MD - University of Michigan Medical School, Ann Arbor, MI
Pediatrics - University of Colorado Health Sciences Center/The Children’s Hospital, Denver, CO
Pediatrics - University of Colorado Health Sciences Center/The Children’s Hospital, Denver, CO
Pediatric Nephrology - University of Virginia Medical Center, Charlottesville, VA
Pediatric Nephrology - University of Colorado Health Sciences Center/The Children’s Hospital, Denver, CO
Pediatric Nephrology – American Board of PediatricsPediatrics – American Board of Pediatrics
Attending Physician
Professor, Perelman School of Medicine at the University of Pennsylvania
Klawitter J, Jackson MJ, Smith PH, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Christians U, Klawitter J. Kynurenines in polycystic kidney disease. J Nephrol 2023; 36(1):83-91.
Mekahli D, Guay-Woodford L, Cadnapaphornchai MA, Greenbaum L, Mieczyslaw L, Seeman T, Dandurand A, Shi L, Sikes K, Shoaf S, Schaefer F. Tolvaptan for children and adolescents with autosomal dominant polycystic kidney disease: Randomized controlled trial. Clin J Am Soc Nephrol 2023; 18(1):36-46.
Mekahli D, Liebau MC, Cadnapaphornchai MA, Goldstein SL, Greenbaum LA, Litwin M, Seeman T, Schaefer F, Guay-Woodford LM. Design of two ongoing clinical trials of tolvaptan in the treatment of pediatric patients with autosomal recessive polycystic kidney disease. BMC Nephrol 2023;24(1):33. Doi:10.1186/s12882-023-03072-x.
Cadnapaphornchai MA, Ong ACM. Hypertension in young adults with autosomal dominant polycystic kidney disease: a case for early screening? Clin Kidney J 2023; 16(6):901-904.
Yang X, Wang W, Gitomer B, Cadnapaphornchai MA, Xing F, Chonchol M. Imaging biomarkers in young patients with ADPKD. Kidney Int Rep 2023;8(10):2153-2155.
Nowak KL, Farmer-Bailey H, Wang W, You Z, Steele C, Cadnapaphornchai MA, Klawitter J, Patel N, George D, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin therapy to treat vascular dysfunction in children and young adults with ADPKD: A randomized clinical trial. Clin J Am Soc Nephrol 2022; 17(2):240-250.
Baliga MM, Klawitter J, Christians U, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Klawitter J. Metabolic profiling in children and youth with autosomal dominant polycystic kidney disease. Sci Rep 2021;11(1):6629
Nowak KL, Farmer-Bailey H, Cadnapaphornchai MA, You Z, George D, Wang W, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin therapy to treat vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease: Design and baseline characteristics of participants. Contemp Clin Trials Commun 2020;19:100635.
Schaefer F, Mekahli D, Emma F, Gilbert RD, Bockenhauer D, Cadnapaphornchai MA, Shi L, Dandurand A, Sikes K, Shoaf SE. Tolvaptan use in children and adolescents with autosomal dominant polycystic kidney disease: Rationale and design of a two-part, randomized, double-blind, placebo-controlled trial. Eur J Pediatr 2019;178(7):1013-1021.
Gimpel C, Bergmann C, Bockenhauer D, Breysem L, Cadnapaphornchai MA, Cetiner M, Dudley J, Emma F, Konrad M, Harris T, Harris PC, König J, Liebau MC, Marlais M, Mekahli D, Metcalfe AM, Oh J, Perrone RD, Sinha MD, Titieni A, Torra R, Weber S, Winyard PJD, Schaefer F. International Consensus Statement on the Diagnosis and Management of Autosomal Dominant Polycystic Kidney Disease in Children and Young People. Nat Rev Nephrol 2019;15(11):713-726.
Nowak KL, Farmer H, Cadnapaphornchai MA, Gitomer B, Chonchol M. Vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease. Nephrol Dial Transplant 2017;32:342-7
Stewart CL, Acker SN, Pyle LL, Kulungowski A, Cadnapaphornchai M, Bruny JL, Karrer F. Factors associated with peritoneal dialysis catheter complications in children. J Pediatr Surg 51:159-62, 2016.
