Amaliris Guerra, PhD

female silhouette icon
Amaliris Guerra, PhD, is a post-doctoral fellow with the Division of Hematology at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Fellowship

Post-doctoral Fellow - Children’s Hospital of Philadelphia, Philadelphia, PA
Graduate Research Fellow - Temple University, Philadelphia, PA

Undergraduate Degree

BA in Biology - Temple University, Philadelphia, PA

Graduate Degree

PhD in Biology - Temple University, Philadelphia, PA

Titles and Academic Titles

Post-Doctoral Fellow

Departments and Services

Publications

Papers

2021

Pires-Lourenco, S., Jarocha, D., Ghiaccio, V., Guerra, A.,… Rivella, S. (2021) Inclusion of a shRNA targeting BCL11A into a β-globin expressing vector allows concurrent synthesis of curative adult and fetal hemoglobin. Haematologica. 106(10):2740-2745. doi:10.3324/haematol.2020.276634. PMID: 34047176

Sinha, S., Pereira-Reis, J., Guerra, A., Rivella, S., Duarte, D. (2021) The role of iron in benign and malignant hematopoiesis. Antioxidants & Redox Signaling. 35(6):415-432. doi: 10.1089/ars.2020.8155. PMID: 33231101.

Brooks, D., Guerra, A., McGill, L., Addo, T., Joseph, J., Silva-Fisher, J. (2021) Voices on diversity: Making the scientific community more inclusive. Mol Cell. 81(7):1355-1357. doi: 10.1016/j.molcel.2021.02.024. PMID: 33798409

Manning Nervo, L., Ayombil, F., Addo, T., Guerra, A., Walker, M., McGill, L., Joseph, J., Silva-Fisher, J. (2021) Voices on diversity: support systems that work. Mol Cell. 81(5):885-888. doi: 10.1016/j.molcel.2021.01.027. PMID: 33667376

McGill, L., Nervo., Brooks, D., Joseph, J., Silva-Fisher, J., Guerrier, S., Addo, T., Guerra, A., . . . Odinammadu, K. (2021) Voices of Diversity: Creating a Sense of Belonging. Mol Cell 81(2):213-217. doi: 10.1016/j.molcel.2020.12.045. PMID: 33482088

Silva-Fisher, Guerrier, S., J., Nervo L.M., Guerra, A., . . .Odinammadu, K. (2021) Voices of Diversity: Combatting Racial Inequality to Increase Diversity. Mol Cell. 81(1) 1-5 doi:10.1016/j.molcel.2020.12.022. PMID: 33417852

2019

Parrow, N. L., Li, Y., Feola, M., Guerra, A., Casu, C., Prasad, P., . . .Fleming, R. E. (2019). Lobe specificity of iron-binding to transferrin modulates murine erythropoiesis and iron homeostasis. Blood. 134(17):1373-1384. doi: 10.1182/blood.2018893099. PMID: 31434707

Guerra, A., Oikonomidou, P. R., Sinha, S., Zhang, J., Lo Presti, V., Hamilton, C. R., . . . Rivella, S. (2019). Lack of Gdf11 does not improve anemia or prevent the activity of RAP-536 in a mouse model of β-thalassemia. Blood. 134(6):568-572. doi:10.1182/blood.2019001057. PMID: 31151988

2018

Guerra A., Musallam KM, Taher AT, Rivella S. (2018). Emerging Therapies. Hematol Oncol Clin North Am. 32(2):343-352. doi:10.1016/j.hoc.2017.11.002. PMID: 29458736

2013

Komaromy, A.M., Rowlan, J.S., Corr, A.T., Reinstein, S.L., Boye, S.L., Cooper, A.E., Gonzalez, A., . . . Aguirre, G.D. (2013). Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia. Mol Ther. 21(6),1131-1141. doi:10.1038/mt.2013.50. PMID: 23568263

Posters and Presentations

2022

Guerra, A. American Society of Hematology, New Orleans, LA. Title: Combination of a TGF-β ligand trap (RAP-GRL) and TMPRSS6-ASO is superior for correcting β-thalassemia. 2022.

Guerra, A. American Society of Hematology, New Orleans, LA. TNFα and Anti-IFNγ Rescues Chronic Anemia of Inflammation Phenotype in TNFαKO Mice Treated with Heat- Killed Brucella Abortus. 2022.

Guerra, A. American Society of Hematology, New Orleans, LA. Differential Effects of Monoferric Forms of Transferrin on Mouse Models of Anemia of Inflammation and Congenital Anemia. 2022.

Guerra, A. European Iron Club, University of Oxford, Oxford, United Kingdom. Title: Monoferric transferrin mutant mice show distinct inflammatory phenotypes in a mouse model of anemia of inflammation. 2022.

Guerra, A. European Iron Club, University of Oxford, Oxford, United Kingdom. Title: TNFα and Anti-IFNy rescues chronic anemia of inflammation phenotype in TNFαKO mice treated with heat-killed Brucella Abortus. 2022.

