View highlights of publications from the Division of Infectious Diseases at CHOP. For more examples, please take a look at our team’s bios and lab websites.

Epidemiologic/clinical researchers and Pediatric IDEAs group

1. Downes KJ, Cowden C, Laskin BL, Huang YS, Gong W, Bryan M, Fisher BT, Goldstein SL, Zaoutis TE. Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children. JAMA Pediatr. 2017 Dec 4;171(12):e173219. PMID: 28973124. doi: 10.1001/jamapediatrics.2017.3219.
2. Gerber JS, Ross RK, Bryan M, Localio AR, Szymczak JE, Wasserman R, Barkman D, Odeniyi F, Conaboy K, Bell L, Zaoutis TE, Fiks AG. Association of Broad- vs Narrow-Spectrum Antibiotics With Treatment Failure, Adverse Events, and Quality of Life in Children With Acute Respiratory Tract Infections. JAMA. 2017 Dec 19;318(23):2325-2336. PMID: 29260224. doi: 10.1001/jama.2017.18715.
3. Tribble AC, Ross RK, Gerber JS. Comparison of Antibiotic Prescribing for Pediatric Community-Acquired Pneumonia in Children's and Non-Children's Hospitals. JAMA Pediatr. 2019 Feb 1;173(2):190-192. PMID: 30534969. doi: 10.1001/jamapediatrics.2018.4270.
4. Feemster K, Localio R, Grundmeier R, Metlay JP, Coffin SE. Incidence of Healthcare-Associated Influenza-Like Illness After a Primary Care Encounter Among Young Children. J Pediatric Infect Dis Soc. 2019 Jul 1;8(3):191-196. PMID: 29579251. doi: 10.1093/jpids/piy023.
5. Fisher BT, Zaoutis T, Dvorak CC, Nieder M, Zerr D, Wingard JR, Callahan C, Villaluna D, Chen L, Dang H, Esbenshade AJ, Alexander S, Wiley JM, Sung L. Effect of Caspofungin vs Fluconazole Prophylaxis on Invasive Fungal Disease Among Children and Young Adults With Acute Myeloid Leukemia: A Randomized Clinical Trial. JAMA. 2019 Nov 5;322(17):1673-1681. PMID: 31688884. doi: 10.1001/jama.2019.15702.
6. Downes KJ, Fitzgerald JC, Schriver E, Boge CLK, Russo ME, Weiss SL, Balamuth F, Kubis SE, Tolomeo P, Bilker WB, Han JH, Lautenbach E, Coffin SE, Gerber JS. Implementation of a Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) II Study. J Pediatric Infect Dis Soc. 2020 Feb 28;9(1):36-43. PMID: 30476186. doi: 10.1093/jpids/piy113.
7. Kitt E, Drew RJ, Cunney R, Beekmann SE, Polgreen P, Butler K, Zaoutis T, Coffin SE. Diagnosis and Management of Pediatric Influenza in the Era of Rapid Diagnostics. J Pediatric Infect Dis Soc. 2020 Feb 28;9(1):51-55. PMID: 30476135 doi: 10.1093/jpids/piy118.
8. Downes KJ, Boge CLK, Baro E, Wharton GT, Liston KM, Haltzman BL, Emerson HM, Doe E, Fulchiero R, Tran V, Yen L, Lieu P, Van Driest SL, Grisso AG, Aka IT, Hale J, Gillon J, Pingel JS, Coffin SE, McMahon AW. Acute Kidney Injury During Treatment with Intravenous Acyclovir for Suspected or Confirmed Neonatal Herpes Simplex Virus Infection. J Pediatr. 2020 Apr;219:126-132.e2. PMID: 32037154. doi: 10.1016/j.jpeds.2019.12.056.
9. Gerber JS, Jackson MA, Tamma PD, Zaoutis TE; COMMITTEE ON INFECTIOUS DISEASES, PEDIATRIC INFECTIOUS DISEASES SOCIETY. Antibiotic Stewardship in Pediatrics. Pediatrics. 2021 Jan;147(1):e2020040295. PMID: 33372120. doi: 10.1542/peds.2020-040295.