Nowak KL, Cadnapaphornchai MA, Chonchol MB, Schrier RW, Gitomer G. Long-term outcomes in patients with very early onset autosomal dominant polycystic kidney disease. Am J Nephrol 2016;44:171-8.
Wang W, You Z, Cadnapaphornchai M, Chonchol M, Gitomer B. Angiogenic factors predict progression in young patients with autosomal dominant polycystic kidney disease. EC Paediatrics 2.4(2016):205-14.
Rao S, Abzug MJ, Carosone-Link P, Peterson T, Child J, Siparksy G, Soranno D, Cadnapaphornchai MA, Simoes EA. Intravenous acyclovir and renal dysfunction in children: a matched case control study. J Pediatr 166:1462-8, 2015.
Klawitter J, McFann K, Pennington AT, Wang W, Klawitter J, Christians U, Schrier RW, Gitomer B, Cadnapaphornchai MA. Pravastatin therapy and biomarker changes in children and young adults with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 10:1534-41, 2015.
Faubel S, Patel NU, Lockhart ME, Cadnapaphornchai MA. Renal relevant radiology: Use of ultrasonography in patients with AKI. Clin J Am Soc Nephrol 9:382-94, 2014.
Klawitter J, Klawitter J, McFann K, Pennington AT, Abebe KZ, Brosnahan G, Cadnapaphornchai MA, Chonchol M, Gitomer B, Christians U, Schrier RW. Bioactive lipid mediators in polycystic kidney disease. J Lipid Res 55:1139-49, 2014.
Cadnapaphornchai MA, George D, Wang W, Reed-Gitomer B, McFann K, Strain JD, Schrier RW. Effect of pravastatin on total kidney volume, left ventricular mass index, and microalbuminuria in pediatric autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 9:889-96, 2014.
Guay-Woodford LM, Bissler JJ, Braun MC, Bockenhauer D, Cadnapaphornchai MA, Dell KM, Kerecuk L, Liebau MC, Alonso-Peclet MH, Shneider B, Emre S, Heller T, Kamath BM, Murray KF, Moise K, Eichenwald EE, Evans J, Keller RL, Wilkins-Haug L, Bergmann C, Gunay-Aygun M, Hooper SR, Hardy KK, Hartung EA, Streisand R, Perrone R, Moxey-Mims M. Consensus expert recommendations for the diagnosis and management of autosomal recessive polycystic kidney disease: Report of an international conference. J Pediatr 165:611-7, 2014.
Schrier RW, Brosnahan G, Cadnapaphornchai MA, Chonchol M, Friend K, Gitomer B, Rossetti S. Predictors of autosomal dominant polycystic kidney disease progression. J Am Soc Nephrol 25:2399-418, 2014.
Klawitter J, Reed-Gitomer BY, McFann K, Pennington AT, Klawitter J, Abebe KZ, Klepacki J, Cadnapaphornchai MA, Brosnahan G, Chonchol MB, Christians U, Schrier RW. Endothelial dysfunction and oxidative stress in polycystic kidney disease. Am J Physiol Renal Physiol 307:F1198-206, 2014.
Cheung CC, Cadnapaphornchai MA, Ranadive SA, Gitelman SE, Rosenthal SM. Persistent elevation of urine aquaporin-2 during water loading in a child with nephrogenic syndrome of inappropriate antidiuresis (NSIAD) caused by a R137L mutation in the V2 vasopressin receptor. Int J Pediatr Endocrinol 2012 Feb 10; 2012:3.
Seltz LB, Bakel LA, Tiehen J, Gao D, Cadnapaphornchai MA, Lum G, Ford D. Efficacy and safety of clopidogrel in children with diarrhea-associated hemolytic uremic syndrome. Thromb Res 130:e26-30, 2012.
Reed BY, Masoumi A, Elhassan E, McFann K, Cadnapaphornchai MA, Maahs DM, Snell-Bergeon JK, Schrier RW. Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease. Kidney Int 79:128-34, 2011.
