View highlights of recent publications from the Gastrointestinal Epithelium Modeling Program at Children's Hospital of Philadelphia.

2022

Park, S.E., Kang, S., Paek, J. et al. Geometric engineering of organoid culture for enhanced organogenesis in a dish. Nat Methods 19, 1449–1460 (2022).

Dmitrieva-Posocco, O., Wong, A.C., Lundgren, P. et al. β-Hydroxybutyrate suppresses colorectal cancer. Nature 605, 160–165 (2022). 

Kabir, M.F., Karami, A.L., Cruz-Acuña, R. et al. Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium. Nat Commun 13, 2167 (2022).

Takeo Hara, MD, PhD, Yuta Kasagi, MD, PhD, Joshua Wang, Masaru Sasaki, Bailey Aaron, Adam Karami, Masataka Shimonosono, MD, PhD, Rieko Shimonosono, MD, Hisatsugu Maekawa, MD, PhD, Lauren Dolinsky, Benjamin Wilkins, MD, PhD, Jeremy Klein, Jane Wei, Kathryn Nunes, Kristle Lynch, MD, Jonathan M. Spergel, MD, PhD, Kathryn E. Hamilton, PhD, Melanie A. Ruffner, MD, PhD, Tatiana A. Karakasheva, PhD, Kelly A. Whelan, PhD, Hiroshi Nakagawa, MD, PhD, Amanda B. Muir, MD. CD73+ epithelial progenitor cells which contribute to homeostasis and renewal are depleted in eosinophilic esophagitis. Cell Mol Gastroenterol Hepatol. 2022 Jan 30;S2352-345X(22)00018-2. doi: 10.1016/j.jcmgh.2022.01.018. Online ahead of print.

2021

Tang Q, Lento A, Suzuki K, Efe G, Karakasheva T, Long A, Giroux V, Islam M, Wileyto EP, Klein-Szanto AJ, Nakagawa H, Bass A, Rustig AK. Rab11‐FIP1 mediates epithelial‐mesenchymal transition and invasion in esophageal cancer. Published January 6, 2021 in EMBO reports (2021) 22:e48351.

Amanda Muir, MD, MSTR; Gary W. Falk, MD, MS. Eosinophilic Esophagitis: A Review.  JAMA. 2021;326(13):1310-1318. doi:10.1001/jama.2021.14920.

Tatiana A. Karakasheva, Joel T. Gabre, Uma M. Sachdeva, Ricardo Cruz-Acuña, Eric W. Lin, Maureen DeMarshall, Gary W. Falk, Gregory G. Ginsberg, Zhaohai Yang, Michele M. Kim, Eric S. Diffenderfer, Jason R. Pitarresi, Jinyang Li, Amanda B. Muir, Kathryn E. Hamilton, Hiroshi Nakagawa, Adam J. Bass & Anil K. Rustgi. Patient-derived organoids as a platform for modeling a patient’s response to chemoradiotherapy in esophageal cancer.  Scientific Reports volume 11, Article number: 21304 (2021).

2020

Kelsen JR, Dawany N, Conrad MA … Sullivan KE, Hamilton KE. Colonoids From Patients With Pediatric Inflammatory Bowel Disease Exhibit Decreased Growth Associated With Inflammation Severity and Durable Upregulation of Antigen Presentation Genes. Published June 16, 2020 in Inflammatory Bowel Diseases, izaa145.

Karakasheva T, Kijima T, Shimonosomo M, et. al. Generation and Characterization of Patient‐Derived Head and Neck, Oral, and Esophageal Cancer Organoids. Published April 15, 2020 on Current Protocols.

Nakagawa H, Kasagi Y, Karakasheva TA Hamilton K, Muir A. Modeling Epithelial Homeostasis and Reactive Epithelial Changes in Human and Murine Three‐Dimensional Esophageal Organoids. Published Feb. 17. 2020, on Current Protocols.

2019

Chatterji P, Williams PA, Whelan KA …Hamilton K. Posttranscriptional Regulation of Colonic Epithelial Repair by RNA Binding Protein. IMP1/IGF2BP1. EMBO reports (2019) 20:e47074.

2018

Kasagi Y, Chandramouleeswaran P, Whelan KA, … Muir A. The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes. CMGH, 5(3), p. 333-352, Jan. 2, 2018.