishisaki A. Pediatric diaphragm atrophy is associated with prolonged non-invasive support following extubation. Star Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Whitney J, Bush J, Graham K, Chen F, Kengle N, Lacey S, Melenhorst JJ, Yehya N, Weiss SL. Endothelial activation is more prominent in indirect versus direct pediatric ARDS. Star Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Walker S, Conlon T, Zhang B, Mensinger J, Fitzgerald J, Himebauch A, Glau C, Nishisaki A, Ranjit S, Nadkarni V, Weiss SL. Targeting vasoactives to warm versus cold pediatric septic shock. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

2018

Kaminski S, Morris K, Weiss SL, Wildenhain P, Abbadess MK, Digerolamo K, Fitzgerald JC, Hadley S, Keren R. Measuring the continuum of sepsis care: development of new metrics for sepsis screening. Poster Presentation at the Improving Pediatric Sepsis Outcomes Workshop, 2018 December 6-7, Dallas, TX.

Masino AJ, Harris MC, Forsyth D, Ostapenko S, Grundmeier RW. Machine Learning Models for Infant Sepsis Prediction. Podium presentation, AMIA Annual Symposium. San Francisco, CA November, 2018.

Schmatz M, Srinivasan L, Grundmeier R, Ostapenko S, Chilluti M, Harris MC: Surviving Sepsis in the NICU: Delayed Antimicrobial Therapy Worsens Outcomes in Late Onset Sepsis. Poster presentation, Society for Pediatric Research at the Pediatric Academic Society Annual Meeting, Toronto, Ontario, Canada May 2018.

Kalb E, Coggins S, Harris MC, Nawab U, Grundmeier R, Srinivasan L: Applicability of systemic inflammatory response syndrome (SIRS) and severe sepsis definitions to late onset infections in a quaternary NICU. Poster presentation, Society for Pediatric Research at the Pediatric Academic Society Annual Meeting, Toronto, Ontario, Canada May 2018.

Whitney J, Yehya N, Weiss SL. IL-6 at sepsis recognition is associated with poor functional outcome. Oral presentation, 25^th Pediatric Critical Care Colloquium, 2018 October 5-7, Baltimore, MD.

Weiss SL, Zhang D, Bush J, Star J, Kilbaugh T, Deutschman CS, Becker L, McGowan FX, Wallace D. Decreased immune cell mitochondrial respiration is not associated with organ dysfunction or early death in pediatric sepsis. Shock 2018;49(Suppl 1):131 [Poster presentation, Shock Society 2018 Annual Meeting, 2018 June 9-12, Scottsdale, AZ].

Walker S, Conlon T, Zhang B, Mensinger J, Fitzgerald J, Himebauch A, Glau C, Nishisaki A, Ranjit S, Nadkarni V, Weiss SL. Application of Clinical Signs to Differentiate Warm versus Cold Pediatric Septic Shock. Poster presentation, Pediatric Academic Societies’ Annual Meeting, 2018 May 5-8, Toronto, Canada.

Schmatz M, Srinivasan L, Grundmeier R, Ostapenko S, Chilluti M, Harris MC: Surviving Sepsis in the NICU: Delayed Antimicrobial Therapy Worsens Outcomes in Late Onset Sepsis. Poster presentation, Eastern Society for Pediatric Research, Philadelphia, PA March 2018.

Kalb E, Coggins S, Harris MC, Nawab U, Grundmeier R, Srinivasan L: Applicability of systemic inflammatory response syndrome (SIRS) and severe sepsis definitions to late onset infections in a quaternary NICU. Poster presentation, Eastern Society for Pediatric Research, Philadelphia, PA March 2018.

Coggins S, Kalb, E, Harris MC, Nawab U, Grudmeier R, Srinivasan L: Factors Associated with Delayed Recognition of Sepsis in a Quaternary NICU. Poster presentation, Eastern Society for Pediatric Research, Philadelphia, PA March 2018.

Whitney J, Yehya N, Weiss SL. Increased endothelial activation is evident if pediatric extrapulmonary sepsis complicated by ARDS. Research Presentation at the 47th Society of Critical Care Medicine Annual Congress, 2018 February 25-28, San Antonio, Texas.

Han M, Roberts A, Allen B, Cardenas AM, Weiss SL. Cytomegalovirus reactivation viremia in pediatric sepsis. Research Presentation at the 47th Society of Critical Care Medicine Annual Congress, 2018 February 25-28, San Antonio, Texas.

Dziorny A, Fitzgerald J, Weiss SL. A data-driven quality improvement initiative to reduce unnecessary laboratory testing in the PICU. Research Presentation at the 47th Society of Critical Care Medicine Annual Congress, 2018 February 25-28, San Antonio, Texas.

2018

Kalb E, Coggins S, Harris MC, Ursula Nawab, Grundmeier R, Srinivasan L. "Applicability of systemic inflammatory response syndrome (SIRS) and severe sepsis definitions to late onset infections in a quaternary NICU." (Poster presentations at Society for Pediatric Research, Toronto, Canada 2018 and Eastern Society for Pediatric Research, Philadelphia 2018).

