Congenital diaphragmatic hernia (CDH) publications

Congenital diaphragmatic hernia (CDH) publications

A World Leader in CDH Research

The following list of publications will help you in your search for more information about congenital diaphragmatic hernia (CDH). Most are written by members of the Fetal Diagnosis and Treatment team at The Children's Hospital of Philadelphia. If you are unable to obtain any of these publications about congenital diaphragmatic hernia, please let us know, and we will send copies to you. 

Journal articles

2020

Therapy at 30 days of life predicts lung function at 6 to 12 months in infants with congenital diaphragmatic hernia. Chotzoglou E, Hedrick HL, Herkert LM, Goldshore MA, Rintoul NE, Panitch HB. Pediatr Pulmonol. 2020 Mar 19. doi: 10.1002/ppul.24736. [Epub ahead of print] PMID: 32191392 [PubMed - as supplied by publisher]

Inhaled Nitric Oxide Is Associated with Improved Oxygenation in a Subpopulation of Infants with Congenital Diaphragmatic Hernia and Pulmonary Hypertension. Lawrence KM, Monos S, Adams S, Herkert L, Peranteau WH, Munson DA, Hopper RK, Avitabile CM, Rintoul NE, Hedrick HL. J Pediatr. 2020 Apr;219:167-172. doi: 10.1016/j.jpeds.2019.09.052. Epub 2019 Nov 6. PMID: 31706636 [PubMed - in process]

2019

Initiating resuscitation before umbilical cord clamping in infants with congenital diaphragmatic hernia: a pilot feasibility trial. Foglia EE, Ades A, Hedrick HL, Rintoul N, Munson DA, Moldenhauer J, Gebb J, Serletti B, Chaudhary A, Weinberg DD, Napolitano N, Fraga MV, Ratcliffe SJ. Arch Dis Child Fetal Neonatal Ed. 2019 Aug 28. pii: fetalneonatal-2019-317477. doi: 10.1136/archdischild-2019-317477. [Epub ahead of print] PMID: 31462406

Sedation Practices of Neonates Receiving Extracorporeal Membrane Oxygenation. Franciscovich CD, Monk HM, Brodecki D, Rogers R, Rintoul NE, Hedrick HL, Ely E. ASAIO J. 2019 Aug 6. doi: 10.1097/MAT.0000000000001043. [Epub ahead of print] PMID: 31425254

Spatz DL, Froh EB, Bartholomew D, Edwards T, Wild KT, Hedrick H, Nawab U. Lactation Experience of Mothers and Feeding Outcomes of Infants with Congenital Diaphragmatic Hernia. Breastfeed Med. 2019 Jun;14(5):320-324. doi: 10.1089/bfm.2019.0011. Epub 2019 Apr 16. PMID: 30990325

Oliver ER, DeBari SE, Adams SE, Didier RA, Horii SC, Victoria T, Hedrick HL, Adzick NS, Howell LJ, Moldenhauer JS, Coleman BG. Congenital diaphragmatic hernia sacs: prenatal imaging and associated postnatal outcomes. Pediatr Radiol. 2019 May;49(5):593-599. doi: 10.1007/s00247-018-04334-9. Epub 2019 Jan 11. PMID: 30635693

Lawrence KM, Berger K, Herkert L, Franciscovich C, O'Dea CLH, Waqar LN, Partridge E, Hanna BD, Peranteau WH, Avitabile CM, Hopper RK, Rintoul NE, Hedrick HL. Use of prostaglandin E1 to treat pulmonary hypertension in congenital diaphragmatic hernia.  J Pediatr Surg. 2019 Jan;54(1):55-59. doi: 10.1016/j.jpedsurg.2018.10.039. Epub 2018 Oct 5. PMID: 30442461

Jaimes C, Delgado J, Cunnane MB, Hedrick HL, Adzick NS, Gee MS, Victoria T. Does 3-T fetal MRI induce adverse acoustic effects in the neonate? A preliminary study comparing postnatal auditory test performance of fetuses scanned at 1.5 and 3 T. Pediatr Radiol. 2019 Jan;49(1):37-45. doi: 10.1007/s00247-018-4261-2. Epub 2018 Oct 8.
PMID: 30298210

Didier RA, DeBari SE, Oliver ER, Gebb JS, Howell LJ, Hedrick HL, Adzick NS, Coleman BG. Secondary Imaging Findings Aid in Prenatal Diagnosis and Characterization of Congenital Diaphragmatic Hernia: Role of an Abnormal Orientation of Vascular Structures and Gallbladder Position. J Ultrasound Med. 2019 Jun;38(6):1449-1456. doi: 10.1002/jum.14823. Epub 2018 Sep 23. PMID: 30244484 

Extracorporeal membrane oxygenation and bloodstream infection in congenital diaphragmatic hernia. Keene S, Grover TR, Murthy K, Pallotto EK, Brozanski B, Gien J, Zaniletti I, Johnson YR, Seabrook RB, Porta NFM, Haberman B, DiGeronimo R, Rintoul N; Children’s Hospitals Neonatal Consortium’s (CHNC) Congenital Diaphragmatic Hernia Focus Group. J Perinatol. 2019 Oct;39(10):1384-1391. doi: 10.1038/s41372-019-0435-5. Epub 2019 Aug 5. PMID: 31383944

