Cardiac Center Publications

International leaders in pediatric cardiac research

During the past three years, staff from the Cardiac Center have published 595 research articles, and received nearly 4,000 research citations. Here are some of our recent publications.

February 2025

Andersen KN, Yao S, White BR, Jacobwitz M, Breimann J, Jahnavi J, Schmidt A, Baker WB, Ko TS, Gaynor JW, Vossough A, Xiao R, Licht DJ, Shih EK. Cerebral Microhemorrhages in Children with Congenital Heart Disease: Prevalence, Risk Factors, and Association with Neurodevelopmental Outcomes. J Am Heart Assoc. 2025, Feb. 14(3):e035359. doi: 10.1161/JAHA.123.035359. Epub 2025 Feb 3. PMID: 39895549 **

Butters A, Arnott C, Sweeting J, Claggett B, Cuomo AS, Abrams D, Ashley EA, Day SM, Helms AS, Lampert R, Lin KY, Michels M, Miller EM, Olivotto I, Owens A, Parikh VN, Pereira AC, Rossano JW, Ryan TD, Saberi S, Stendahl JC, Ware JS, Atherton J, Semsarian C, Lakdawala NK, Ho CY, Ingles J. Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy. Circ Genom Precis Med. 2025, Feb. 18(1):e004641. doi: 10.1161/CIRCGEN.124.004641. PMID: 39851041

Butto A, Wright LK, Mao CY, Keesari R, Adams V, Chau P, Desai M, Dipchand AI, Edelson JB, Rose-Felker K, Simpson KE, Mahle WT. An Examination of Ventricular Assist Device Duration Prior to Heart Transplant in Children. Pediatr Cardiol. 2025, Feb. doi: 10.1007/s00246-025-03809-5. PMID: 39979607

Campbell K, Wallis KE, El-Messidi Hampton L, Burnham A, Mercer-Rosa L, Miller O, Mazza L, Diekroger E, Fogler J. Complex Attention-Deficit Hyperactivity Disorder in a 4-Year-Old With Repaired Critical Congenital Heart Disease and Autism Spectrum Disorder. J Dev Behav Pediatr. 2025z, Jan-Feb 01; 46(1):e83-e86. doi: 10.1097/DBP.0000000000001331. PMID: 39591526; PMCID: PMC11827680

Cianciulli AR, Sulentic A, Wang Y, Daemer M, Amin S, *Joyce J, Lasso A, Otero HJ, Cohen MS, Fuller S, Nuri MAK, Tang J, O’Byrne ML, Jolley MA. Volume Rendering of CT Images to Inform Closure of Complex Ventricular Septal Defects. JACC: Case Reports. 2025, Jan. https://doi.org/10.1016/j.jaccas.2024.102827

Dearani JA, Mavroudis C. The Emerging Influence of Artificial Intelligence on Traditional Medical Textbooks. Ann Thorac Surg. 2025, Jan. S0003-4975(25)00085-2. doi: 10.1016/j.athoracsur.2025.01.018. PMID: 39892844

Duran SR, Winder M, Reeder RW, Plummer ST, Sznycer-Taub N, Savoca M, DiMaria MV, Gordon EE, Bhaskar P, Raymond TT, Das A, Tortorich A, Lyman A, Bertrandt RA, Kozyak BW, Frank DU, Greiten LE, Bailly DK, Lay AS. Pleural Drainage, Clinical Characteristics, and Management Strategies in the Perioperative Fontan Patient: A Multicenter Report. Pediatr Cardiol. 2025, Jan. doi: 10.1007/s00246-024-03744-x. PMID: 39838190

Goldberg DJ, Costello A, Goldstein BH. Is It Safe to Exhale? JAMA Pediatr. 2025, Jan. doi: 10.1001/jamapediatrics.2024.5474. PMID: 39804639

Hames DL, Abbas Q, Asfari A, Borasino S, Diddle JW, Gazit AZ, Lipsitz S, Marshall A, Reise K, Guerineau LR, Wolovits JS, Salvin JW. Extubation Failure in Neonates Following Congenital Cardiac Surgery: Multicenter Retrospective Cohort, 2017-2020. Pediatr Crit Care Med. 2025, Feb. doi: 10.1097/PCC.0000000000003703. PMID: 39927824

King-Dowling S, Harris S, Daniel LC, Kwan MYW, Ginsberg JP, Goldmuntz E, Szalda D, Schwartz LA. A pilot study of device-assessed physical activity and ecological momentary assessment among adolescent and young adult survivors of childhood cancer. Ann Behav Med. 2025, Jan. 59(1):kaaf002. doi: 10.1093/abm/kaaf002. PMID: 39898877