10. Elgarten CW, Li Y, Getz KD, Hemmer M, Huang YV, Hall M, Wang T, Kitko CL, Jagasia MH, Nishihori T, Murthy HS, Hashem H, Cairo MS, Sharma A, Hashmi SK, Askar M, Beitinjaneh A, Kelly MS, Auletta JJ, Badawy SM, Mavers M, Aplenc R, MacMillan ML, Spellman SR, Arora M, Fisher BT. Broad-Spectrum Antibiotics and Risk of Graft-versus-Host Disease in Pediatric Patients Undergoing Transplantation for Acute Leukemia: Association of Carbapenem Use with the Risk of Acute Graft-versus-Host Disease. Transplant Cell Ther. 2021 Feb;27(2):177.e1-177.e8. PMID: 33718896. doi: 10.1016/j.jtct.2020.10.012.
11. Dramowski A, Aucamp M, Bekker A, Pillay S, Moloto K, Whitelaw AC, Cotton MF, Coffin S. NeoCLEAN: a multimodal strategy to enhance environmental cleaning in a resource-limited neonatal unit. Antimicrob Resist Infect Control. 2021 Feb 12;10(1):35. PMID: 33579364. doi: 10.1186/s13756-021-00905-y.
12. Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, Yarbrough A, Abzug MJ, MacBrayne CE, Soma VL, Dulek DE, Vora SB, Waghmare A, Wolf J, Olivero R, Grapentine S, Wattier RL, Bio L, Cross SJ, Dillman NO, Downes KJ, Oliveira CR, Timberlake K, Young J, Orscheln RC, Tamma PD, Schwenk HT, Zachariah P, Aldrich ML, Goldman DL, Groves HE, Rajapakse NS, Lamb GS, Tribble AC, Hersh AL, Thorell EA, Denison MR, Ratner AJ, Newland JG, Nakamura MM. Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2. J Pediatric Infect Dis Soc. 2021 Feb 13;10(1):34-48. PMID: 32918548. doi: 10.1093/jpids/piaa115.
13. Coffin SE, Abanyie F, Bryant K, Cantey J, Fiore A, Fritz S, Guzman-Cottrill J, Hersh AL, Huskins WC, Kociolek LK, Kronman M, Lautenbach E, Lee G, Linam M, Logan LK, Milstone A, Newland J, Nyquist AC, Palazzi DL, Patel S, Puopolo K, Reddy SC, Saiman L, Sandora T, Shane AL, Smith M, Tamma PD, Zaoutis T, Zerr D, Gerber JS; CDC Prevention Epicenters Program. Pediatric research priorities in healthcare-associated infections and antimicrobial stewardship. Infect Control Hosp Epidemiol. 2021 May;42(5):519-522. PMID: 33239122 doi: 10.1017/ice.2020.1267.
14. Ross RK, Kinlaw AC, Herzog MM, Jonsson Funk M, Gerber JS. Fluoroquinolone Antibiotics and Tendon Injury in Adolescents. Pediatrics. 2021 Jun;147(6):e2020033316. PMID: 33990459. doi: 10.1542/peds.2020-033316.
15. Fisher BT, Zaoutis TE, Xiao R, Wattier RL, Castagnola E, Pana ZD, Fullenkamp A, Boge CLK, Ross RK, Yildirim I, Palazzi DL, Danziger-Isakov L, Vora SB, Arrieta A, Yin DE, Avilés-Robles M, Sharma T, Tribble AC, Maron G, Berman D, Green M, Sung L, Romero J, Hauger SB, Roilides E, Belani K, Nolt D, Soler-Palacin P, López-Medina E, Muller WJ, Halasa N, Dulek D, Hussain IZB, Pong A, Hoffman J, Rajan S, Gonzalez BE, Hanisch B, Aftandilian C, Carlesse F, Abzug MJ, Huppler AR, Salvatore CM, Ardura MI, Chakrabarti A, Santolaya ME, Localio AR, Steinbach WJ. Comparative Effectiveness of Echinocandins vs Triazoles or Amphotericin B Formulations as Initial Directed Therapy for Invasive Candidiasis in Children and Adolescents. J Pediatric Infect Dis Soc. 2021 Aug 10:piab024. Online ahead of print. PMID: 34374424. doi: 10.1093/jpids/piab024.