Autism spectrum disorder and neurodevelopmental delays in children with giant omphalocele. Danzer E, Hoffman C, Miller JS, D'Agostino JA, Schindewolf EM, Gerdes M, Bernbaum J, Adams SE, Rintoul NE, Herkert LM, Taylor L, Schreiber J, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. J Pediatr Surg. 2019 Sep;54(9):1771-1777. doi: 10.1016/j.jpedsurg.2019.05.017. Epub 2019 May 28. PMID: 31196668

Congenital diaphragmatic hernia sacs: prenatal imaging and associated postnatal outcomes. Oliver ER, DeBari SE, Adams SE, Didier RA, Horii SC, Victoria T, Hedrick HL, Adzick NS, Howell LJ, Moldenhauer JS, Coleman BG. Pediatr Radiol. 2019 Jan 11. doi: 10.1007/s00247-018-04334-9. [Epub ahead of print]

2018

Predicting Risk of Infection in Infants with Congenital Diaphragmatic Hernia. Murthy K, Porta NFM, Pallotto EK, Rintoul N, Keene S, Chicoine L, Gien J, Brozanski BS, Johnson YR, Haberman B, DiGeronimo R, Zaniletti I, Grover TR; Children's Hospitals Neonatal Consortium (CHNC) Congenital Diaphragmatic Hernia Focus Group. J Pediatr. 2018 Dec;203:101-107.e2. doi: 10.1016/j.jpeds.2018.07.032. Epub 2018 Sep 11. PMID: 30217691

Reduced oxygen concentration for the resuscitation of infants with congenital diaphragmatic hernia. Riley JS, Antiel RM, Rintoul NE, Ades AM, Waqar LN, Lin N, Herkert LM, D'Agostino JA, Hoffman C, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. J Perinatol. 2018 Jul;38(7):834-843. doi: 10.1038/s41372-017-0031-5. Epub 2018 Jun 11. PMID: 29887609

Danzer E, Hoffman C, D'Agostino J, Ryan M, Gerdes M, Bernbaum J, Rintoul NE, Herkert LM, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Rate and risk factors associated with autism spectrum disorder in congenital diaphragmatic hernia.  Journal of Autism and Developmental Disorders 48:2112-2121, 2018. 

Danzer E, Hoffman C, D'Agostino J, Connelly JT, Waqar LN, Gerdes M, Bernbaum J, Rintoul NE, Herkert LM, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Short-term neurodevelopmental outcome in congenital diaphragmatic hernia: The impact of extracorporeal membrane oxygenation and timing of repair. Pediatric Critical Care Medicine 19:64-74, 2018.

Lawrence KM, Berger K, Herkert L, Franciscovich C, O'Dea CLH, Waqar LN, Partridge E, Hanna BD, Peranteau WH, Avitabile CM, Hopper RK, Rintoul NE, Hedrick HL. Use of prostaglandin E1 to treat pulmonary hypertension in congenital diaphragmatic hernia. J Pediatr Surg. 2018 Oct 5;. PMID: 30442461 

Didier RA, DeBari SE, Oliver ER, Gebb JS, Howell LJ, Hedrick HL, Adzick NS, Coleman BG. Secondary Imaging Findings Aid in Prenatal Diagnosis and Characterization of Congenital Diaphragmatic Hernia: Role of an Abnormal Orientation of Vascular Structures and Gallbladder Position. J Ultrasound Med. 2018 Sep 23;. [Epub ahead of print] PMID: 30244484

Riley JS, Antiel RM, Rintoul NE, Ades AM, Waqar LN, Lin N, Herkert LM, D'Agostino JA, Hoffman C, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Reduced oxygen concentration for the resuscitation of infants with congenital diaphragmatic hernia. J Perinatol. 2018 Jun 11. [Epub ahead of print]

Lawrence KM, Hedrick HL, Monk HM, Herkert L, Waqar LN, Hanna BD, Peranteau WH, Rintoul NE, Hopper RK. Treprostinil Improves Persistent Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia. J Pediatr. 2018 May 18. [Epub ahead of print] PMID: 29784517

Partridge EA, Davey MG, Hornick M, Dysart KC, Olive A, Caskey R, Connelly JT, Hedrick HL, Peranteau WH, Flake AW. Pumpless arteriovenous extracorporeal membrane oxygenation: A novel mode of respiratory support in a lamb model of congenital diaphragmatic hernia. J Pediatr Surg. 2018 Mar 9;. [Epub ahead of print] PMID: 29605270 

2017

Burgos CM, Davey MG, Riley JS, Jia H, Flake AW, Peranteau WH. Lung function and pulmonary artery blood flow following prenatal maternal retinoic acid and imatinib in the nitrofen model of congenital diaphragmatic hernia. J Pediatr Surg. 2018 Sep;53(9):1681-1687. Epub 2017 Dec 19.

Victoria T, Danzer E, Oliver ER, Edgar JC, DeBari SE, Partridge EA, Johnson AM, Peranteau WH, Coleman BG, Flake AW, Johnson MP, Hedrick H, Adzick NS. Right Congenital Diaphragmatic Hernias: Is There a Correlation between Prenatal Lung Volume and Postnatal Survival, as in Isolated Left Diaphragmatic Hernias? Fetal Diagn Ther. 2017 Mar 21. Doi:10.1159/000464246. [Epub ahead of print]

Danzer E, Hoffman C, D’Agostino JA, Gerdes M, Bernbaum J, Antiel RM, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcomes at 5 years of age in congenital diaphragmatic hernia. J Pediatr Surg. 2017 Mar;52(3):437-443.

