An interprofessional team at Children’s Hospital of Philadelphia is transforming CHOP’s approach to fetal medicine through a first-of-its-kind data integration platform. The Clinical Outcomes Data Archive (CODA) platform offers clinicians real-time data to help inform earlier interventions and treatment strategies in CHOP’s Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment (CFDT). A paper outlining CODA’s benefits, applications and potential broader impact was recently published in the journal Fetal Diagnosis and Therapy.

CHOP is on the forefront of investigating the design and delivery of gene therapies to curb and potentially cure congenital diseases.

CHOP’s “Advancing Craniofacial Treatment with Genomics and Gene Therapy” Frontier Program is poised to harness genomic technologies to spearhead innovations in gene therapy, improve diagnostics, predict treatment outcomes and develop new therapies for children.

Our innovative fetal patient registry and data management system has made remarkable strides impacting both clinical care and research.

Expanded criteria for FETO procedure and transition to exclusively using muscle flap repair.

In its first year, our Newborn/Infant Intensive Care Unit at CHOP’s Middleman Family Pavilion in King of Prussia had over 250 admissions and expanded from 10 beds to 18.

An experimental gene therapy, studied in a preclinical model of Batten disease, was found to slow symptoms and extend lifespan

Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania unlocked important new insights in how the immune system selects the right signals to alert T cells, a vital step in the prevention and treatment of serious illness. The findings were published in the journal Proceedings of the National Academy of Sciences (PNAS).

A report estimates that vaccines were directly responsible for a 40% decrease in infant deaths over the last 50 years. Find out more. You'll also learn about the rates of long COVID and about antibiotic-resistant bacteria in Ukraine.

Watch as Dr. Handy discusses which adults might benefit from an additional dose of polio vaccine.