Fetal Lung Lesion and Airway Publications

The following list of publications will help you in your search for more information about fetal lung lesions and airway obstruction, including congenital cystic adenomatoid malformation (CCAM), congenital pulmonary airway malformation (CPAM), bronchopulmonary sequestration (BPS) and congenital high airway obstruction syndrome (CHAOS). Most are written by members of the Fetal Diagnosis and Treatment team at The Children's Hospital of Philadelphia. If you are unable to obtain any of these publications, please let us know, and we will send copies to you.

Journal articles

2013

Khalek N, Johnson MP. Management of prenatally diagnosed lung lesions. Semin Pediatr Surg. 2013 Feb;22(1):24-9. doi: 10.1053/j.sempedsurg.2012.10.005. Cited in PubMed; PMID 23395142.

2012 

Gregory CL, Wright J, Schwarz J, Rakowski L. A review of fetal thoracoamniotic & vesicoamniotic shunt procedures. J Obstet Gynecol Neonatal Nurs. 2012;41(3):426-433.

Danzer E, Siegle J, D'Agostino JA, Gerdes M, Hoffman C, Bernbaum J, et al. Early neurodevelopmental outcome of infants with high-risk fetal lung lesions. Fetal Diagn Ther. 2012;31(4):210-5. Epub 2012 Apr 26.

2010

Epelman M, Kreiger PA, Servaes S, Victoria T, Hellinger JC. Current imaging of prenatally diagnosed congenital lung lesions. Semin Ultrasound CT MR. 2010 Apr;31(2):141-57.

2009

Adzick NS. Management of fetal lung lesions. Clin Perinatol.2009 Jun;36(2):363-76, x. Review.

2008

Tsai AY, Liechty KW, Hedrick HL, Bebbington M, Wilson RD, Johnson MP, Howell LJ, Flake AW, Adzick NS. Outcomes after postnatal resection of prenatally diagnosed asymptomatic cystic lung lesions. J Pediatr Surg. 2008 Mar;43(3):513-7.

Ganesh A, Adzick NS, Foster T, Cucchiaro G. Efficacy of addition of fentanyl to epidural bupivacaine on postoperative analgesia after thoracotomy for lung resection in infants. Anesthesiology. 2008 Nov;109(5):890-4.

Gonzaga S, Henriques-Coelho T, Davey M, Zoltick PW, Leite-Moreira AF, Correia-Pinto J, Flake AW. Cystic adenomatoid malformations are induced by localized FGF10 overexpression in fetal rat lung. Am J Respir Cell Mol Biol. 2008 Sep;39(3):346-55. Epub 2008 Apr 17.

Wilson RD. In utero therapy for fetal thoracic abnormalities. Prenat Diagn. 2008 Jul;28(7):619-25. Review.

Peranteau WH, Merchant AM, Hedrick HL, Liechty KW, Howell LJ, Flake AW, Wilson RD, Johnson MP, Bebbington MW, Adzick NS. Prenatal Course and Postnatal Management of Peripheral Bronchial Atresia: Association with Congenital Cystic Adenomatoid Malformation of the Lung. Fetal Diagnosis and Therapy 2008; 24:190-196.

Laje P, Liechty KW. Postnatal management and outcome of prenatally diagnosed lung lesions. Prenatal Diagnosis 2008; 28: 612-618.

Mong A, Johnson AM, Kramer SS, Coleman BG, Hedrick HL, Kreiger P, Flake A, Johnson M, Wilson RD, Adzick NS, Jaramillo D. Congenital high airway obstruction syndrome: MR/US findings, effect on management, and outcome. Pediatr Radiol. 2008 Nov;38(11):1171-9. Epub 2008 Aug 13.

2007

Mann S, Wilson RD, Bebbington MW, Adzick NS, Johnson MP; Antenatal diagnosis and management of congenital cystic adenomatoid malformation. Semin Fetal and Neonatal Med. 2007 Dec;12(6):477-81. Epub 2007 Oct 22.