16. Laycock KM, Enane LA, Steenhoff AP. Tuberculosis in Adolescents and Young Adults: Emerging Data on TB Transmission and Prevention among Vulnerable Young People. Trop Med Infect Dis. 2021 Aug 5;6(3):148. doi: 10.3390/tropicalmed6030148. PMID: 34449722; PMCID: PMC8396328.
17. St Clair NE, Abdul-Mumin A, Banker SL, Condurache T, Crouse H, Haq H, Helphinstine J, Kazembe PN, Marton S, McQuilkin P, Pitt MB, Rus M, Russ CM, Schubert C, Schutze GE, Steenhoff AP, Uwemedimo O, Watts J, Butteris SM; GLOBAL HEALTH TASK FORCE OF THE AMERICAN BOARD OF PEDIATRICS. Global Guide: A Comprehensive Global Health Education Resource for Pediatric Program Directors. Pediatrics. 2020 Feb;145(2):e20192138. doi: 10.1542/peds.2019-2138. Epub 2020 Jan 3. PMID: 31900316.

Basic/translational research

1. Moustafa AM, Planet PJ. Emerging SARS-CoV-2 diversity revealed by rapid whole genome sequence typing. Genome Biol Evol. 2021 Aug 25:evab197. doi: 10.1093/gbe/evab197. Epub ahead of print. PMID: 34432021.
2. Moustafa AM, Velusamy SK, Denu L, Narechania A, Fine DH, Planet PJ. Adaptation by Ancient Horizontal Acquisition of Butyrate Metabolism Genes in Aggregatibacter actinomycetemcomitans. mBio. 2021 Mar 23;12(2):e03581-20. doi: 10.1128/mBio.03581-20. PMID: 33758084; PMCID: PMC8092312.
3. Kadry NA, Porsch EA, Shen H, St Geme JW 3rd. Immunization with HMW1 and HMW2 adhesins protects against colonization by heterologous strains of nontypeable Haemophilus influenzae. Proc Natl Acad Sci U S A. 2021 Aug 10;118(32):e2019923118. doi: 10.1073/pnas.2019923118. PMID: 34344825; PMCID: PMC8364133.
4. Muñoz VL, Porsch EA, St Geme JW 3rd. Kingella kingae Surface Polysaccharides Promote Resistance to Neutrophil Phagocytosis and Killing. mBio. 2019 Jun 25;10(3):e00631-19. doi: 10.1128/mBio.00631-19. PMID: 31239373; PMCID: PMC6593399.
5. Miller JJ, Shah IT, Hatten J, Barekatain Y, Mueller EA, Moustafa AM, Edwards RL, Dowd CS, Planet PJ, Muller FL, Jez JM, Odom John AR. Structure-guided microbial targeting of antistaphylococcal prodrugs. eLife. 2021 Jul 19;10:e66657. doi: 10.7554/eLife.66657. PMID: 34279224; PMCID: PMC8318587.
6. Mathews ES, Jezewski AJ, Odom John AR. Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites. mBio. 2021 Jun 29;12(3):e0076021. doi: 10.1128/mBio.00760-21. Epub 2021 Jun 29. PMID: 34182772; PMCID: PMC8262983.
7. Lin EE, Akaho EH, Sobilo A, Young LR, Harris RM, Odom John AR. Concordance of Preprocedure Testing With Time-of-Surgery Testing for SARS-CoV-2 in Children. Pediatrics. 2021 Apr;147(4):e2020044289. doi: 10.1542/peds.2020-044289. Epub 2021 Feb 2. PMID: 33531335; PMCID: PMC8015151.