Kiskaddon AL, Do NL, Amankwah EK, Witt DM, Ignjatovic V, Giglia TM, Woods GM, Whitworth HB, Stock AC, Goldenberg NA. Arterial thromboembolism, antithrombotic therapy, and risk of recurrent thromboembolism in children with CHD undergoing cardiac surgery. Cardiol Young. 2025, Feb. 1-4. doi: 10.1017/S1047951125001271. PMID: 40012325

Kuiper JR, Bembea M, Gaynor JW, Graham D, Graham EM, Kannan K, Posnack NG, Everett AD, Buckley JP. Exposed and Vulnerable: Sources and Health Implications of Chemical Exposures in Neonatal, Pediatric, and Cardiac Intensive Care Units. Curr Environ Health Rep. 2025 Feb. 12(1):11. doi: 10.1007/s40572-025-00477-8. PMID: 39951231

Mayer A, Brandon TG, Aggarwal A, Burgos-Vargas R, Colbert RA, Horneff G, Joos R, Laxer RM, Minden K, Ravelli A, Ruperto N, Smith JA, Stoll ML, Tse SM, Van den Bosch F, Maksymowych WP, Lambert RG, Biko DM, Chauvin NA, Francavilla ML, Jaremko JL, Herregods N, Kasapcopur O, Yildiz M, Srinivasalu H, Faerber JA, Naden R, Hendry AM, Weiss PF. Effect of Characteristic Inflammatory and Structural Pelvic Magnetic Resonance Imaging Lesions on Expert Assessment of Axial Juvenile Spondyloarthritis. J Rheumatol. 2025, Feb. 52(2):165-172. doi: 10.3899/jrheum.2024- 0696. PMID: 39814440; PMCID: PMC11788049 **

Padiyath A, Lynch JM, Montenegro LM, Nicolson SC, Nelson O, Szwast AL, Shillingford AJ, Falkensammer CB, Savla JJ, Moldenhauer J, Khalek N, Rychik J. Transitioning from the safety of the womb to the outside world for neonates with life-threatening cardiovascular conditions: The IMmediate Postpartum Access to Cardiac Therapy (IMPACT) Procedure. Pediatr Cardiol. 2025, Jan. doi: 10.1007/s00246-025-03775-y.. PMID: 39833300

Thompson EW, Dong NJ, Kim JS, Bhattaru A, Vu P, Hu F, Shinohara RT, Swago S, Donnelly E, Zhang X, Loth A, Vuthuri L, Lanzilotta K, Whitehead KK, Duda J, Gee J, Almasy L, Goldmuntz E, Fogel MA, Witschey WR. Cardiovascular Magnetic Resonance Imaging Traits Associated with Adverse Right Ventricular Remodeling in Repaired Tetralogy of Fallot. J Cardiovasc Magn Reson. 2025, Feb. 101855. doi: 10.1016/j.jocmr.2025.101855. PMID: 39947483

Schmitt C, Beasley G, Guerrier K, Kramer J, Naim MY, Griffis H, McNally B, Chan PS, Al- Araji R, Rossano J. COVID-19 and pediatric out-of-hospital cardiac arrest using U.S. registry database. Resusc Plus. 2025, Jan. 22:100869. doi: 10.1016/j.resplu.2025.100869. PMID: 39926360; PMCID: PMC11803234 **

Wang JY, Michki SN, Sitaraman S, Banaschewski BJ, Jamal R, Gokey JJ, Lin SM, Katzen JB, Basil MC, Cantu E, Kropski JA, Zepp JA, Frank DB, Young LR. Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome. JCI Insight. 2024, Dec. 10(3):e183483. doi: 10.1172/jci.insight.183483. PMID: 39699958

January 2025

Barry OM, Hasan BS, Aslam N, Batlivala SP, Crystal MA, Trucco SM, Gudausky T, Holzer RJ, Kreutzer J, Nicholson G, O’Byrne ML, Quinn BP, Reddy SRV, Salavitabar A, Boe B. Evaluating Procedural Performance: A Composite Outcome for Atrial Septal Defect and Patent Ductus Arteriosus Closures. Journal of the Society for Cardiovascular Angiography & Interventions. 2025, Jan. doi: 10.1016/j.jscai.2024.102459

Butters A, Arnott C, Sweeting J, Claggett B, Cuomo A, Abrams D, Ashley EA, Day SM, Helms AS, Lampert R, Lin K, Michels M, Miller EM, Olivotto I, Owens A, Parikh VN, Pereira AC, Rossano JW, Ryan TD, Saberi S, Stendahl JC, Ware JS, Atherton J, Semsarian C, Lakdawala NK, Ho CY, Ingles J. Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy. Circ Genom Precis Med. 2025, Jan. e004641. doi: 10.1161/CIRCGEN.124.004641. Epub ahead of print. PMID: 39851041