Unolt M, DiCairano L, Schlechtweg K, Barry J, Howell L, Kasperski S, Nance M, Adzick NS, Zackai EH, McDonald-McGinn DM. Congenital diaphragmatic hernia in 22q11.2 deletion syndrome. Am J Med Genet A. 2017 Jan;173(1):135-142.

2016

Burgos CM, Pearson EG, Davey M, Riley J, Jia H, Laje P, Flake AW, Peranteau WH. Improved pulmonary function in the nitrofen model of congenital diaphragmatic hernia following prenatal maternal dexamethasone and/or sildenafil. Pediatr Res. 2016 Oct;80(4):577-85.

Unolt M, DiCairano L, Schlechtweg K, Barry J, Howell L, Kasperski S, Nance M, Adzick NS, Zackai EH, McDonald-McGinn DM. Congenital diaphragmatic hernia in 22q11.2 deletion syndrome. Am J Med Genet A. 2016 Sep 28. doi: 10.1002/ajmg.a.37980.

Danzer E, Hoffman C, D'Agostino JA, Gerdes M, Bernbaum J, Antiel RM, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcomes at 5 years of age in congenital diaphragmatic hernia. J Pediatr Surg. 2016 Aug 30. pii: S0022-3468(16)30284-6. doi: 10.1016/j.jpedsurg.2016.08.008.

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Younger gestational age is associated with increased risk of adverse neurodevelopmental outcome during infancy in congenital diaphragmatic hernia. J Pediatr Surg. 2016 Jan 5.

Antiel RM, Riley JS, Cahill PJ, Campbell RM, Waqar L, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Management and outcomes of scoliosis in children with congenital diaphragmatic hernia. J Pediatr Surg. 2016;51(12):1921-1925.

2015

Kinsella JP, Steinhorn RH, Krishnan US, Feinstein JA, Adatia I, Austin ED, Rosenzweig EB, Everett AD, Fineman JR, Hanna BD, Hopper RK, Humpl T, Ivy DD, Keller RL, Mullen MP, Raj JU, Wessel DL, Abman SH.Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension. J Pediatr. 2016 Mar;170:312-4. doi: 10.1016/j.jpeds.2015.11.050. Epub 2015 Dec 15. No abstract available. PMID: 26703869

Laje P, Hedrick HL, Flake AW, Adzick NS, Peranteau WH. Delayed abdominal closure after congenital diaphragmatic hernia repair. J Pediatr Surg. 2015 Nov 11

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Herkert L, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcome at one year of age in congenital diaphragmatic hernia infants not treated with extracorporeal membrane oxygenation. J Pediatr Surg. 2015 Jun;50(6):898-903. doi: 10.1016. Read the abstract. 

Partridge EA, Peranteau WH, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Timing of repair of congenital diaphragmatic hernia in patients supported by extracorporeal membrane oxygenation (ECMO). J Pediatr Surg. 2015 Feb;50(2):260-2. Read the abstract.

Partridge EA, Hanna BD, Rintoul NE, Herkert L, Flake AW, Adzick NS, Hedrick HL, Peranteau WH. Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia. J Pediatr Surg. 2015 Feb;50(2):263-6. Read the abstract.

2014

Danzer E, Hedrick HL. Controversies in the management of severe congenital diaphragmatic hernia. Semin Fetal Neonatal Med. 2014 Dec;19(6):376-384. Epub 2014 Nov 7. Read the abstract.

Panitch HB, Weiner DJ, Feng R, Perez MR, Healy F, McDonough JM, Rintoul N, Hedrick HL. Lung function over the first 3 years of life in children with congenital diaphragmatic hernia. Pediatr Pulmonol. 2014 Jul 10. [Epub ahead of print] Read the abstract.

Partridge EA, Bridge C, Donaher JG, Herkert LM, Grill E, Danzer E, Gerdes M, Hoffman CH, D'Agostino JA, Bernbaum JC, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Incidence and factors associated with sensorineural and conductive hearing loss among survivors of congenital diaphragmatic hernia. J Pediatr Surg. 2014 Jun;49(6):890-4; discussion 894. Epub 2014 Jan 31. Read the abstract.

