This study is testing the safety and effectiveness of adding a targeted therapy (ruxolitinib) to standard chemotherapy for children, adolescents, and young adults with high-risk acute lymphoblastic leukemia with CRLF2 and other JAK pathway mutations.
CHOP and the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) consortium is conducting a study for children and young adults 21 years old or younger who have relapsed or refractory acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma. This study adds the study drug 'Ixazomib' to standard relapsed ALL chemotherapy drugs. For more information about this study, including specific eligibility criteria, please visit clinicaltrials.gov and search for "NCT03817320" or visit the TACL website at https://tacl.chla.usc.edu/Tacl/#!/Page/3. To hear more about this and other available trails or get any questions answered please contact our Cancer Intake Specialist by phone at 267-426-0762 or email Oncointake@email.chop.edu.
The purpose of this study is to test if the CD19 CAR T cell product tisagenlecleucel (also referred to as CTL019, or Kymriah™) is safe and has beneficial effects in children and young adults who have newly diagnosed high-risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL) that remains MRD-positive after 2 cycles of chemotherapy. The study is enrolling children and young adults between the ages of 1-25 who have received induction and consolidation chemotherapy for HR B-ALL but were still found to have remaining disease (MRD). If you agree to join in this study, you will get one dose of the tisagenlecleucel cells administered by intravenous infusion and be followed for leukemia response. This study also involves blood draws and assessments. Reimbursement for travel may be provided. If you have questions or would like to learn more about the study, please contact the Cancer Immunotherapy Program at (215) 425-7193. The Principal Investigator is Dr. Shannon Maude and the Immunotherapy Nurse Navigator is Brooke Leibfreid, RN.
For patients (and parents of patients) that have been diagnosed with, pediatric
acute lymphoblastic leukemia (ALL), nausea and vomiting are among the most bothersome
symptoms during chemotherapy treatment.
The overall goal of this study is to find the best strategies used by parents
and patients for managing these symptoms when receiving maintenance therapy.
CHOP, in collaboration with Onyx Therapeutics, Inc., is
conducting a study for children and young adults up to 21 years old, with relapsed
or refractory acute lymphoblastic leukemia. This clinical trial is adding the
study drug, Carfilzomib, to a standard relapse chemotherapy regimen. For more
information about this study, including specific eligibility criteria, please
visit clinicaltrials.gov and search for "NCT02303821". To hear more
about this and other available trails or get any questions answered please
contact our Cancer Intake Specialist by phone at 267-426-0762 or email Oncointake@email.chop.edu.