8. Berna AZ, Akaho EH, Harris RM, Congdon M, Korn E, Neher S, M'Farrej M, Burns J, Odom John AR. Reproducible Breath Metabolite Changes in Children with SARS-CoV-2 Infection. ACS Infect Dis. 2021 Sep 10;7(9):2596-2603. doi: 10.1021/acsinfecdis.1c00248. Epub 2021 Jul 28. PMID: 34319698; PMCID: PMC8353987.
9. Dulek DE, Fuhlbrigge RC, Tribble AC, Connelly JA, Loi MM, El Chebib H, Chandrakasan S, Otto WR, Diorio C, Keim G, Walkovich K, Jaggi P, Girotto JE, Yarbrough A, Behrens EM, Cron RQ, Bassiri H. Multidisciplinary Guidance Regarding the Use of Immunomodulatory Therapies for Acute Coronavirus Disease 2019 in Pediatric Patients. J Pediatric Infect Dis Soc. 2020 Dec 31;9(6):716-737. doi: 10.1093/jpids/piaa098. PMID: 32808988; PMCID: PMC7454742.
10. Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase J, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell BL, Bernt KM, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, John ARO, Lambert M, Liebling EJ, Paessler ME, Petrosa W, Phillips C, Reilly AF, Romberg ND, Seif A, Sesok-Pizzini DA, Sullivan KE, Vardaro J, Behrens EM, Teachey DT, Bassiri H. Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2. J Clin Invest. 2020 Nov 2;130(11):5967-5975. doi: 10.1172/JCI140970. PMID: 32730233; PMCID: PMC7598044.
11. Khurana P, Burudpakdee C, Grupp SA, Beier UH, Barrett DM, Bassiri H. Distinct Bioenergetic Features of Human Invariant Natural Killer T Cells Enable Retained Functions in Nutrient-Deprived States. Front Immunol. 2021 Aug 9;12:700374. doi: 10.3389/fimmu.2021.700374. PMID: 34434191; PMCID: PMC8380770.
12. Vella LA, Giles JR, Baxter AE, Oldridge DA, Diorio C, Kuri-Cervantes L, Alanio C, Pampena MB, Wu JE, Chen Z, Huang YJ, Anderson EM, Gouma S, McNerney KO, Chase J, Burudpakdee C, Lee JH, Apostolidis SA, Huang AC, Mathew D, Kuthuru O, Goodwin EC, Weirick ME, Bolton MJ, Arevalo CP, Ramos A, Jasen CJ, Conrey PE, Sayed S, Giannini HM, D'Andrea K; UPenn COVID Processing Unit, Meyer NJ, Behrens EM, Bassiri H, Hensley SE, Henrickson SE, Teachey DT, Betts MR, Wherry EJ. Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19. Sci Immunol. 2021 Mar 2;6(57):eabf7570. doi: 10.1126/sciimmunol.abf7570. PMID: 33653907; PMCID: PMC8128303.
13. Vella LA, Buggert M, Manne S, Herati RS, Sayin I, Kuri-Cervantes L, Bukh Brody I, O'Boyle KC, Kaprielian H, Giles JR, Nguyen S, Muselman A, Antel JP, Bar-Or A, Johnson ME, Canaday DH, Naji A, Ganusov VV, Laufer TM, Wells AD, Dori Y, Itkin MG, Betts MR, Wherry EJ. T follicular helper cells in human efferent lymph retain lymphoid characteristics. J Clin Invest. 2019 Jul 2;129(8):3185-3200. doi: 10.1172/JCI125628. PMID: 31264971; PMCID: PMC6668682.
14. Denu L, Lubin JB, Douglas B, Tuluc F, Silverman MA. Diet-induced microbial autofluorescence confounds flow cytometry of ex vivo isolated fecal microbes. Eur J Immunol. 2019 Dec;49(12):2252-2254. doi: 10.1002/eji.201948087. Epub 2019 Sep 13. PMID: 31429932.