2013

Bebbington M, Victoria T, Danzer E, Moldenhauer J, Khalek N, Johnson M, Hedrick H, Adzick NS. Comparison of Ultrasound and MRI parameters in predicting survival in isolated left-sided Congenital Diaphragmatic Hernia: What works best? Ultrasound Obstet Gynecol. 2013 Dec 4. doi: 10.1002/uog.13271. [Epub ahead of print]

Danzer E, Gerdes M, D'Agostino JA, Hoffman C, Bernbaum J, Bebbington MW, Siegle J, Sulkowski J, Rintoul NE, Flake AW, Scott Adzick N, Hedrick HL. Longitudinal neurodevelopmental and neuromotor outcome in congenital diaphragmatic hernia patients in the first 3 years of life. J Perinatol. 2013 May 9. doi: 10.1038/jp.2013.47. [Epub ahead of print] Cited in PubMed; PMID23660581

Victoria T, Danzer E, Scott Adzick N. Use of ultrasound and MRI for evaluation of lung volumes in fetuses with isolated left congenital diaphragmatic hernia. Semin Pediatr Surg. 2013 Feb;22(1):30-6. doi: 10.1053/j.sempedsurg.2012.10.006. Cited in PubMed; PMID 23395143. Read the abstract

Hedrick HL. Management of prenatally diagnosed congenital diaphragmatic hernia. Semin Pediatr Surg. 2013 Feb;22(1):37-43. doi: 10.1053/j.sempedsurg.2012.10.007. Cited in PubMed; PMID 23395144. Read the abstract

Danzer E, Gerdes M, D'Agostino J, Partridge EA, Hoffman-Craven CH, Bernbaum J, et al. Preschool neurological assessment in congenital diaphragmatic hernia survivors: Outcome and perinatal factors associated with neurodevelopmental impairment.  Early Hum Dev. 2013 June;89(6): 393-400. Epub 2013 Jan 17. Cited in PubMed; PMID 23333410.

2012

Victoria T, Bebbington MW, Danzer E, Flake AW, Johnson MP, Dinan D, et al. Use of magnetic resonance imaging in prenatal prognosis of the fetus with isolated left congenital diaphragmatic hernia. Prenat Diagn. 2012 Aug;32(8):715-23. doi: 10.1002/pd.3890. Epub 2012 Jun 5.

Froh EB, Spatz DL. Associated morbidities to congenital diaphragmatic hernia and a relationship to human milk. Adv Neonatal Care. 2012 Aug;12(4):209-16.

Tsai J, Sulkowski J, Adzick NS, Hedrick HL, Flake AW. Patch repair for congenital diaphragmatic hernia: is it really a problem? J Pediatr Surg. 2012 Apr;47(4):637-41.

Danzer E, Zarnow D, Gerdes M, D'Agostino JA, Siegle J, Bebbington MW, Flake AW, Adzick NS, Hedrick HL. Abnormal brain development and maturation on magnetic resonance imaging in survivors of severe congenital diaphragmatic hernia. J Pediatr Surg. 2012 Mar;47(3):453-61.

2011

Beck V, Davey MG, Mayer S, Froyen G, Deckx S, Klaritsch P, et al. A longer tracheal occlusion period results in increased lung growth in the nitrofen rat model. Prenat Diagn. 2012 Jan;32(1):39-44. doi: 10.1002/pd.2881. Epub 2011 Nov 3. Cited in PubMed; PMID 22052745.

Danzer E, Hedrick HL. Neurodevelopmental and neurofunctional outcomes in children with congenital diaphragmatic hernia. Early Hum Dev. 2011 Sep;87(9):625-32. Epub 2011 Jun 2. Review. Cited in PubMed; PMID 21640525. 

Davey MG, Zoltick PW, Todorow CA, Limberis MP, Ruchelli ED, Hedrick HL, et al. Jaagsiekte sheep retrovirus pseudotyped lentiviral vector-mediated gene transfer to fetal ovine lung. Gene Ther. 2012 Feb;19(2):201-9. doi: 10.1038/gt.2011.83. Epub 2011 Jun 9. Cited in PubMed; PMID 21654824.

Davey MG, Flake AW. Genetic therapy for the fetus: a once in a lifetime opportunity. Hum Gene Ther. 2011 Apr;22(4):383-5. Cited in PubMed; PMID 21486158.

Deprest J, Nicolaides K, Done E, Lewi P, Barki G, Largen E, DeKoninck P, Sandaite I, Ville Y, Benachi A, Jani J, Amat-Rolden I, Gratacos E. Technical aspects of fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia. J Pediatr Surg. 2011;46(1):22-32.

2010 

Danzer E, Gerdes M, Bernbaum J, D'Agostino J, Bebbington MW, Siegle J, et al. Neurodevelopmental outcome of infants with congenital diaphragmatic hernia prospectively enrolled in an interdisciplinary follow-up program. J Pediatr Surg. 2010 Sep;45(9):1759-66. Cited in PubMed; PMID 20850617.

Hedrick HL. Management of prenatally diagnosed congenital diaphragmatic hernia. [Review] Seminars in Fetal & Neonatal Medicine 15(1):21-27, Feb. 2010.

2009

Hedrick HL. Management of prenatally diagnosed congenital diaphragmatic hernia. Semin Fetal Neonatal Med. 2010 Feb;15(1):21-7. Epub 2009 Nov 2. Cited in PubMed; PMID 19884051.

Deprest JA, Hyett JA, Flake AW, Nicolaides K, Gratacos E. Current controversies in prenatal diagnosis 4: Should fetal surgery be done in all cases of severe diaphragmatic hernia? Prenat Diagn. 2009 Jan;29(1):15-9. Cited in PubMed; PMID 19125386. (No Abstract Available)

2008

Danzer E, Davey MG, Kreiger PA, Ruchelli ED, Johnson MP, Adzick NS, et al. Fetal tracheal occlusion for severe congenital diaphragmatic hernia in humans: A morphometric study of lung parenchyma and muscularization of pulmonary arterioles. J Pediatr Surg. 2008 Oct;43(10):1767-75. Cited in PubMed; PMID 18926205.