Schmatz M, Srinivasan L, Grundmeier R, Ostapenko S, Chilutti M, Harris MC. "Surviving Sepsis in the NICU: Delayed Antimicrobial Therapy Worsens Outcomes." (Poster presentations at Society for Pediatric Research, Toronto, Canada 2018 and Eastern Society for Pediatric Research, Philadelphia 2018).

Coggins S, Kalb E, Harris MC, Nawab U, Grundmeier R, Srinivasan L. "Factors associated with delayed recognition of sepsis in a quarternary NICU." (Poster presentation at Eastern Society for Pediatric Research, Philadelphia 2018).

2017

Skraban C, Herrick H, Medne L, Harris MC, Santani A, Zackai E: Acinar Dysplasia, Tbx4 and Lung Branching Morphogenesis. Platform presentation by collaborator, poster presentation, 38th Annual David W. Smith Workshop on Malformations and Morphogenesis, Stowe, VT August 2017.

Weiss SL, Zhang D, Graham K, Deutschman CS, Kilbaugh T, McGowan F, Becker L,  Wallace D. Reduced Mitochondrial Mass Underlays Decreased Respiration in Septic Immune Cells. Star Research Presentation at the 46th Critical Care Congress, January 22-25, 2017, Honolulu, Hawaii.

Weiss SL, Balamuth F, Fitzgerald J, Hensley J, Bush J, Thomas N, Hall M, Muszynski J. Epidemiology of Death Following Pediatric Sepsis: When, Why, and How Septic Kids Die. Research Snapshot Presentation at the 46th Critical Care Congress, January 22-25, 2017, Honolulu, Hawaii.

Gu H, Keele L, Hayes K, Fitzgerald J, Weiss SL, Balamuth F. Machine Learning Predictive Modeling for Organ Dysfunction In Children with Suspected Sepsis in the Emergency Department. Oral presentation at the American Academy of Pediatrics Annual Meeting, September 2017, Chicago, Illinois.

Downes KJ, Schriver E, Russo M, Weiss SL, Fitzgerald JC, Balamuth F, Tolomeo P, Bilker WB, Han JH, Lautenbach E, Coffin SE, Gerber JS for the CDC Prevention Epicenters Program. Implementation of a Pragmatic Biomarker-driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: The Optimizing Antibiotic Strategies in Sepsis (OASIS) II Study. Poster presentation at the IDWeek 2017 Conference, Oct 4-8, 2017, San Diego, CA.

2016

Signoff J, Fitzgerald F, Teachey D, Balamuth F, Weiss SL. Hypofibrinogenemia Is Associated with Poor Outcome and Secondary HLH in Pediatric Severe Sepsis. Critical Care Medicine. 2015;43(12) Suppl:A260 [Research Snapshot Presentation at the 45th Critical Care Congress, February 21-24, 2016, Orlando, Florida].

Han M, Fitzgerald J, Balamuth F, Chilutti M, Grundmeier R, Nadkarni V, Thomas N, Weiss SL. Hourly Delays to Antimicrobial Therapy Do Not Increase One-year Mortality in Pediatric Severe Sepsis. Critical Care Medicine. 2015;43(12) Suppl:A272-273. [Research Snapshot Presentation at the 45th Critical Care Congress, February 21-24, 2016, Orlando, Florida].

Abaya R, Weiss SL, Fitzgerald JC, Balamuth F. Utility of Procalcitonin to Predict Intensive Care Unit Admission and Identify Bacterial Illness in the ED Resuscitation of Pediatric Sepsis. Poster presentation, Pediatric Academic Societies’ Annual Meeting, April 30-May 3, 2016, Baltimore, Maryland.

Ballantine A, DiTaranto S, Roberts K, Balamuth F, Weiss SL, Fitzgerald J, Hadley S, Minich C, Rigby V, Keren R. Improving Response to Suspected Sepsis: Results of a Hospital-wide Quality Improvement Initiative. Poster presentation, American Academy of Pediatrics National Conference & Exhibition, October 22-25, 2016, San Francisco, CA.

2015

Balamuth F, Caplan I, Scott H, Weiss SL, Fitzgerald J, Kubis S, Chilutti M, Grundmeier R, Alpern ER. Increased Risk of One-year All-cause Mortality after Pediatric Severe Sepsis. Critical Care Medicine. 2014;42(12) Suppl:A1606 [Poster Presentation at the 44th Critical Care Congress, January 2015, Phoenix, Arizona].

Klieger SB, Fitzgerald JC, Weiss SL, Balamuth F, Teszner E, Sammons JS & Coffin SE. Pediatric Severe Sepsis/Septic Shock Attributable to Healthcare-associated Infections. The Society for Healthcare Epidemiology of America (SHEA) annual meeting. May 2015, Orlando, Florida.