Guerra, A. European Iron Club, University of Oxford, Oxford, United Kingdom. Title: Combination of a TGF-β ligand trap (RAP-GRL) and TMPRSS6-ASO is superior for correcting β- thalassemia. (Plenary). 2022.

Guerra, A. European Iron Club, University of Oxford, Oxford, United Kingdom. Title: Discordant effects of monoferric transferrin forms on erythropoiesis in b-thalassemia intermedia mice. 2022.

Guerra, A. Federation of American Societies for Experimental Biology, Asheville, NC. Title: Obligate N-terminal but not C-terminal monoferric transferrin ameliorates anemia in b-thalassemic mice. 2022.

Guerra, A. Emerging Innovators Award, Children’s Hospital of Philadelphia, Philadelphia, PA. Title: Monoferric forms of transferrin serve as distinct signaling molecules in the modulation of erythropoietin sensitivity and ineffective erythropoiesis. 2022.

Guerra, A. Cooley's Anemia Symposium, New York, NY. Title: Combination of a TGF-β ligand trap (RAP-GRL) and TMPRSS6-ASO is superior for correcting β-thalassemia. 2022.

Guerra, A. Cooley's Anemia Symposium, New York, NY. Title: Differential effects of monoferric forms of transferrin on mouse models of anemia of inflammation and congenital anemia. 2022.

Guerra, A. European Hematology Association, Vienna, Austria. An activin receptor IIB ligand trap, in combination with TMPRSS6-ASO induced iron-restriction, is a superior treatment for correcting β-thalassemia in mice. 2022.

2021

Guerra, A. East-to-West Iron Club, Virtual Conference. Title: Combination of a Luspatercept-like drug (RAP-GRL) and TMPRSS6-ASO is superior to either drug alone for correcting β- thalassemia. 2021.

Guerra, A. CHOP Cell Biology Research Affinity Group Seminar, Children’s Hospital of Philadelphia, PA. Title: TNFα: controlling the delicate balance between infection, immunity, erythropoiesis, and self-preservation. 2021.

Guerra, A. American Society of Hematology, Atlanta, GA. TNFα controls the delicate balance between erythropoiesis and stem cell exhaustion during inflammatory stress. 2021.

Guerra, A. American Society of Hematology, Atlanta, GA. Combination of a Luspatercept-like drug (RAP-GRL) and TMPRSS6-ASO is superior to either drug alone for correcting β- thalassemia. 2021.

Guerra, A. American Society of Hematology, Atlanta, GA. Obligate N-terminal but not Cterminal monoferric transferrin ameliorates anemia in β-thalassemic mice. 2021.

Guerra, A. European School of Hematology: 2nd Translational Research Conference Erythropoiesis Control and Ineffective Erythropoiesis from Bench to Bedside, Virtual. Discordant effects of monoferric forms of transferrin on parameters of erythropoiesis in a murine model of β-thalassemia intermedia. 2021.

2020

Guerra, A. Hematology Seminar, Children’s Hospital of Philadelphia, Philadelphia, PA. Title: A tale of two lobes: N-terminal monoferric transferrin ameliorates ineffective erythropoiesis in a murine model of ß-thalassemia Intermedia, while C-terminal monoferric transferrin does not. 2020.

Guerra, A. Red Cell Club Meeting, Virtual Conference. Title: Discordant effects of monoferric forms of transferrin on parameters of erythropoiesis in a murine model of ßthalassemia Intermedia. 2020.

Guerra, A. East-to-West Iron Club, Virtual Conference. Title: Effects of monoferric forms of transferrin on parameters of erythropoiesis in a murine model of ß-thalassemia intermedia. 2020.

Awards and Honors

2022, ASH Abstract Achievement Award, American Society of Hematology
2020-2023, NIH Loan Repayment Program Renewal, Children’s Hospital of Philadelphia
2022, Emerging Innovators in Collaborative Science Award, Children’s Hospital of Philadelphia
2021, ASH Abstract Achievement Award, American Society of Hematology
2021, East-to-West Iron Club Trainee Award, East-to-West Iron Club Meeting
2021, Distinguished Post-doctoral Trainee Award, Children’s Hospital of Philadelphia
2020-2022, NIH NIDDK Diversity Supplement, Children’s Hospital of Philadelphia
2020, Featured Research Trainee of the Month (October), Children’s Hospital of Philadelphia
2018-2019, NIH Loan Repayment Program, Children’s Hospital of Philadelphia
2016-2019, NIH T32 Post-Doctoral Training Fellowship, University of Pennsylvania
2017, Distinguished Alumni Award, Achieving Independence Center, Temple University
2007-2010, NSF Bridge to the Doctorate Training Fellowship, Temple University

Leadership and Memberships

Memberships in Professional Organizations

2018-present, American Society of Hematology
2018-present, East-to-West Iron Club
2017-present, International BioIron Society