Biard JM, Schwarz U, Davey MG, Danzer E, Johnson MP, Flake AW, et al. Main bronchus occlusion for treatment of congenital diaphragmatic hernia in fetal lambs. J Pediatr Surg. 2008 Apr;43(4):620-6. Cited in PubMed; PMID 18405706.

Chiu P, Hedrick HL. Postnatal management and long-term outcomes for survivors with congenital diaphragmatic hernia. Prenatal Diagnosis 2008 Jul; 28: 592-603. Cited in PubMed; PMID 18551724.

2007

Davey M, Shegu S, Danzer E, Ruchelli E, Adzick S, Flake A, et al. Pulmonary arteriole muscularization in lambs with diaphragmatic hernia after combined tracheal occlusion/glucocorticoid therapy. Am J Obstet Gynecol. 2007 Oct;197(4):381.e1-7. Cited in PubMed; PMID 17904968.

Hedrick HL, Danzer E, Merchant A, Bebbington MW, Zhao H, Flake AW, et al. Liver Position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic hernia. Am J Obstet Gynecol. 2007 Oct;197(4):422.e1-4. Cited in PubMed; PMID 17904987. 

2005

Davey MG, Biard JM, Robinson L, Tsai J, Schwarz U, Danzer E, et al. Surfactant protein expression is increased in the ipsilateral but not contralateral lungs of fetal sheep with left-sided diaphragmatic hernia. Pediatr Pulmonol. 2005 Apr;39(4):359-67. Cited in PubMed; PMID 15704191. 

2004

Hedrick HL, Crombleholme TM, Flake AW, Nance ML, von Allmen D, Howell LJ, et al. Right congenital diaphragmatic hernia: prenatal assessment and outcomes. J Pediatr Surg 2004 Mar; 39(3): 319-323. Cited in PubMed; PMID 15017545. 

2003

Correia Pinto J, Baptista MJ, Pedrosa C, Estevão-Costa J, Flake AW, Leite-Moreira AF. Fetal heart development in the nitrofen-induced CDH rat model: The role of mechanical and non-mechanical factors. J Pediatr Surg. 2003 Oct; 38:1444-1451. Cited in PubMed; PMID 14577066. .

Davey MG, Hedrick HL, Bouchard S. Adzick NS, Flake AW, Doolin EJ. Computer-assisted sterology: Point fraction of lung parenchyma and alveolar surface density in fetal and newborn sheep. Scanning. 2003 Jan-Feb; 25:37-44. Cited in PubMed; PMID 12627897.  

Davey MG, Hedrick HL, Bouchard S, Adzick NS, Flake AW. Temporary tracheal occlusion in fetal sheep with severe lung hypoplasia does not improve postnatal respiratory function. J App Physiol. 2003 Nov; 94:1054-1062. Cited in PubMed; PMID 8906657.
*Full Article

Kitano Y, von Allmen D, Kanai M, Adzick NS, Flake AW. Epinephrine inhibits tracheal occlusion induced lung growth in fetal sheep. Fetal Diagn Ther. 2003; Sep-Oct;18(5):333-7. Cited in PubMed; PMID 12913344. Read the abstract

Hirschl RB, Fox W, Glick PL, Greenspan J, Smith K, Thompson A, et al. A prospective, randomized trial of perfluorocarbon-induced lung growth (PILG) in newborns with congenital diaphragmatic hernia. J Pediatr Surg. 2003 Mar; 38:283-289. Cited in PubMed; PMID 12632336. Read the abstract

2002

Davey MG, Hedrick HL, Kanai M, Mendoza JM, Adzick NS, Flake AW. Pulmonary epithelial liquid absorption, expressed in relation to alveolar surface area, is reduced in fetal lambs following in utero tracheal occlusion. Pediatr Pulmonol. 2002 Oct; 34:278-286. Cited in PubMed; PMID 12205569. Read the abstract

Cohen MS, Rychik J, Bush DA, Tian ZY, Howell LJ, Long T, et al. Influence of congenital heart disease on survival in children with congenital diaphragmatic hernia. J Pediatr. 2002 Jul; 141:25-30. Cited in PubMed; PMID 12091847. Read the abstract

2001

Kanai M, Kitano Y, von Allmen D, Davies P, Adzick NS, Flake AW. Fetal tracheal occlusion in the rat model of nitrofen-induced congenital diaphragmatic hernia: tracheal occlusion reverses the arterial structural abnormality. J Pediatr Surg. 2001 Jun; 36:839-845. Cited in PubMed; PMID 11381408. Read the abstract

Kitano Y, Kanai M, Davies P, von Allmen D, Yang EY, Radu A, et al. BAPS Prize 1999: Lung growth induced by prenatal tracheal occlusion and its modifying factors: A study in the rat model of congenital diaphragmatic hernia. J Pediatr Surg. 2001 Feb 36:251-259. Cited in PubMed; PMID 11172410. Read the abstract

Kitano Y, von Allmen D, Kanai M, Quinn TM, Davies P, Kitano Y, et al. Fetal lung growth after short-term tracheal occlusion is linearly related to intratracheal pressure. Jour Appl Physiol. 2001 Feb; 90:493-500. Cited in PubMed; PMID 11160047. Read the article