Cadnapaphornchai MA, Masoumi A, McFann K, Strain JD, Schrier RW. Magnetic resonance imaging for assessment of kidney and cyst volume in children with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 6:369-76, 2011.
Cadnapaphornchai MA, George DM, Masoumi A, McFann K, Strain JD, Schrier RW. Effect of statin therapy on disease progression in pediatric ADPKD: Design and baseline characteristics of participants. Contemp Clin Trials 32:437-45, 2011.
Helal I, Reed B, McFann K, Yan XD, Fick-Brosnahan GM, Cadnapaphornchai M, Schrier RW. Glomerular hyperfiltration in children with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 6:2439-43, 2011.
Grantham JJ, Cook LT, Wetzel LH, Cadnapaphornchai MA, Bae KT. Evidence of extraordinary growth in the progressive enlargement of renal cysts. Clin J Am Soc Nephrol 5:889-896, 2010.
Reed B, Nobakht E, Dadgar S, Bekheirnia MR, Masoumi A, Belibi F, Yan XD, Cadnapaphornchai MA, Schrier RW. Renal ultrasonographic evaluation in children at risk for autosomal dominant polycystic kidney disease. Am J Kidney Dis 56:50-56, 2010.
Dennen P, Altmann C, Kaufman J, Klein C, Andres-Hernando A, Ahuja N, Edelstein CL, Cadnapaphornchai MA, Keniston A, Faubel S. Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery. Crit Care 14:R181, 2010.
Schweiger B, Moriarty MW, Cadnapaphornchai MA. Case report: severe neonatal hyperkalemia due to pseudohypoaldosteronism type 1. Curr Opin Pediatr 21:269-271, 2009.
Cadnapaphornchai MA, McFann K, Strain JD, Masoumi AM, Schrier RW. Prospective change in renal volume and function in children with ADPKD. Clin J Am Soc Nephrol 4:820-829, 2009.
Cadnapaphornchai MA, McFann K, Strain JD, Masoumi AM, Schrier RW. Evidence of increased left ventricular mass index (LVMI) in ADPKD children with borderline hypertension. Kidney Int 74:1192-1196, 2008.
Friedman K, Wallis T, Maloney K, Mengshol S, Hendrickson R, Cadnapaphornchai MA. An unusual cause of pediatric hypertension. J Pediatr 151:206-212, 2007.
Wang W, Li C, Summer SN, Falk S, Cadnapaphornchai MA, Chen YC, Schrier RW. Molecular analysis of impaired urinary diluting capacity in glucocorticoid deficiency. Am J Physiol Renal Physiol 290:F1135-F1142, 2006.
Li C, Wang W, Summer SN, Cadnapaphornchai MA, Falk S, Umenishi F, Schrier RW. Hyperosmolality in vivo upregulates aquaporin-2 water channel and Na-K-2Cl cotransporter in Brattleboro rats. J Am Soc Nephrol 17:1657-1664, 2006.
Cadnapaphornchai MA, Fick-Brosnahan GM, Duley I, Johnson AM, Strain JD, DeGroff CG, Schrier RW. Design and baseline characteristics of participants in the study of antihypertensive therapy in children and adolescents with autosomal dominant polycystic kidney disease (ADPKD). Contemp Clin Trials 26:211-222, 2005.
Chen YC, Cadnapaphornchai MA, Yang J, Summer SN, Falk S, Li C, Wang W, Schrier RW. Nonosmotic release of vasopressin and renal aquaporins in impaired urinary dilution in hypothyroidism. Am J Physiol Renal Physiol 289:F672-678, 2005.
Shamshirsaz AA, Bekheirnia MR, Kamgar M, Johnson AM, McFann K, Cadnapaphornchai M, Haghighi NN, Schrier RW. Autosomal-dominant polycystic kidney disease in infancy and childhood: progression and outcome. Kidney Int 68:2218-2224, 2005.
Chen YC, Cadnapaphornchai MA, Summer SN, Falk S, Schrier RW. Molecular mechanisms of impaired urinary concentrating ability in glucocorticoid-deficient rats. J Am Soc Nephrol 16:2864-2871, 2005.