Colello SS, Ittenbach RF, Klepczynski B, Mangeot C, Burnham N, Messersmith A, Kim YY, Gaynor JW, Lewey J. Cardiovascular Disease Among Women and Birthing Individuals After Delivering a Child With Congenital Heart Disease. JACC Adv. 2024, Dec. 4(1):101434. doi: 10.1016/j.jacadv.2024.101434. PMID: 39720582; PMCID: PMC11666928

DiGregorio H, Mansoorshahi S, Carlisle SG, Tovar Pensa C, Watts A, McNeely C, Sabate- Rotes A, Yetman A, Michelena HI, De Backer JFA, Mosquera LM, Bissell MM, Andreassi MG, Foffa I, Hui DS, Caffarelli A, Kim YY, Citro R, De Marco M, Tretter JT, McBride KL, Body SC, Milewicz DM, Prakash SK; EBAV Investigators. Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve. Heart. 2024, Dec 10: heartjnl-2024-324669. doi: 10.1136/heartjnl-2024-324669. PMID: 39658198

Edelson JB, Raskin A, Absi M, Adachi I, Aljohani O, Alzubi A, Amdani S, Asante-Korang A, Auerbach S, Bansal N, Bearl D, Boucek K, Butto A, Butts R, Byrnes J, Castleberry C, Conway J, Do N, Dykes J, Friedland-Little J, Greiten L, Henderson H, Hsu D, Jeewa A, Joong A, Khan S, Knoll C, Lantz J, Law S, Lorts A, Maeda K, Martinez H, May L, Mehegan M, Mokshagundam D, Montgomery C, O'Connor M, Parent JJ, Peng DM, Rosenthal DN, Sheybani A, Shezad M, Shugh L, Shwaish N, Spinner J, Su J, Sutcliffe D, Tunuguntla H, VanderPluym C, Vaughn G, Wallis G, Wilkens S, Zinn M, Niebler R; ACTION collaborators. The ACTION VAD registry: A collective five-year experience. J Heart Lung Transplant. 2025, Jan 17:S1053-2498(25)00010-5. doi: 10.1016/j.healun.2025.01.007. Epub ahead of print. PMID: 39827929

Essaid L, Haque K, Shillingford A, Zimmerman L, Burnham A, Hampton L, Okunowo O, Gaynor JW, Abend NS, Naim MY, Gardner MM. Medical & Socioeconomic Risk Factors Associated with Lack of Neurodevelopmental Evaluation Following Neonatal Cardiac Surgery. Pediatr Cardiol. 2025, Jan. doi: 10.1007/s00246-024-03761-w. Epub ahead of print. PMID: 39755847

Hill GD, Hahn E, Block JR, Chaves AH, Cumbermack K, Lipinski J, Natarajan S, Parra DA, Robinson JD, Soriano BD, Walsh MJ, Seo J, Frommelt P. Identifying Factors that Influence Pediatric Echo Lab Image Quality: Development and Validation of a New Assessment Tool. Pediatr Cardiol. 2024, Dec. doi: 10.1007/s00246-024-03763-8. PMID: 39738807

Griffiths ER, Profsky MP, Mokshagundam D, Boucek K, Amdani S, Davies RR, Monge MC, Morales DL, Rossano JW, Jacobs JP, Kirklin JK, Koehl D, Cantor R, Peng DM; Pedimacs Investigators. Eighth Annual Society of Thoracic Surgeons Pedimacs Report. Ann Thorac Surg. 2025, Jan 14:S0003-4975(25)00009-8. doi: 10.1016/j.athoracsur.2024.12.020. Epub ahead of print. PMID: 39818264

*Gupta M, Leeth EB, Barak-Corren Y, Gartenberg AJ, Silvestro E, O'Byrne ML, Callahan R. Balloon Dilation Technique Influences Stent Shortening and Intentional Stent Fracture During Overexpansion of Drug-Eluting Stents: A Bench-Testing Study. Catheter Cardiovasc Interv. 2025, Jan. doi: 10.1002/ccd.31428. Epub ahead of print. PMID: 39887520

Gusseva M, Thatte N, Castellanos DA, Hammer PE, Ghelani SJ, Callahan R, Hussain T, Chabiniok R. Biomechanical modeling combined with pressure-volume loop analysis to aid surgical planning in patients with complex congenital heart disease. Med Image Anal. 2024, Dec. 101:103441. doi: 10.1016/j.media.2024.103441. PMID: 39709691