Dziorny A, Lautz A, Densen A, O’Connor K, Weiss SL. Procalcitonin for Early Recognition of Severe Bacterial Infections in the Pediatric Intensive Care Unit. Platform presentation, Pediatric Academic Societies’ Annual Meeting, April 25-28, 2015, San Diego, California.

Balamuth F, Funari MK, Hayes K, Schast A, Lavelle J, Fitzgerald JC, Weiss SL, Alpern ER, Zorc, JJ. Improved Emergency Department Recognition of Pediatric Severe Sepsis/Septic Shock with an Electronic Alert. Platform presentation, Pediatric Academic Societies’ Annual Meeting, April 25-28, 2015, San Diego, California.

Balamuth F, Hayes K, Centkowski S, Gagel A, Fitzgerald JC, Weiss SL, Chilutti M, Grundmeier R, Lavelle J, Alpern ER. Decreased Organ Failure in Pediatric Sepsis Treated According to a Bundled Treatment Guideline. Poster presentation, Pediatric Academic Societies’ Annual Meeting, April 25-28, 2015, San Diego, California.

Downes KJ, Weiss SL, Klieger SB, Fitzgerald JC, Balamuth F, Kubis S, Tolomeo P, Bilker W, Han X, Nachamkin I, Garrigan C, Han J, Lautenbach E. Gerber JS, Coffin S for The CDC Prevention Epicenters Program. Developing a Biomarker-driven Algorithm to Improve Antibiotic Use in the Pediatric Intensive Care Unit: The Optimizing Antibiotic Strategies in Sepsis (OASIS) Study. Oral presentation, IDWeek, October 9, 2015, San Diego, CA.

2014

Balamuth F, Weiss SL, Fitzgerald JC, Hayes K, Chilutti M, Grundmeier R, Myers S, Lautenbach E, Alpern ER. Comparison of Two Sepsis Recognition Methods in a Pediatric Emergency Department. Platform Presentation at the Pediatric Academic Societies Annual Meeting, May 2014, Vancouver, BC, Canada.

2013

Weiss SL, Fitzgerald J, Blamuth F, Alpern ER, Lavelle J, Chilutti M, Grundmeier R, Thomas N, Nadkarni VM. Surviving Sepsis in the Hospital: Location, Location, Location! Crit Care Med. 2012;40(12) Suppl:A480. [Poster presented at 42nd Critical Care Congress, Jan 19-23, 2013, San Juan, PR]

Balamuth F, Woodford A, Weiss SL, Fitzgerald J, Chilutti M, Grundmeier R, Wein JN. Fesnak S, Lavelle J, Alpern ER. There’s an App for That: An Electronic Health Record Sepsis Registry and Clinical Protocol to Improve Quality of Care. Platform presentation. Pediatric Academic Societies’ Annual Meeting, May 2013, Washington, DC.

Grundmeier RW, Chilutti MR, Ostapenko S, Woodford AL, Wein JN, Czaplicki DJ, Schilling DM, Fitzgerald JC, Weiss SL, Balamuth FB, Alpern ER, Lavelle JM. Defining the Gold Standard: Manual Abstraction versus Automated Data Extraction for a Complex Sepsis Registry. Platform Presentation: 6th Annual Mid-Atlantic Healthcare Informatics Symposium, April 26, 2013, Philadelphia, PA.

Woodford AL, Weiss SL, Fitzgerald JC, Chilutti M, Grundmeier R, Lavelle J, Alpern ER, Balamuth F. Expedited Care and Reduced Length of Stay in Critically Ill Pediatric Patients with Sepsis Treated Using a Clinical Pathway and Electronic Order Set in the Emergency Department. Platform Presentation at American Academy of Pediatrics National Conference, October 2013, Orlando, FL.

Balamuth F, Weiss SL, Scott H, Paul R, Neuman M, Ferris R, McClead R, Hall M, Shah S, Alpern ER. For the PHIS Sepsis Research Working Group. Choice of Coding Strategies Directly Impact Estimates of the Epidemiology and Outcomes of Pediatric Severe Sepsis. Poster Presentation at American Academy of Pediatrics National Conference, October 2013, Orlando, FL.

Weiss SL, Villarroel JP, Selak MA, Tuluc F, Deutschman CS, Nadkarni VM, Becker LB. Mitochondrial Dysfunction in Circulating Immune Cells in Pediatric Septic Shock. Crit Care Med. 2013;41(12) Suppl:A17 [Oral Presentation at the 43rd Critical Care Congress, San Francisco, CA].

Fitzgerald JC, Weiss SL, Nadkarni VM, Bush J, Thomas NJ, for the SPROUT and PALISI Network Investigators. Global Epidemiology and Outcomes of Pediatric Severe Sepsis – The Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study. Crit Care Med. 2013;41(12) Suppl: A137 [Poster Presentation at the 43rd Critical Care Congress, San Francisco, CA].