Merchant AM, Peranteau W, Wilson RD, Johnson MP, Bebbington MW, Hedrick HL, Flake AW, Adzick NS. Postnatal Chest Wall Deformities after Fetal Thoracoamniotic Shunting for Congenital Cystic Adenomatoid Malformation. Fetal Diagn Ther 2007;22:435-439.

Peranteau WH, Wilson RD, Liechty KW, Johnson MP, Bebbington MW, Hedrick HL, Flake AW, Adzick NS. Effect of Maternal Betamethasone Administration on Prenatal Congenital Cystic Adenomatoid Malformation Growth and Fetal Survival. Fetal Dign Ther 2007;22:365-371.

Pressey TL, Wilson RD, Kasperski S, Bebbington MW, Adzick NS. Prenatal Diagnosis of Partial Trisomy 1q and Monosomy X in a Fetus with a Congenital Lung Lesion and Hydrops Fetalis. Am Jnl Med Gen Part A 143A: 1104-1107.

2006

Wilson RD, Pawel B, Bebbington MW, Johnson MP, Foong-Yen L, Stamillio D, Silber A, Zakai E, Flake AW. Congenital pulmonary lymphangiectasis sequence: A rare, heterogeneous, and lethal etiology for prenatal pleural effusion. Prenat Diagn 2006; 26: 1058-1061.

2005

Wilson RD, Hedrick HL, Liechty KW, Flake AW, Johnson MP, Bebbington M, Adzick NS. Prenatal Diagnosis of Partial Trisomy 1q and Monosomy X in a Fetus with a Congenital Lung Lesion and Hydrops Fetalis. Am Jnl Med Gen 140A:151-155, 2006.

Hedrick HD, Flake AW, Crombleholme TM, Howell LJ, Johnson MP, Wilson RD, Adzick NS. The ex utero intrapartum therapy procedure for high-risk fetal lung lesions. J Pediatr Surg 40: 1038-1044, 2005.

2004

RD Wilson, JK Baxter, MP Johnson, M King, S Kasperski, TM Crombleholme, AW Flake, HL Hedrick, LJ Howell, NS Adzick. Thoracoamniotic shunts: Fetal treatment of pleural effusions and congenital cystic adenomatoid malformations. Fetal Diagnosis & Therapy 2004; 19(5):413-420.

2003

Adzick NS, Flake AW, Crombleholme TM: Management of congenital lung lesions. Sem Pediatric Surgery 12:10-16, 2003.

Adzick NS: Management of fetal lung lesions. Clinics in Perinatology 30:481-492, 2003.

Lim F-Y, Crombleholme TM, Hedrick HL, Flake AW, Johnson MP, Howell LJ, Adzick NS. Congenital high airway obstruction syndrome: Natural history and management. Journal of Pediatric Surgery 38:940-945, 2003.

2002

TM Crombleholme, B Coleman, HL Hedrick, K Liechty, LJ Howell, AW Flake, MP Johnson, NS Adzick. CCAM volume ratio predicts outcome in prenatally diagnosed CCAM. J Pediatr Surg 2002; 37:331-338.

WT Mahle, ZY Tian, M Cohen, LJ Howell, MP Johnson, TM Crombleholme, NS Adzick, J Rychick. Echocardiographic evaluation of the fetus with CCAM. Ultrasound Obstet Gynecol 2002; 16:620-624.

Crombleholme TM, Coleman B, Hedrick H, Liechty K, Howell L, Flake AW, Johnson M, Adzick NS. Cystic adenomatoid malformation volume ratio predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lung. Journal of Pediatric Surgery 37:331-338, 2002.

2001

TC MacKenzie, ME Guttenberg, HL Nisenbaum, MP Johnson, NS Adzick. A fetal lung lesion consisting of bronchogenic cyst, bronchopulmonary sequestration, and congenital cystic adenomatoid malformation: the missing link? Fetal Diagn Therapy 2001; 16(4): 193-5.