Cadnapaphornchai MA, Rogachev B, Summer SN, Chen YC, Gera L, Stewart JM, Schrier RW. Evidence for bradykinin as a stimulator of thirst. Am J Physiol Renal Physiol 286:F875-F880, 2004.
Cadnapaphornchai MA, Kim YW, Gurevich AK, Summer SN, Thurman JM, Schrier RW. Urinary concentrating defect in hypothyroid rats: role of sodium, potassium, 2-chloride co-transporter, and aquaporins. J Am Soc Nephrol 14:566-574, 2003.
Cadnapaphornchai MA, Summer SN, Falk S, Thurman JM, Knepper MA, Schrier RW. Effect of primary polydipsia on aquaporin and sodium transporter abundance. Am J Physiol Renal Physiol 285:F965-F971, 2003.
Umenishi F, Cadnapaphornchai MA, Summer SN, Schrier RW. Aquaporin 2 excretion in the urine: comparison of ELISA, radioimmunoassay, and quantitative immunoblot analysis. Kidney Int 62:2288-2293, 2002.
Ohara M, Cadnapaphornchai MA, Summer SN, Falk S, Yang J, Togawa T, Schrier RW. Effect of mineralocorticoid deficiency on ion and urea transporters and aquaporin water channels in the rat. Biochem Biophys Res Commun 299:285-290, 2002.
Cadnapaphornchai MA, Ohara M, Knotek M, Rogachev B, Ladtkow T, Carter EP, Schrier RW. Chronic NOS inhibition reverses systemic vasodilation and glomerular hyperfiltration in pregnancy. Am J Physiol Renal Physiol 280:F592-F598, 2001.
Cadnapaphornchai M, Norwood VF, Saulsbury FT. Hypocomplementemic urticarial vasculitis: a pediatric case report. Pediatr Nephrol 14:328-331, 2000.
Cadnapaphornchai MA, Ford DM, Tyson RW, Lum GM. Cystic renal lymphangiectasia presenting as renal insufficiency in childhood. Pediatr Nephrol 15:129-131, 2000.
Xu L, Carter EP, Ohara M, Martin PY, Rogachev B, Morris K, Cadnapaphornchai MA, Knotek M, Schrier RW. Neuronal nitric oxide synthase and systemic vasodilation in rats with cirrhosis. Am J Physiol Renal Physiol 279:F1110-F1115, 2000.
Sondheimer JM, Asturias E, Cadnapaphornchai M. Infection and cholestasis in neonates with intestinal resection and long-term parenteral nutrition. J Pediatr Gastr Nutr 27:131-137, 1998.
Sondheimer JM, Cadnapaphornchai M, Sontag M, Zerbe GO. Predicting the duration of dependence on parenteral nutrition after neonatal intestinal resection. J Pediatr 132:80-84, 1998.
Cadnapaphornchai M, Faix RG. Increased nosocomial infection in neutropenic low birth weight (2000 grams or less) infants of hypertensive mothers. J Pediatr 121:956-961, 1992.
Mekahli D, Guay-Woodford LM, Cadnapaphornchai MA, Greenbaum LA, Litwin M, Seeman T, Dandurand A, Zhang Z, Sikes K, Shoaf SE, Schaefer F. Phase 3 trial of tolvaptan in pediatric autosomal dominant polycystic kidney disease (ADPKD): Two years of data from an open-label extension. Poster presentation, ERA-EDTA 60th Congress, Milan, Italy, June 2023.
Mekahli D, Guay-Woodford LM, Cadnapaphornchai MA, Greenbaum LA, Litwin M, Seeman T, Dandurand A, Zhang Z, Sikes K, Shoaf SE, Schaefer F. Phase 3 trial of tolvaptan in pediatric autosomal dominant polycystic kidney disease (ADPKD): Two years of data from an open-label extension. Poster presentation, European Society for Pediatric Nephrology 55th Annual Meeting, Vilnius, Lithuania, September 2023.
Nowak KL, Farmer-Bailey H, Wang W, You Z, Steele C, Cadnapaphornchai MA, Klawitter J, Patel N, George D, Jovanovich A, Soranno D, Gitomer BY, Chonchol M. Curcumin therapy to treat vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease (ADPKD). American Society of Nephrology Annual Meeting, 2021.
