Abdominal wall defects present as a various range of anomalies from minor hernias to major abdominal protrusions. The two most common congenital defects include gastroschisis and omphalocele, which have two separate pathophysiologic origins, clinical manifestations, and management/treatment strategies. Advances in the clinical and surgical management of abdominal wall defects have greatly improved the survival of infants born with abdominal wall defects. Our research is focused on continued advances in care to help these children.

Current research studies

• Pulmonary Hypoplasia Program (PHP) Registry

Highlights

• De Bie F, Swaminathan V, Johnson G, Monos S, Adzick NS, Laje P. Long-term core outcomes of patients with simple gastroschisis. J Pediatr Surg. 2020 Sep 17:S0022-3468(20)30653-9.
• Schindewolf E, Moldenhauer JS. Genetic counseling for fetal gastrointestinal anomalies. Curr Opin Obstet Gynecol. 2020 Apr;32(2):134-139.

Prior noteworthy publications

• Danzer E, Hoffman C, Miller JS, D'Agostino JA, Schindewolf EM, Gerdes M, Bernbaum J, Adams SE, Rintoul NE, Herkert LM, Taylor L, Schreiber J, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Autism spectrum disorder and neurodevelopmental delays in children with giant omphalocele. J Pediatr Surg. 2019 Sep;54(9):1771-1777.
• Fraga MV, Laje P, Peranteau WH, Hedrick HL, Khalek N, Gebb JS, Moldenhauer JS, Johnson MP, Flake AW, Adzick NS. The influence of gestational age, mode of delivery and abdominal wall closure method on the surgical outcome of neonates with uncomplicated gastroschisis. Pediatr Surg Int. 2018 Apr;34(4):415-419.
• Victoria T, Andronikou S, Bowen D, Laje P, Weiss DA, Johnson AM, Peranteau WH, Canning DA, Adzick NS. Fetal anterior abdominal wall defects: prenatal imaging by magnetic resonance imaging. Pediatr Radiol. 2018 Apr;48(4):499-512.
• Laje P, Fraga MV, Peranteau WH, Hedrick HL, Khalek N, Gebb JS, Moldenhauer JS, Johnson MP, Flake AW, Adzick NS. Complex gastroschisis: Clinical spectrum and neonatal outcomes at a referral center. J Pediatr Surg. 2018 Oct;53(10):1904-1907.
• Partridge EA, Hanna BD, Panitch HB, Rintoul NE, Peranteau WH, Flake AW, Scott Adzick N, Hedrick HL. Pulmonary hypertension in giant omphalocele infants. J Pediatr Surg. 2014 Dec;49(12):1767-70.
• Badillo AT, Hedrick HL, Wilson RD, Danzer E, Bebbington MW, Johnson MP, Liechty KW, Flake AW, Adzick NS. Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes. J Pediatr Surg. 2008 Apr;43(4):647-53.
• Biard JM, Wilson RD, Johnson MP, Hedrick HL, Schwarz U, Flake AW, Crombleholme TM, Adzick NS. Prenatally diagnosed giant omphaloceles: short- and long-term outcomes. Prenat Diagn. 2004 Jun;24(6):434-9.
• Wilson RD, Johnson MP. Congenital abdominal wall defects: an update. Fetal Diagn Ther. 2004 Sep-Oct;19(5):385-98.