2000

Flake AW, Crombleholme TM, Johnson MP, Howell LJ, Adzick NS. Treatment of severe congenital diaphragmatic hernia by fetal tracheal occlusion: Clinical experience with 15 cases. Amer Obstet Gynecol. 2000 Nov; 183: 1059-1066. Cited in PubMed; PMID 11084541. Read the abstract

Walsh DS, Hubbard AM, Olutoye OO, Howell LJ, Flake AW, Johnson MP, et al. Assessment of fetal lung volumes and liver herniation with magnetic resonance imaging in congenital diaphragmatic hernia. Am J Obstet Gynecol. 2000 Nov;183(5):1067-9. Cited in PubMed; PMID 11084542. Read the abstract

Kitano Y, Flake AW, Quinn TM, Kanai M, Davies P, Sablich TJ, et al. Lung growth induced by tracheal occlusion in the sheep is augmented by airway pressurization. J Pediatr Surg. 2000 Feb; 35:216-222. Cited in PubMed; PMID 10693668. Read the abstract

1999

Quinn TM, Sylvester KG, Kitano Y, Kitano Y, Jarrett BP, Sablich TJ, et al. TGF-b2 is increased after fetal tracheal occlusion. J Pediatr Surg. 1999 May; 34(5):701-4; discussion 704-5. Cited in PubMed; PMID 10359167. Read the abstract

1998

Sylvester KG, Rasanen J, Kitano Y, Flake AW, Crombleholme TC, Adzick NS. Tracheal occlusion reverses the high vascular impedance to flow in the fetal pulmonary circulation and normalizes it's physiologic response to oxygen at term. J Pediatr Surg. 1998 Jul; 33:1071-1076. Cited in PubMed; PMID 9694096. Read the abstract

Kitano Y, von Allmen D, Yang EY, Quinn TM, Kanai M, Adzick NS, et al. Prenatal tracheal occlusion enhances lung growth in the nitrogen induced CDH model. Surg Forum. 1998; XLIX:587-9. No abstract available.

Adzick NS, Harrison MR, Crombleholme TM, Flake AW, Howell LJ. Fetal lung lesions: Management and outcome. Am J Obstetr Gyn. 1998 Oct; 179:884-889. Cited in PubMed; PMID 9790364. Read the abstract

Kitano Y, Yang EY, von Allmen D, Quinn TM, Adzick NS, Flake AW. Tracheal occlusion in the fetal rat: A new experimental model for the study of accelerated lung growth. J Pediatr Surg. 1998 Dec; 33:1741 1745. Cited in PubMed; PMID 9869041. Read the abstract

1997

Harrison MR, Adzick NS, Bullard KM, Farrell JA, Howell LJ, Rosen MA, et al. Correction of congenital diaphragmatic hernia in utero VII: A prospective trial. J Pediatr Surg 1997 Nov; 32:1637-1642. Cited in PubMed; PMID 9396545. Read the abstract

Hubbard AM, Adzick NS, Crombleholme TM, Haselgrove JC. Left-sided congenital diaphragmatic hernia: Value of prenatal MR imaging in preparation for fetal surgery. Radiol. 1997 Jun; 203:636-640. Cited in PubMed; PMID 9169681. Read the abstract

Sylvester KG, Rasanen J, Kitano Y, Flake AW, Crombleholme TM, Adzick NS. Fetal tracheal occlusion reverses the high vascular impedance in diaphragmatic hernia. Surg Forum. 1997; XLVIII:649-651. No abstract available.

Sylvester KG, Rasanen J, Kitano Y, Flake AW, Crombleholme TM, Adzick NS. Tracheal occlusion reverses the high impedance to flow in the fetal pulmonary circulation and normalizes its physiological response to oxygen at full term. J Pediatr Surg. 1998 Jul;33(7):1071-4; discussion 1074-5. Cited in PubMed; PMID 9694096. Read the abstract

Gibbs DL, Rice HE, Farrell JA, Adzick NS, Harrison MR. Familial diaphragmatic agenesis: An autosomal-recessive syndrome with a poor prognosis. J Pediatr Surg. 1997 Feb; 32:366-368. Cited in PubMed; PMID 9044155. Read the abstract

Graf J, Gibbs D, Adzick NS, Harrison MR. Fetal hydrops following in utero tracheal occlusion. J Pediatr Surg 1997 Feb; 32:214-216. Cited in PubMed; PMID 9044124. Read the abstract

Bullard KM, Sonne J, Hawgood S, Harrison MR, Adzick NS. Tracheal ligation increases cell proliferation but decreases surfactant protein production in fetal murine lungs in vitro. J Pediatr Surg. 1997 Feb; 32:207-213. Cited in PubMed; PMID 9044123. Read the abstract

Vanderwall KJ, Kohl T, Adzick NS, Harrison MR, Silverman NH. Fetal diaphragmatic hernia: echocardiography and clinical outcome. J Pediatr Surg. 1997 Feb; 32:223-226. Cited in PubMed; PMID 9044126. Read the abstract

1996

Flake AW. Fetal surgery for congenital diaphragmatic hernia. Semin Pediatr Surg. 1996 Nov;5(4):266-74. Cited in PubMed; PMID 8936656. Read the abstract