Cadnapaphornchai MA, Mekahli D. “Autosomal dominant polycystic kidney diseases” in Pediatric Nephrology, Francesco Emma, Stuart Goldstein, Arvind Bagga, Carlton Bates, Rukshana Shroff, editors, 2021.
Cadnapaphornchai MA, Soranno DE, Kirkley M, Bisio T, Woloschuk R. “Neonatal nephrology” in Merenstein & Gardner’s Handbook of Neonatal Intensive Care, Ninth edition, Sandra Lee Gardner, Brian Carter, Mary I. Enzman-Hines, Susan Niermeyer, editors, 2020.
Cadnapaphornchai MA, Lum GM. “Kidney & urinary tract” in Current Diagnosis & Treatment—Pediatrics, 24rd edition, William Hay, Myron Levin, Robin Deterding, Mark Abzug, editors, 2018.
Cadnapaphornchai MA, Lum GM. “Kidney & urinary tract” in Current Diagnosis & Treatment—Pediatrics, 23rd edition, William Hay, Myron Levin, Robin Deterding, Mark Abzug, editors, 2016.
Cadnapaphornchai MA. “Water homeostasis” in Clinical Pediatric Nephrology, Third edition, Kanwal Kher, H. William Schnaper, Sudesh Paul Makker, editors. 2016. https://www.crcpress.com/Clinical-Pediatric-Nephrology-Third-Edition/Khe...
Cadnapaphornchai MA, Hernandez JA, Soranno DE, Schoenbein M, Woloschuk R. “Neonatal nephrology” in Merenstein & Gardner’s Handbook of Neonatal Intensive Care, Eighth edition, Sandra Lee Gardner, Brian Carter, Mary I. Enzman-Hines, Jacinto A. Hernandez, editors, 2015
Cadnapaphornchai P, Cadnapaphornchai MA. “Nephrolithiasis” in Calcium and Phosphate Metabolism in Chronic Renal Diseases, First edition, Chen-Hsing Hsu, editor. 2006.
Cadnapaphornchai MA, Chantler C. “Pediatric Nephrology” in Diseases of the Kidney and Urinary Tract, Eighth edition, Robert W. Schrier, editor. 2006.
Cadnapaphornchai MA, Briner VA, Schrier RW. “Renal function in pregnancy” in Fluid and Electrolyte Disorders, Sixth edition, Robert W. Schrier, editor. 2002.
Abraham WT, Cadnapaphornchai MA, Schrier RW. “Cardiac failure, liver disease, and nephrotic syndrome” in Diseases of the Kidney and the Urinary Tract, Seventh edition, Robert W. Schrier, editor. 2001.
Cadnapaphornchai MA, Briner VA, Schrier RW. “Hypertension and pregnancy” in Diseases of the Kidney and Urinary Tract, Seventh edition, Robert W. Schrier, editor. 2001.
Cadnapaphornchai M. Current Management and Future Directions in ADPKD. Nephrology Conference. Medical College of Wisconsin, Milwaukee, WI, May 2023.
Cadnapaphornchai M. Update on ADPKD. Nephrology noon conference. University of Indiana School of Medicine, Indianapolis, IN, December 2022.
Cadnapaphornchai M. Lunch & Learn: Chronic kidney disease, September 2021, to local provider community via Webex Nephrolithiasis, October 2021, in-person educational session for community providers.
2007, Thai Physicians Foundation Medical Research Award
2006, Press Ganey Survey Practice Plan Award
American Journal of Physiology Renal Physiology
Kidney International
Nephrology, Dialysis, & Transplantation
Critical Care Medicine
Journal of the American Society of Nephrology
Journal of Pediatrics
Clinical Journal of the American Society of Nephrology
Acta Paediatrica
Critical Care Medicine
Pediatric Nephrology
Frontiers in Pediatrics
2020-present, International Pediatric Nephrology Association
2004-present, American Society of Nephrology
- 2005-present, Fellow
1997-present, American Society of Pediatric Nephrology