2000

Mahle WT, Rychik J, Tian ZY, Cohen MS. Howell LJ, Crombleholme TM, Flake AW, Adzick NS: Echocardiographic evaluation of the fetus with congenital cystic adenomatoid malformation. Ultrasound in Obstetrics and Gynecology 15:1-6, 2000.

MacKenzie TC, Guttenberg ME, Nissenbaum HL, Johnson MP, Adzick NS: A fetal lung lesion consisting of bronchogenic cyst, bronchopulmonary sequestration, and congenital cystic adenomatoid malformation: The missing link? Fetal Diagn Ther. 2001 Jul-Aug;16(4):193-5.

Milner R, Kitano Y, Oluyinka O, Flake AW, Adzick NS: Radiofrequency thermal ablation (RTA): A potential treatment for hydropic fetuses with a large chest mass. J Pediatr Surg 35: 386-389, 2000.

Carpentieri DF, Guttenberg M, Quinn TM, Adzick NS: Subdiaphragmatic pulmonary sequestration: A case report with review of the literature. J Perinatology 1:60-62, 2000.

Olutoye O, Coleman B, Hubbard AM, Adzick NS: Prenatal diagnosis and management of congenital lobar emphysema. J Pediatr Surg 35:792-795, 2000. 

Crombleholme TM, Sylvester KG, Flake AW, Adzick NS: Salvage of a fetus with congenital high airway obstruction syndrome (CHAOS). Fetal Diagnosis and Therapy 15:280-282, 2000.

1999

Liechty KW, Quinn TM, Cass DL, Crombleholme TM, Flake AW, Adzick NS. Elevated PDGF-B in congenital cystic adenomatoid malformations (CCAMs) requiring fetal resection. Journal of Pediatric Surgery 34(5):805-811, May 1999.

Adzick NS, Harrison MR, Crombleholme TM, Flake AW, Howell LJ: Fetal Lung Lesions: Management and Outcome. Am J Obstet Gynecol. 1998 Oct;179(4):884-9.

Kitano Y, Adzick NS: New developments in fetal lung surgery. Current Opinion in Pulmonary Medicine. 5:383 389, 1999.

1998

Cass DL, Yang EY, Liechty KW, Quinn TM, Crombleholme TM, Flake AW, Adzick NS. Increased cell proliferation and decreased apoptosis in congenital cystic adenomatoid malformation: Insights into pathogenesis. Journal of Pediatric Surgery, 33:1043-1047, 1998.

Yang EY, Kim HB, Shaaban AF, Milner R, Adzick NS, Flake AW. Fetal intramuscular delivery of recombinant adenovirus results in persistent postnatal transgene expression in both muscle and liver. Surgical Forum XLIX:368-9, 1998.

Lovvorn HN, Crombleholme TM, Drott H, Flake AW, Adzick NS. Maternal colloid osmotic pressure after fetal surgery. Surgical Forum XLIX:481-2,

1997

Cass DL, Yang EY, Liechty KW, Quinn TM, Crombleholme TM, Flake AW, Adzick NS: Increased cell proliferation and decreased apoptosis in congenital cystic adenomatoid malformation: Insights into pathogenesis. Surgical Forum 48:659-661,1997.

Cha I, Adzick NS, Harrison MR, Finkbeiner WE: Fetal congenital cystic adenomatoid malformation of the lung: A clinicopathologic study of eleven cases. American J Surg Path 21:537-544, 1997.

Cass DL, Crombleholme TM, Howell LJ, Stafford PW, Adzick NS. Cystic lung lesions with systemic arterial blood supply: A hybrid of congenital cystic adenomatoid malformation and bronchopulmonary sequestration. J Pediatr Surg 32:986-990, 1997.

1996

Crombleholme, TM: Prenatal diagnosis and management of surgical pulmonary problems. Neonatal Resp Dis 6 (5), 1996.