*Josowitz R, Ho DY, Shankar S, Mondal A, Zavez A, Linn RL, Tian Z, Gaynor JW, Rychik J. Congenital Heart Disease Fetuses Have Decreased Mid-Gestational Placental Flow, Placental Malperfusion Defects, and Impaired Growth. JACC Adv. 2025 Jan 16; 4(2):101559. doi: 10.1016/j.jacadv.2024.101559. PMID: 39898349; PMCID: PMC11786062 **

King-Dowling S, Harris S, Daniel LC, Kwan MYW, Ginsberg J, Goldmuntz E, Szalda D, Schwartz LA. A pilot study of device-assessed physical activity and ecological momentary assessment among adolescent and young adult survivors of childhood cancer. Ann Behav Med. 2025, Jan. 59(1):kaaf002. doi: 10.1093/abm/kaaf002. PMID: 39898877

Kirschen MP, Ullman NL, Reeder RW, Ahmed T, Bell MJ, Berg RA, Burns C, Carcillo JA, Carpenter TC, Wesley Diddle J, Federman M, Fink EL, Frazier AH, Friess SH, Graham K, Horvat CM, Huard LL, Kilbaugh TJ, Maa T, Manga A, McQuillen PS, Meert KL, Morgan RW, Mourani PM, Nadkarni VM, Naim MY, Notterman D, Palmer CA, Pollack MM, Sapru A, Sharron MP, Srivastava N, Tilford B, Viteri S, Wolfe HA, Yates AR, Topjian A, Sutton RM, Press CA. Practice patterns for acquiring neuroimaging after pediatric inhospital cardiac arrest. Resuscitation. 2025, Jan 21; 207:110506. doi: 10.1016/j.resuscitation.2025.110506. Epub ahead of print. PMID: 39848427

Levine LD, Friedman AM, Kim YY, Purisch SE, Wen T. Postpartum readmissions among patients with adult congenital heart disease. Am J Obstet Gynecol MFM. 2024, Dec. 7(2):101580. doi: 10.1016/j.ajogmf.2024.101580. PMID: 39694093

Mondragon-Estrada E, Newburger JW, DePalma SR, Brueckner M, Cleveland J, Chung WK, Gelb BD, Goldmuntz E, Hagler DJ Jr, Huang H, McQuillen P, Miller TA, Panigrahy A, Porter GA Jr, Roberts AE, Rollins CK, Russell MW, Tristani-Firouzi M, Grant PE, Im K, Morton SU. Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact. iScience. 2024, Dec. 28(2):111707. doi: 10.1016/j.isci.2024.111707. PMID: 39877905; PMCID: PMC11772982

Pettit AN, Nitsche LJ, Ahmed H, Catalano M, Mavroudis CD. Orthotopic heart transplantation in patient with Williams syndrome: case report and considerations in perioperative and long-term management. Cardiol Young. 2025, Jan. 24:1-2. doi: 10.1017/S1047951124036540. Epub ahead of print. PMID: 39849891

Rees JR, Levine LD, Kim YY, McCoy JA. Cardiac and obstetric outcomes among congenital heart disease patients with repeat pregnancies. Am J Obstet Gynecol MFM. 2025, Jan. 7(2):101597. doi: 10.1016/j.ajogmf.2024.101597. PMID: 39755248

Rychik J. Commentary: Pulmonary vasodilation in the Fontan circulation: Are we searching in the wrong place to significantly improve the circulation? J Thorac Cardiovasc Surg. 2024, Dec. S0022-5223(24)01138-3. doi: 10.1016/j.jtcvs.2024.10.059. PMID: 39694457

*Wooster L, O'Connor MJ, Zhang X, Mavroudis CD, Maeda K, Ahmed H, Edwards J, Lin KY, Wittlieb-Weber C, Rossano J, Edelson JB. Impact of Heart Transplant Allocation Changes on Waitlist Mortality and Clinical Practice in Pediatric and Adult Patients with Congenital Heart Disease and Cardiomyopathy. Circulation. 2025, Jan. doi: 10.1161/CIRCULATIONAHA.124.072335. Epub ahead of print. PMID: 39781913 **

Yeh MJ, Bergersen L, Gauvreau K, Akhtar S, Batlivala SP, Bocks ML, Holzer R, O'Byrne ML, Shahanavaz S, Trucco SM, Zellers T, Armstrong AK. Association between procedure duration and adverse events in congenital cardiac catheterization. Cardiol Young. 2025, Jan. 21:1-8. doi: 10.1017/S1047951124036606. Epub ahead of print. PMID: 39834061