Metkus AP, Filly RA, Stringer MD, Harrison MR, Adzick NS. Sonographic predictors of survival in fetal diaphragmatic hernia. J Pediatr Surg. 1996 Jan;31(1):148-51; discussion 151-2. Cited in PubMed; PMID 8632269. Read the abstract

Vanderwall KJ, Bruch SW, Szabo Z, Meuli M, Adzick NS, Harrison MR. Fetal endoscopic ('Fetendo") tracheal clip. J Pediatr Surg. 1996 Aug;31(8):1101-3; discussion 1103-4. Cited in PubMed; PMID  8863243. Read the abstract

Harrison MR, Adzick NS, Flake AW, Vanderwall KJ, Bealer JF, Howell LJ, et al. Correction of congenital diaphragmatic hernia in utero VIII: response of the hypoplastic lung to tracheal occlusion. J Pediatr Surg. 1996 Oct;31(10):1339-48. Cited in PubMed; PMID 8906657. Read the abstract

Skarsgard ED, Meuli M, VanderWall KJ, Bealer JF, Adzick NS, Harrison M. Fetal endoscopic tracheal occlusion ("Fetendo-Plug") for congenital diaphragmatic hernia. J Pediatr Surg. 1996 Oct;31(10):1339-48. Cited in PubMed; PMID 8906657. Read the abstract

1995

Stringer MD, Goldstein RB, Filly RA, Howell LJ, Sola A, Adzick NS, et al. Fetal diaphragmatic hernia without visceral herniation. J Pediatr Surg. 1995 Sep;30(9):1264-6. Cited in PubMed; PMID 8523221. Read the abstract

Bootstaylor BS, Filly RA, Harrison MR, Adzick NS. Prenatal sonographic predictors of liver herniation in congenital diaphragmatic hernia. J Ultrasound Med. 1995 Jul;14(7):515-20. Cited in PubMed; PMID 7563299. Read the abstract

Bealer JF, Skarsgard ED, Hedrick MH, Meuli M, VanderWall KJ, Flake AW, et al. Prenatal sonographic predictors of liver herniation in congenital diaphragmatic hernia. J Pediatr Surg 1995; 30:361-365. No abstract available.

Luet'ic T, Crombleholme TM, Semple JP, D'Alton ME. Early prenatal diagnosis of bronchopulmonary sequestration with associated diaphragmatic hernia. J Ultrasound Med. 1995 Jul;14(7):533-5. Cited in PubMed; PMID 7563302. No abstract available.

Metkus AP, Harrison MR, Sola A, Adzick NS: Cost per anomaly (CPA): What does a diaphragmatic hernia cost? J Pediatr Surg 30:226-230, 1995.

1994

Hill AC, Adzick NS, Stevens MB, Mori H, Husseini W, Heymann MA. Fetal lamb pulmonary hypoplasia: pulmonary vascular and myocardial abnormalities. Thorac Surg. 1994 Apr;57(4):946-51. Cited in PubMed; PMID 8166547. Read the abstract

MacGillivray TE, Jennings RW, Rudolph AM, Ring EJ, Adzick NS, Harrison MR. Vascular changes with in utero correction of diaphragmatic hernia. J Pediatr Surg. 1994 Aug;29(8):992-6. Cited in PubMed; PMID 7965536. Read the abstract

Sullivan KM, Hawgood S, Flake AW, Harrison MR, Adzick NS. Amniotic fluid phospholipid analysis in the congenital diaphragmatic hernia fetus. J Pediatr Surg. 1994 Aug;29(8):1020-3; discussion 1023-4. Cited in PubMed; PMID 7965499. Read the abstract

Harrison MR, Adzick NS, Estes JM, Howell LJ. A prospective study of the outcome for fetuses with diaphragmatic hernia. A. 1994 Feb 2;271(5):382-4. Cited in PubMed; PMID 8054005. Read the abstract

Hedrick MH, Estes JM, Sullivan KM, Bealer JF, Kitterman JA, Flake AW, et al. Plug the lung until it grows (PLUG): A new method to treat congenital diaphragmatic hernia in the fetus. J Pediatr Surg. 1994 May;29(5):612-7. Cited in PubMed; PMID 8035268. Read the abstract

1993

Harrison MR, Adzick NS, Flake AW, Jennings RW. The CDH two-step: A dance of necessity. J Pediatr Surg. 1993 Jun; 28:813-816. Cited in PubMed; PMID 8331509. Read the abstract

Harrison MR, Adzick NS, Flake AW, Jennings RW, Estes JM, MacGillivray TE, et al. Correction of congenital diaphragmatic hernia in utero: VI. Hard-earned lessons. J Pediatr Surg. 1993 Oct; 28:1411-1418. Cited in PubMed; PMID 8263712. Read the abstract

Harrison MR, Adzick NS, Flake AW. Congenital diaphragmatic hernia: An unsolved problem. Seminars in Pediatr Surg. 1993 May; 2:109-112.  Cited in PubMed; PMID 8062027. Read the abstract

Hedrick MH, Estes JM, Sullivan KM, Bealer JF, Flake AW, Adzick NS, et al. Plug the lung until it grows (PLUG): A new method to treat congenital diaphragmatic hernia in the fetus. Surg Forum. 1993 44:644-646. No abstract available. 