1994

Adzick NS: Fetal cystic adenomatoid malformation. Sem Thoracic Cardiovasc Surg 6:247-252, 1994.

Rice HE, Estes JM, Hedrick MH, Bealer JF, Harrison MR, Adzick NS: Congenital cystic adenomatoid malformation: A sheep model of fetal hydrops. J Pediatr Surg 29(5):692-696, 1994.

Morin L, Crombleholme TM, D'Alton ME: Prenatal diagnosis and management of fetal thoracic lesions. Sem in Perinatol 18 (3): 228-253, 1994.

Morin L, Crombleholme TM, Louis F, D'Alton M: Bronchopulmonary sequestration: Prenatal diagnosis with clinicopathologic correlation. Curr Opin Obstet Gynecol 6 (5): 479-481, 1994.

Hedrick MH, Martinez-Ferro M, Filly RA, Flake AW, Harrison MR, Adzick NS: Prenatal diagnosis of congenital high airway obstruction (CHAOS): Potential for perinatal intervention. J Pediatr Surg 29:271-274, 1994.

1993

MacGillivray TE, Harrison MR, Goldstein RB, Adzick NS: Disappearing fetal lung lesions. J Pediatr Surg 28:1321-1325, 1993.

Adzick NS: Fetal thoracic lesions. Seminars in Pediatr Surg 2:103-108, 1993.

Adzick NS, Harrison MR, Flake AW, Howell LJ, Golbus MS, Filly RA: Fetal surgery for cystic adenomatoid malformation of the lung. J Pediatr Surg 28:806-812, 1993.

Adzick NS, Harrison MR. Management of the fetus with a cystic adenomatoid malformation. World J Surgery 17:342-349, 1993.

1992

Kuller JA, Yankowitz J, Goldberg JD, Harrison MR, Adzick NS, Filly RA, Callen PW, Golbus MS. Outcome of antenatally diagnosed cystic adenomatoid malformation. Am J Ob Gyn 167:1038-41, 1992.

1990

Harrison MR, Adzick NS, Jennings RW, Duncan BW, Rosen MA, Filly RA, Goldberg JD, deLorimier AA, Golbus MS: Antenatal intervention for congenital cystic adenomatoid malformation. Lancet 336:965-967, 1990.

1988

Fine C, Adzick NS, Doubilet PM: Decreasing size of a congenital cystic adenomatoid malformation in utero: Case report. J Ultrasound in Medicine 7:405-408, 1988.

Saltzman DH, Adzick NS, Benacerraf BR: Fetal cystic adenomatoid malformation of the lung: Apparent improvement in utero. Obstet Gynecol 71:1000-1003, 1988.

1987

Hu LM, Davies P, Adzick NS, Harrison MR, Reid LM: The effects of intrauterine pneumonectomy in lambs: A morphometric study of the remaining lung at term. Amer Rev Respir Disease 133:607-612, 1987.

1986

Adzick NS, Harrison MR, Hu LM, Davies P, Reid LM: Compensatory lung growth after pneumonectomy in fetal lambs: A morphometric study. Surg Forum 37:309-311, 1986.

1984

Adzick NS, Harrison MR, Glick PL, Golbus MS, Anderson RL, Mahoney BS, Callen PW, Hirsch JH, Luthy DA, Filly RA, deLorimier AA: Fetal cystic adenomatoid malformation. Prenatal diagnosis and natural history. J Pediatr Surg 19:649-657, 1984.

Chapters

Cass DL, Adzick NS: Fetal cystic adenomatoid malformation. In Rodeck C, Evans M (eds): Ultrasound and Fetal Therapy. Parthenon Press, New York, NY, 2000, pp. 49-60.

Adzick NS: Fetal cystic adenomatoid malformation of the lung. In Harrison MR, Golbus MS, Filly RA (eds): The Unborn Patient, 2nd Edition. WB Saunders Company, Philadelphia, pp 557-564, 1990.

Reviewed on February 20, 2013