In this study, we are developing new ultrasound and magnetic resonance imaging (MRI) methods to measure kidney and liver disease severity in autosomal recessive polycystic kidney disease (ARPKD). Participants in this study will include individuals with ARPKD, and a comparison group of healthy individuals without liver or kidney disease. Individuals of any age may take part in the study.

Urinary stone disease (USD) is a common, chronic disorder that is seen more frequently in adolescence today than in the past. Current understanding of its impact on bone development and structure as well as dental health is not known. We will be evaluating bone and dental quality in 90 children/adolescents with USD and 90 healthy children/adolescents. The study requires: two to three visits for a total of three to four hours, that the participant be 5-21 years old, and compensation will be provided. If interested in participating contact the research coordinator at 267-226-6995.