1992

Jennings RW, MacGillivary TE, Rudolph AM, Ring EJ, Adzick NS, Harrison MR. Vascular considerations in correction of congenital diaphragmatic hernia. Surg Forum. 1992; 43:624-31. No abstract available.

Adzick NS. On the horizon: neonatal lung transplantation. Arch Dis Child. 1992 Apr; 67:455-7. Cited in PubMed; PMCID: PMC1590489. Read the article

Jennings RW, Lorenz HP, Duncan BW, Bradley SM, Harrison MR, Adzick NS. Adult-to-neonate lung transplantation: anatomic considerations. J Pediatr Surg. 1992 Oct; 27:1329-33. Cited in PubMed; PMID 1403504. Read the abstract

1991

Crombleholme TM, Adzick NS, Hardy K, Longaker MT, Duncan BW, Harrison MR. Pulmonary lobar transplantation in neonatal swine: a model for the treatment of diaphragmatic hernia. Current Surgery. 1991; 48:148-149. No abstract available.

1990

Crombleholme TM, Adzick NS, Longaker MT, Duncan BW, Harrison MR. Reduced size lung transplantation in neonatal swine: technique and short-term physiologic response. Ann Thorac Surg. 1990 Jan; 49:55-60. Cited in PubMed; PMID 2297276. Read the abstract

Crombleholme TM, Adzick NS, Hardy K, Longaker MT, Duncan BW, Harrison MR. Pulmonary lobar transplantation in neonatal swine: a model for treatment of congenital diaphragmatic hernia. J Pediatr Surg. 1990 Jan; 25:11-18. Cited in PubMed; PMID 2299534. Read the abstract

Crombleholme TM, Adzick NS, Longaker MT, Bradley SM, Duncan BW, Harrison MR. Pulmonary vascular resistance in neonatal swine: Response to right pulmonary artery occlusion, Isoproterenol, and Prostaglandin E1. J Pediatr Surg. 1990 Aug; 25:861-866. Cited in PubMed; PMID 2401941. Read the abstract

Harrison MR, Langer JC, Adzick NS, deLorimier AA, Golbus MS, Filly RA, et al. Correction of congenital diaphragmatic hernia in utero V: Initial clinical experience. J Pediatr Surg. 1990 Jan; 25:47-57. Cited in PubMed; PMID 2405147. Read the abstract

Harrison MR, Adzick NS, Longaker MT, Goldberg JD, Rosen MA, Filly RA, et al. Successful repair in utero of a fetal diaphragmatic hernia after removal of herniated viscera from the left thorax. N Engl J Med. 1990 May; 322:1522-1524. Cited in PubMed; PMID: 2336088.  Read the article

1989

Adzick NS, Vacanti JP, Lillehei CW, Wilson JM, O'Rourke PP, Crone RK. Fetal diaphragmatic hernia: Ultrasound diagnosis and clinical outcome in 38 cases from a single medical center. J Pediatr Surg. 1989 Jul; 24:654 658. Cited in PubMed; PMID 2666635. Read the abstract

1987

Benacerraf BR, Adzick NS. Diaphragmatic hernia: Ultrasound diagnosis and clinical outcome in 19 cases. Amer J Obstet Gynecol. 1987; 156:573-576. Cited in PubMed; PMID 3826202. Read the abstract

Langer JC, Harrison MR, Adzick NS. Congenital diaphragmatic hernia: Current controversies in prenatal and postnatal management. Fetal Ther. 1987; 2:209-215. Cited in PubMed; PMID 3509195. Read the abstract

1986

Harrison MR, Adzick NS, Nakayama DK, deLorimier AA. Fetal diaphragmatic hernia: Pathophysiology, natural history and outcome. Clin Obstet Gynecol. 1986 Aug; 29:490-501. Cited in PubMed; PMID 3757331. No abstract available.

1985

Adzick NS, Harrison MR, Glick PL, Nakayama DK, Manning FA, deLorimier AA. Diaphragmatic hernia in the fetus: Prenatal diagnosis and outcome in 94 cases. J Pediatr Surg. 1985 Aug; 20:357-361. Cited in PubMed; PMID 4045660. Read the abstract

Harrison MR, Adzick NS, Nakayama DK, deLorimier AA. Congenital diaphragmatic hernia: Fatal but fixable. Sem Perinatol. 1985; 9:103-112. Philadelphia: WB Saunders. Cited in PubMed; PMID 3898385. No abstract available.

Adzick NS, Outwater KM, Harrison MR, Reid LM. Correction of congenital diaphragmatic hernia in utero IV. An early gestational model for pulmonary vascular morphometric analysis. J Pediatr Surg 1985 Dec; 20:673-680. Cited in PubMed; PMID 4087097. Read the abstract

Chapters

MacGillivray TE, Adzick NS. Lung transplantation in pediatrics. In: Lobe T, editor. Surgical chest clinics of North America. Philadelphia: WB Saunders; 1993.

Harrison MR, Adzick NS. Experimental correction of diaphragmatic hernia. In:  Sabbagha RE, editor. Diagnostic ultrasound applied to obstetrics and gynecology, 2nd Edition. Philadelphia: J.B. Lippincott Co., 1987.